多西环素联合维胺酯治疗痤疮疗效观察

目的:观察口服维胺酯胶囊和多西环素治疗寻常痤疮的临床疗效。方法:将100例寻常痤疮患者随机分成两组:治疗组:口服维胺酯胶囊和多西环素;对照组:单纯口服多西环素。疗程均为6周。结果:治疗组总有效率86,%对照组46%。两组统计学处理有显著性差异(P<0.01),尤其重度痤疮治疗组临床效果明显优于对照组。结论:口服维胺酯胶囊与多西环素联合治疗痤疮有良好的治疗效果。     

强脉冲光与中药联合治疗面部寻常性痤疮的疗效观察

目的:探讨强脉冲光与中药联合治疗颜面部寻常性痤疮的疗效。方法:选取来笔者科室就诊的颜面部寻常性痤疮患者115例,随机分为试验组及对照组。试验组:采用常规中药,同时配合强脉冲光治疗;对照组:单纯采用中药治疗。两组均外用莫匹罗星软膏,治疗间隔3周,连续治疗4次为1个疗程,疗程结束后评价疗效。结果:1个疗程后评价疗效,试验组有效率90.5%,对照组有效率61.6%,两组疗效比较,差异具有统计学意义(P0.05)。结论:强脉冲光与中药联合治疗颜面部寻常性痤疮,比常规服用中药治疗痤疮效果显著,可临床推广应用。     

丹参酮胶囊内服联合红蓝光治疗寻常性痤疮疗效分析

目的:观察丹参酮胶囊内服联合红蓝光治疗寻常性痤疮的疗效。方法:选择来笔者科室就诊的126例寻常性痤疮患者,随机分为两组。治疗组:64例,采用丹参酮胶囊内服联合红蓝光照射。丹参酮胶囊,3次/d,1g/次,6周为1个疗程。红蓝光照射,前2周蓝光治疗,后2周红光治疗,2次/周,每次15min,61J/cm2,疗程4周,共治疗8次;对照组:62例,仅做红蓝光照射,方法同治疗组。随访2个月判定疗效。结果:治疗组总有效率为73.4%,对照组组总有效率为43.5%,两组疗效比较有统计学差异(P0.05)。结论:丹参酮胶囊内服联合红蓝光治疗寻常性痤疮疗效显著,协同作用明显,值得临床推广。     

超脉冲二氧化碳激光联合强脉冲光治疗面部寻常性痤疮临床分析

目的:通过对比超脉冲二氧化碳激光联合强脉冲光治疗与两种方法分别治疗寻常性痤疮的疗效,探究综合治疗的新思路。方法:将126例门诊患者随机分成三组,分别给予强脉冲光、超脉冲二氧化碳激光、超脉冲二氧化碳激光联合强脉冲光交替治疗,治疗4次,12周为1个疗程,1个疗程后统计各组疗效并分析。结果:联合治疗组与单一治疗组比较,疗效显著(P0.05);单一治疗组间无显著性差异(P0.05)。结论:超脉冲二氧化碳激光与强脉冲光联合治疗寻常性痤疮的疗效优于单一方法治疗,但两种单一治疗方法间的优劣并未显现。     

540nm强脉冲光联合清热散结胶囊治疗痤疮红斑疗效观察

目的：观察540nm强脉冲光联合清热散结胶囊治疗痤疮红斑的疗效。方法：将90例痤疮红斑患者随机分为治疗组和对照组,两组各45例,均采用540nm强脉冲光治疗,能量15～18J/cm2,脉宽12～15ms,每4周1次,3次为1个疗程。治疗组同时给予口服清热散结胶囊1.65g,3次/d,用药8周。两组均在末次治疗后12周判定疗效。结果：治疗组和对照组的有效率分别为82.22%和64.44%,治疗组疗效优于对照组（P＜0.05）,两组均无明显不良反应。结论：540nm强脉冲光联合清热散结胶囊治疗痤疮红斑安全、有效。     

美他环素联合0.025%维A酸乳膏治疗寻常性痤疮疗效观察

目的：评价美他环素联合0.025%维A酸乳膏治疗中度寻常性痤疮的疗效与安全性。方法：将116例寻常性痤疮患者随机分为治疗组和对照组,治疗组59例,口服美他环素胶囊0.3g,2次/天;对照组57例,口服甲硝唑片0.2g,3次/天;两组均于睡前外用0.025%维A酸乳膏,每天1次,疗程4周。结果：治疗组痊愈率为62.7%,有效率94.9%;对照组分别为28.1%,71.9%;两组痊愈率和有效率比较差异均有统计学意义（χ2=2.48,2.77,P〈0.01）。结论：美他环素联合0.025%维A酸乳膏治疗中度寻常性痤疮疗效确切,安全性高。     

