64排螺旋CT冠脉成像在冠心病诊断中的应用

目的 评价64排螺旋CT冠状动脉(冠脉)成像(CTA)在冠心病诊断中的应用价值.方法 以选择性冠脉造影(SCA)结果为金标准,采用64排螺旋CT对68例疑诊冠心病患者的冠脉主干及主要分支272节段进行重建和分析,评价其诊断冠心病的灵敏度和特异度.结果 CTA能够清晰显示冠脉主干及其分支狭窄、钙化、开口起源异常及桥血管病变,CTA发现钙化病变52节段,SCA仅发现钙化病变35节段.CTA诊断冠脉病变的灵敏度96.33%,特异度98.16%,阳性预测值97.22%,阴性预测值97.56%.其中对左主干、左前降支病变及＞75%的病变灵敏度最高,分别达到100%和94.4%.结论 CTA对冠脉狭窄病变、桥血管、开口畸形、支架管腔均显影良好,对冠心病诊断有较高的准确性,对钙化病变诊断率优于冠脉造影,可以作为冠心病高危人群无创性筛选检查及冠脉支架术后随访手段.     

CT冠状动脉成像与冠状动脉造影诊断冠心病对照研究

目的 探讨64层螺旋CT冠状动脉成像与冠心病的共性及差异,为临床诊断提供依据。资料与方法 49例拟诊为冠心病的患者先后行64层螺旋CT冠状动脉成像机冠状动脉造影检查,依据美国心脏病学会15段分段法,评价所有有效节段,并将两者进行对比分析。结果 共评价493段冠状动脉血管,其中29段血管CT冠状动脉成像与CAG结果不符;以CAG作为“金标准”,CT冠状动脉成像检出冠状动脉狭窄的敏感度、特异度、阳性预测值和阴性预测值分别为91.6%、95.4%、91.0%和95.7%。结论 64层螺旋CT冠状动脉成像与CAG在诊断冠心病方面有较高的一致性,64层螺旋CT冠状动脉成像可以对斑块性质做出评价,但对小血管狭窄的评估不及CAG。     

64排螺旋CT对冠心病的诊断价值

目的研究64排螺旋CT冠状动脉成像对冠状动脉疾病的诊断价值。方法搜集128例可疑或已确诊为冠心病的患者进行64排螺旋CT扫描和常规冠状动脉造影,然后对2种检查方法的结果进行对比分析。结果128例患者共有1920个冠状动脉节段可用于评价,结果显示64排螺旋CT诊断冠状动脉病变的敏感性为92%,特异性为94%,阳性预测值为82%,阴性预测值为96%。结论64排螺旋CT对冠心病的诊断及病变程度的评估具有较高的准确性、特异性和敏感性。     

多层螺旋CT无创性冠状动脉造影对冠状动脉疾病的诊断价值

目的:探讨16层螺旋CT冠状动脉造影对冠状动脉病变的临床诊断价值。方法:57例疑似冠状动脉病变的患者行16排螺旋CT检查和冠状动脉造影,不包括5例为冠状动脉支架置入术后(支架12个)。将冠状动脉分为13个节段,分析所有管腔大于2mm的节段,评价图像是否能满足管腔评价。管腔狭窄大于50%认为有意义,以常规冠状动脉造影作为金标准,比较16层螺旋CT在诊断有意义的冠状动脉狭窄方面的敏感性、特异性、阳性预测值、阴性预测值。结果:在所有638个节段中,588个节段(占92.16%)能够满足冠状动脉管腔评价。对于16层螺旋CT能够显示有意义冠状动脉狭窄,与ICA相对照,若以动脉节段计数,MSCT显示中度以上狭窄的敏感性、特异性、阳性预测值、阴性预测值和准确度分别为93.61%、91.11%、89.79%、98.12%和94.63%。以动脉主干计数,MSCT显示中度以上狭窄的敏感性、特异性、阳性预测值、阴性预测值和准确度分别为92.82、、91.31%、80.43%、97.37%和82.08%。以患者计数,MSCT显示中度以上狭窄的敏感性、特异性、阳性预测值、阴性预测值和准确度分别为94.73%、90.00%、93.01%、92.99%和82.75%。结论:16层螺旋CT结合回顾性心电门控技术冠状动脉成像无创、简单易行。既能显示管腔情况又能显示冠脉管壁,弥补了ICA的不足;经严格控制影响因素,具有较高的敏感性和特异性,较高的阴性预测值可避免不必要的有创性检查。对支架术后的随访也有较高的应用价值,对血管变异的显示直观确切。可作为一种有效的筛查和随访手段应用于临床。     

64层螺旋CT冠状动脉成像与冠状动脉造影的对比研究

目的 评价64层螺旋CT冠状动脉造影对冠状动脉疾病的临床诊断价值.方法 59例临床诊断或可疑冠心病患者行64层螺旋CT冠状动脉成像检查,并以冠状动脉造影结果作为对照,分段评价结果,冠状动脉狭窄≥50%为阳性病变.分析64层螺旋CT冠状动脉血管成像(CTA)诊断冠状动脉狭窄的敏感性、特异性、阳性预测值及阴性预测值.结果 共评价741段冠状动脉,64层螺旋CT冠状动脉血管成像用于诊断冠心病的敏感性、特异性、阳性预测值、阴性预测值分别为58.8%、97.7%、76.9%、94.8%.结论 64层螺旋CT冠状动脉血管成像有较高的诊断准确性,可以作为评价冠状动脉狭窄的一种无创检查方法.     

64层螺旋CT冠状动脉成像与冠状动脉造影的对比研究

目的评价64层螺旋CT冠状动脉成像诊断冠状动脉狭窄的准确性。方法 50例患者先后进行64层螺旋CT冠状动脉成像和冠状动脉造影检查,以冠状动脉造影为诊断冠状动脉疾病的"金标准",比较CT冠状动脉成像的符合率,评价64层螺旋CT冠状动脉成像诊断冠心病的准确性。结果 64层螺旋CT冠状动脉成像评价冠状动脉狭窄程度大于或等于50%的敏感性为98.6%,诊断狭窄程度小于50%的敏感性为87.0%,诊断冠状动脉狭窄的特异性为92.5%,阴性预测值为97.7%。结论 64层螺旋CT冠脉成像诊断冠状动脉狭窄有很高的准确率。     

64层螺旋CT冠状动脉成像与冠状动脉造影对照初步研究

目的评价64层螺旋CT(64SCT)冠状动脉成像检出冠状动脉狭窄性病变的准确性。方法连续30例临床怀疑冠心病的患者(男21例,女9例,平均年龄54.6岁)行64SCT冠状动脉成像检查,同期行选择性冠状动脉造影(SCA)。64SCT原始数据均行容积再现(VR)、曲面重组(CPR)、最大密度投影(MIP)及横断面重建。对2种方法评价冠状动脉结果进行对照研究,探讨64SCT冠状动脉成像检出冠状动脉狭窄病变的准确性。结果30例冠状动脉造影显示的396节段冠状动脉(直径≥2mm)图像中,64SCT提供优良图像可供分析为385节段,可评估率为97.2%。与SCA对照分析,评价冠状动脉狭窄(≥50%狭窄)的敏感性、特异性、阳性预测值以及阴性预测值分别为96.22%、94.56%、89.44%和96.88%。对冠状动脉≥50%狭窄的检出准确率为95.90%。结论64SCT对检出冠状动脉狭窄有较高的准确性,作为无创性检查方法,可用于冠心病的初步筛选。     

64层螺旋CT与DSA在冠状动脉造影中的应用分析

目的 探讨并对比64层螺旋CT （MSCT）冠状动脉造影与DSA对冠状动脉各节段病变的检测情况.方法 收集2010年12月～2011年12月我院收治的92例患者64层螺旋CT和DSA检查临床资料.观察并比较两种方法对冠状动脉各阶段狭窄病变的检测情况.结果 CT检出冠脉狭窄的敏感度、特异度、阳性预测值和阴性预测值分别为91.1％、94.6％、90.0％和95.3％.经过与DSA对照,MSCT检测出的冠状动脉各段病变数、钙化斑块及非钙化斑块数与DSA相近.结论 64层螺旋CT与DSA在诊断冠状动脉各段病变及狭窄程度上准确度相似,具有一致性.64层CT在冠脉狭窄病变中具有重要的临床价值,值得在临床上广泛应用.     

64层螺旋CT冠状动脉造影对冠状动脉狭窄的诊断价值

目的：评价64层螺旋CT冠状动脉造影（64-slice CTCA）诊断冠状动脉狭窄的临床应用价值。方法：对120例临床怀疑冠状动脉疾病及支架置入术、冠脉搭桥术后的患者进行64层螺旋CT冠状动脉成像。采用回顾性心电门控扫描,并采用曲面重建、多平面重组,容积再现及最大密度投影技术显示冠状动脉主干及分支,其中30例患者近期行传统冠状动脉造影（CCA）。结果：120例患者可评价冠脉节段1377个,可满足诊断的冠脉节段1341个,占97．39％。30例患者近期行CCA检查,MSCTCA诊断冠脉狭窄节段103个与CCA相符,占88．03％,显示轻、中、重度狭窄及血管闭塞与CCA符合率分别为77．8％、93．3％、91．6％、77．8％,得出64SCTCA诊断冠脉狭窄敏感性97．52％,特异性96．02％,阳性预测值95．16％,阴性预测值96．01％。结论：64层螺旋CT冠状动脉造影在诊断冠状动脉疾病方面有很高的诊断价值,可以成为筛查、排除冠状动脉病变及支架、搭桥术后随访的常规检查方法。     