强脉冲光联合医学护肤品治疗面部寻常型痤疮临床观察

目的：观察强脉冲光联合含木瓜蛋白酶及马齿苋医学护肤品治疗面部寻常型痤疮的临床疗效。方法：将68例面部寻常型痤疮患者随机分为两组：治疗组41例,强脉冲光联合含木瓜蛋白酶及马齿苋医学护扶品治疗;对照组27例,单纯强脉冲光治疗。结果：两组患者面部炎性皮损经治疗后,治疗组有效率95.1%、对照组70.4%,χ2=6.10,P〈0.05,差异有统计学意义。治疗组患者皮肤整体平整性的改善明显优于对照组。结论：采用强脉冲光联合含木瓜蛋白酶及马齿苋的医学护肤品治疗面部寻常型痤疮,在运用强脉冲光有效治疗痤疮的同时使用医学护肤品既可以修复强脉冲光治疗后皮肤功能屏障的损伤,还能辅助治疗面部寻常型痤疮皮损,无严重不良反应,值得临床推广应用。     

1450nm半导体激光联合强脉冲光治疗中度寻常性痤疮的临床观察

目的:观察1 450nm半导体激光联合强脉冲光治疗中度寻常性痤疮的疗效及安全性。方法:选取中度寻常性痤疮患者160例,按照就诊顺序随机分为试验组与对照组,试验组:80例,采用1 450nm半导体激光联合强脉冲光治疗;对照组:80例,使用1 450nm半导体激光治疗。治疗4次后评估两组的疗效,并评估两组患者的满意度。结果:试验组与对照组治疗4次后有效率分别为95.00%和82.50%;试验组和对照组满意度分别为82.50%和68.75%,试验组有效率比对照组好,满意度试验组比对照组高,两组比较差异有统计学意义(P<0.05)。结论:1 450nm半导体激光联合强脉冲光治疗中度痤疮短期疗效好,患者满意度高,不良反应少,并且长期疗效理想,可供临床选用。     

新型强脉冲光治疗寻常性痤疮临床观察

目的:观察应用新型强脉冲光治疗寻常性痤疮的疗效和安全性。方法:采用以色列Active OpticalSystems强脉冲光治疗系统(GEM专利技术的光子嫩肤仪)治疗50例寻常性痤疮患者1个疗程,观察和记录临床疗效及不良反应。结果:50例患者,基本痊愈12例(24%),显效28例(56%),总有效率80%。治疗后无皮肤红肿,色素沉着等不良反应。结论:新型强脉冲光治疗寻常性痤疮疗效显著,安全性高。     

维胺酯胶囊联合局部封闭治疗聚合性痤疮疗效观察

目的：观察维胺酯胶囊联合局部封闭治疗聚合性痤疮的有效性及安全性。方法：选取74例重度痤疮患者,随机分为治疗组（38例）和对照组（36例）,治疗组采用口服维胺酯胶囊联合局部封闭治疗,对照组仅口服维胺酯胶囊治疗。两组均外用氯霉素水杨酸酊,8周后观察疗效并做比较。结果：治疗组有效率86．84％,对照组有效率66．66％,疗效比较差异有统计学意义（X^2=4．252,P〈0．05）。结论：维胺酯胶囊联合局部封闭治疗聚合性痤疮疗效满意,见效快,不良反应小。     

三种硫磺洗剂治疗Ⅱ度寻常性痤疮疗效观察

目的：观察10%磺胺醋酰钠硫磺洗剂、1%氯霉素硫磺洗剂、5%硫磺洗剂外用治疗Ⅱ度寻常性痤疮的疗效。方法：采取随机对照双盲的方法分组,A组：10%磺胺醋酰钠硫磺洗剂治疗,93例;B组：1%氯霉素硫磺洗剂治疗,89例;C治疗：5%硫磺洗剂治疗,84例。疗程均为8周。结果：A组显效率67.7%,总有效率92.5%;B组显效率47.2%,总有效率79.8%;C组显效率16.7%,总有效率60.7%。A和B组显效率比较具有显著性差异（P〈0.05）,B和C组显效率比较具有显著性差异（P〈0.05）;A和B组的总有效率比较具有显著性差异（P〈0.05）,B和C组的总有效率比较具有显著性差异（P〈0.05）。结论：10%磺胺醋酰钠硫磺洗剂治疗Ⅱ度寻常性痤疮疗效优于1%氯霉素硫磺洗剂,1%氯霉素硫磺洗剂则优于5%硫磺洗剂。     

三种光疗法治疗寻常性痤疮疗效观察

目的：评价光动力学疗法（PDT）,强脉冲光（IPL）和红蓝光（LED）治疗中、重度寻常性痤疮的疗效。方法：将90例中、重度痤疮患者随机分为三组：PDT治疗组,IPL治疗组和LED红蓝光治疗组。分别于治疗前、治疗中期（治疗1个月）和末次治疗结束后评价疗效。结果：治疗中期评价时,PDT、IPL、LED治疗组总有效率分别为93.3%、60.0%和36.7%,平均皮损减少率分别为90.4%、69.0%和39.8%。要达到炎症性皮损痊愈,PDT组平均需要（3±1.52）个治疗周期,IPL组（6±2.15）个治疗周期,LED组（9±3.34）个治疗周期。结论：光疗法治疗中、重度痤疮疗效显著,PDT组疗法效果优于IPL和LED组,副作用少,有很好应用前景,而长期疗效有待进一步观察。     

两种波长强脉冲光“4＋3”联合治疗痤疮及痤疮后红斑的疗效

目的 评价两种波长强脉冲光（intensive pulsed light,IPL）以“4＋3”方式联合治疗面部痤疮和痤疮后红斑的疗效.方法 将80例面部痤疮患者分为治疗组和对照组,每组各40例.治疗组先单独采用420 nm波长IPL治疗4次,每次间隔1周;再采用420 nm和540 nm两种波长IPL联合治疗3次,每次间隔4周.对照组外用0.1％阿达帕林凝胶,每晚1次,共16周.结果 （1）4周炎性皮损治疗有效率：治疗组65.0％（26/40）,对照组47.5％（19/40）,两组差异有统计学意义（P＜0.05）;16周炎性皮损治疗有效率：治疗组85.0％（34/40）,对照组62.5％（25/40）,两组差异有统计学意义（P＜0.05）.（2）红斑治疗有效率：治疗组90.0％（36/40）,对照组37.5％（15/40）,两组差异有统计学意义（P＜0.01）.结论 采用“4＋3”方式联合使用420 nm和540 nm两种波长IPL治疗痤疮和痤疮后红斑安全、有效.     

红蓝光与强脉冲光治疗痤疮的临床疗效分析

目的:观察红蓝光与强脉冲光联合应用治疗痤疮的疗效。方法:150例痤疮患者,随机分为红蓝光组、强脉冲光组和联合治疗组并观察、评价疗效,且在治疗期间及治疗后3个月,随访并观察不良反应发生情况。结果:治疗5周后,联合治疗组患者GAGS评分和有效率高于其他两组,其差异无统计学意义(P<0.05)。在治疗全程及治疗后3个月内,联合治疗组患者不良反应发生率低于其他两组。结论:红蓝光与强脉冲光联合应用治疗痤疮,在保证治疗效果的同时,可以降低不良反应发生率,对痤疮治疗有重要意义。     

强脉冲光及微晶磨削治疗面部寻常性痤疮的疗效分析

目的:比较强脉冲光和微晶磨削治疗不同时期面部寻常性痤疮的临床疗效。方法:将90例痤疮患者随机分为两组:A组:48例,采用强脉冲光治疗;B组:42例,采用微晶磨削治疗。治疗时间各组分别为1个疗程,治疗后观察两组的临床疗效。结果:强脉冲光治疗针对轻中度痤疮效果明显,微晶磨削治疗针对重度尤其是脓疱性痤疮及其痤疮后留下的凹陷性瘢痕效果显著,差异有显著统计学意义。结论:不同时期的痤疮采用不同方法治疗可以取得较好的临床疗效。     

Effectiveness of Photodynamic Therapy with Topical 5-Aminolevulinic Acid and Intense Pulsed Light versus Intense Pulsed Light Alone in the Treatment of Acne Vulgaris: Comparative Study