64排128层螺旋CT冠状动脉成像与冠脉造影比较分析

目的 探讨64排1 28层螺旋CT在冠状动脉病变中的应用价值.方法 选择2011年6月～2012年10月间在我院影像中心接受螺旋CTA检查的冠心病患者100例为研究对象,所有患者均于入院3d内完成冠状动脉螺旋CTA检查及冠脉造影.观察冠状动脉螺旋CTA图像特征,以冠脉造影为金标准,分析64排128层螺旋CTA对冠脉狭窄诊断的敏感性、特异性、阳性预测率及阴性预测率.结果 100例患者64排128层螺旋CT冠脉成像均取得满意的检查图像.以冠脉造影为金标准,64排128层螺旋CT冠脉成像显示轻度冠脉狭窄数量多于冠脉造影,中度及重度冠脉狭窄数量少于冠脉造影,经卡方检验,无统计学差异（P＞0.05）.64排128层螺旋CT冠脉成像共显示146处冠状动脉狭窄（≥50％）.以冠脉造影为金标准,64排128层螺旋CT冠脉成像对冠状动脉狭窄（≥50％）诊断的敏感性为96.4％（137/142）,特异性为96.8％（274/283）,阳性预测率为93.8％（137/146）,阴性预测率为98.2％（274/279）.结论 64排128层螺旋CT冠脉成像可以与冠脉造影相媲美,具有很高的敏感性、特异性、阳性预测率及阴性预测率,值得临床推广应用.     

64层螺旋CT冠状动脉成像诊断冠状动脉疾病的临床应用

目的：探讨64层螺旋CT冠状动脉成像（64SCTCA）诊断冠状动脉中、重度狭窄（管腔直径≥50%）的临床应用价值。方法：收集140例患者64SCTCA的完整资料,依据AHA15段分段法,对有效节段进行评价,并以近期实施的选择性X线冠状动脉造影（CAG）结果为＂金标准＂进行对照分析,了解64SCTCA诊断冠状动脉中、重度狭窄的敏感性、特异性和准确度。结果：所有病例可用于评估的1360节段冠状动脉中,共显示病变284节段,其中272节段得到CAG证实,18节段64SCTCA显示中度狭窄而CAG显示仅为轻度狭窄,6节段64SCTCA显示正常或轻度狭窄而CAG显示中度狭窄,23节段重和中度狭窄的评估两者结果不一致,64SCTCA诊断冠状动脉中、重狭窄的敏感性为95.77%、特异性99.07%、准确度为98.68%。结论：64SCTCA是一种安全可靠且准确有效的冠状动脉检查方法,可作为临床进行CAG检查前的有效筛选手段。     

无常规心率控制下64排螺旋CT诊断冠状动脉狭窄的应用价值

目的 以有创性冠状动脉造影(ICA)为"金标准",评估无常规心率控制下64排螺旋CT冠状动脉成像(CTA)诊断冠状动脉狭窄的可靠性.资料与方法 35例患者先后行64排螺旋CT冠状动脉CTA和ICA,CTA扫描前所有患者均未常规控制心率.在未获知ICA结果的情况下,两位观察者独立对CTA结果作出评价.以冠状动脉管腔狭窄程度≥50%作为确定冠状动脉狭窄存在的标准.结果 ICA共显示75处冠状动脉管腔狭窄.64排螺旋CT冠状动脉CTA诊断冠状动脉狭窄的敏感度、特异度、阳性预测值及阴性预测值分别为:97.3%(73/75), 98.9%(468/473),93.6%(73/78)和99.6%(468/470).结论 在无常规心率控制条件下,64排螺旋CT冠状动脉CTA诊断冠状动脉狭窄仍具有很高的准确性.     

多层螺旋CT在心肌桥诊断中的应用及优势

目的 探讨多层螺旋CT(MSCT)在心肌桥中的诊断能力.方法 对51例临床怀疑为冠状动脉粥样硬化性心脏病的患者进行了MSCT、常规冠状动脉造影(CAG)以及血管内超声检查(将后2种检查方法统称为创伤性技术),共82支冠状动脉,其中的80支冠状动脉无明显伪影,可供评价.分别统计MSCT对心肌桥检出的敏感度、特异度和准确度.观察者间的一致件检验采用Cohen Kappa检验方法.结果CAG及血管内超声共发现26例心肌桥,所有心肌桥均发生于左前降支中段附近.MSCT正确检出26例前降支心肌桥巾的23例,其敏感度88%(23/26),特异度96%(52/54),准确度94%(75/80),2名医师对心肌桥的检出Kappa值为0.62.MSCT尚检出2例心肌桥,为创伤性技术所漏诊.将创伤性技术和MSCT综合结果作对照,则MSCT心肌桥检出的敏感度、特异度和准确度分别为89%(25/28)、91%(21/23)和90%(46/51).结论MSCT作为一种无创性成像方法应用于心肌桥的诊断,方法可行,结果可靠.     