Background. Photodynamic therapy (PDT) involves the activation of a photosensitizing agent by light to produce oxygen intermediates that destroy target tissues. Topical 5-aminolevulinic acid (ALA) is converted to protoporphyrin IX, a very potent photosensitizer, which accumulates in human skin, particularly in the epidermis and its appendages.
Objective. To study the effect of PDT in acne vulgaris using topical ALA and intense pulsed light (IPL).
Methods. Thirteen individuals with varying degrees of acne were treated after a 3-week washout period. Twenty percent ALA hydrochloride (DUSA Pharmaceuticals, Wilmington, MA, USA) was applied to half of the face, and after 3 hours, the whole face was exposed to intense pulsed light (Quantum SR, Lumenis, Santa Clara, CA, USA) using a 560 nm cutoff filter starting at a fluence of 26 J/cm. The procedure was done twice at 2-week intervals, and the patients were clinically evaluated on the second, fourth, and eighth weeks.
Results. All patients had no apparent improvement on the second week on both facial halves. In fact, some of the patients developed acute acneiform eruptions on the side treated with ALA. By the fourth week, however, most of the patients had visible improvement of facial acne that was more significant on the ALA-treated side of the face. This persisted until the eighth week post-treatment. On the other hand, the facial half treated with intense pulsed light only showed a return to baseline of their facial acne.
Conclusion. ALA-IPL are beneficial in the management of acne vulgaris and may be used in combination with other forms of acne treatment or may be an alternative treatment for patients who do not want to take systemic retinoids.     

强脉冲光结合氨基乙酰丙酸治疗痤疮的临床观察

目的：观察强脉冲光（intense pulsed light,IPL）结合氨基乙酰丙酸（aminolevulinic acid,ALA）～光动力疗法（photodynamic therapy,PDT）治疗炎症性痤疮的疗效及安全性。方法：选取10名中重度炎症性痤疮患者,左右侧面部随机分为治疗侧（IPL结合ALA—PDT治疗）及对照侧（单纯IPL治疗）,共治疗3次,治疗间隔时间4用。治疗结束后,由医生及受试者进行主观评价;应用非创伤性仪器检测皮肤亮度（1ightness,L值）、皮脂含量及角质层含水量。结果：治疗侧与对照侧皮损消退率分别为74．3％和49．6％,有效率80．0％和50．0％,满意率80％和30％。治疗侧L值显著升高（P〈0．05）,皮脂含量显著减少（P〈0．05）。两种治疗对角质层含水量均无显著影响。副作用包括短暂且可耐受的轻微红肿、发热或局部刺痛感。结论：IPL结合ALA—PDT治疗炎症性痤疮疗效好,副作用小。     

姜黄消痤搽剂联合痤疮涂膜剂治疗寻常性痤疮疗效观察

目的：评价姜黄消痤搽剂联合痤疮涂膜剂治疗寻常性痤疮的疗效与安全性。方法：将150例痤疮患者随机分为三组：试验组：白天外用姜黄消痤搽剂,2次/天,晚上睡前外用痤疮涂膜剂,1次/天;对照Ⅰ组：白天外用姜黄消痤搽剂,2次/天;对照Ⅱ组：晚上睡前外用痤疮涂膜剂,1次/天。在治疗前、治疗第4周、8周时及停止治疗后2个月观察疗效。结果：治疗8周后,姜黄消痤搽剂和痤疮涂膜剂试验组有效率（83.33%）与姜黄消痤搽剂组（61.22%）及痤疮涂膜剂组（64.58%）相比,差异有统计学意义（均P〈0.05）,且不良反应少。结论：姜黄消痤搽剂联合痤疮涂膜剂治疗寻常性痤疮安全,疗效满意。     

Intense pulsed light versus benzoyl peroxide 5 % gel in treatment of acne vulgaris

Acne is a common disorder affecting the pilosebaceous unit. Despite many advances in the treatments of acne vulgaris the best option is still controversial as the pathogenesis of acne is rather complex, necessitating various combination therapies. The objective of this study is to compare the clinical efficacy of intense pulsed light therapy (IPL) versus benzoyl peroxide 5 % for the treatment of inflammatory acne. Fifty patients of both sexes, (15 males and 35 females) aged (18–27 years), with mild-to-severe acne and Fitzpatrick skin phototype IV were enrolled in this study. The patients were equally divided into two groups. The first group was treated by benzoyl peroxide while the second group was treated by IPL. For both therapies, patients experienced a significant reduction in the mean of the inflammatory lesion counts over the treatment period. Comparing the effects of both therapies, BP produced better results than IPL. The difference in the results was statistically significant at the midpoint of the study. However, this difference was insignificant at the end of study. Treatment with both benzoyl peroxide and IPL resulted in considerable improvement of the acne after 5 weeks of treatment. Comparing the effects of both therapies, BP produced better results than IPL. The difference in the results was statistically significant at the midpoint of the study. However, this difference was insignificant at the end of study.