Coronary artery bypass graft imaging using ECG-gated multislice computed tomography: comparison with catheter angiography

AIM: To compare the value of multislice computerized tomography (MSCT) in imaging coronary artery bypass grafts (CABGs) by direct quantitative comparison with standard invasive angiography. METHODS: Using MSCT, 50 consecutive patients who had previously undergone CABG surgery and had recently undergone invasive angiography for recurrent angina pectoris, were studied further using MSCT after intravenous injection of non-ionic contrast agent; cardiac imaging was performed during a single breath-hold. Graft anatomy was quantified, using both quantitative coronary angiography (QCA) and MSCT, by different investigators blinded to each other. Reproducibility was quantified using the standard error of the measurement expressed as a percentage in log-transformed values (CV%) and intraclass correlation (ICC). RESULTS: All 150 grafts were imaged using MSCT; only 4 patent grafts were not imaged using selective angiography. Good agreement was achieved between MSCT and QCA on assessment of proximal anastomoses (CV% 25.2, ICC 0.84), mid-vessel luminal diameter (CV% 15.5, ICC 0.91) and aneurysmal dilations (CV% 14.3). Reasonable agreement was reached on assessment of distal anastomoses (CV% 26.7, ICC 0.66) and categorization of distal run-off (ICC 0.73). Good agreement was observed for stenoses of over 50% luminal loss (CV% 8.7, ICC 0.97) but agreement on assessment of less severe lesions was poor (CV% 208.7, ICC 0.51). CONCLUSION: This study demonstrates that CABGs can be quantitatively evaluated using MSCT, and that significant lesions present in all CABG segments can be reliably identified. Agreement between MSCT and QCA for lesions of less than 50% luminal loss was poor.     

Diagnostic value of 64-slice CT angiography in coronary artery disease: a systematic review

PURPOSE: To perform a systematic review of the diagnostic value of 64-multislice CT (MSCT) angiography in the detection of coronary artery disease (CAD) when compared to conventional coronary angiography. MATERIALS AND METHODS: A search of PUBMED and MEDLINE databases for English literature was performed. Only studies with at least 10 patients comparing 64-slice MSCT angiography with conventional coronary angiography in the detection of CAD were included. Diagnostic value of MSCT angiography compared to coronary angiography was compared and analysed at segment-, vessel- and patient-based assessment. RESULTS: Fifteen studies met selection criteria and were included for analysis. Pooled sensitivity, specificity, positive predictive value and negative predictive value as well as 95% confidence interval (CI) were 97% (94 and 99%), 88% (79 and 97%), 94% (91 and 97%), and 95% (90 and 99%) for patient-based assessment; 92% (85 and 99%), 92% (85 and 99%), 78% (66 and 91%) and 98% (96 and 99%) for vessel-based assessment; 90% (85 and 94%), 96% (95 and 97%), 75%(68 and 82%) and 98% (98 and 99%) for segment-based assessment, respectively. No significant difference was found in the diagnostic accuracy of 64-slice CT in the detection of CAD when comparison was performed either among four main coronary arteries, or between proximal and middle or distal segments (p>0.05). CONCLUSION: Our results showed that 64-slice CT angiography has a high-diagnostic value in the detection of CAD. Severe coronary artery calcification seems to be the major factor affecting the visualisation and assessment.     

64层螺旋CT在冠状动脉疾病诊断中的价值

目的 评价64层螺旋CT冠状动脉成像（64SCTCA）在诊断冠状动脉疾病的临床价值。方法 搜集100例患者64SCTCA的完整资料，并以近期实施的选择性X线冠状动脉成像（CCA）结果为金标准进行对比，对64SCTCA显示的冠状动脉主支及主要分支情况进行分级评估。结果 所有病例可用于评估的920支冠状动脉中，共显示病变370支，其中348支得到CCA证实；22支64SCTCA诊断狭窄而CCA显示正常，另外有10例CCA确诊存在的病变而在64SCTCA上未能显示，得出64SCTCA诊断冠状动脉病变的敏感性为97．2％，特异性为96．0％，阳性预测值为94．0％，阴性预测值为98．1％。经配对χ^2检验，P=0．052，证明两种检查方法在发现冠状动脉病变方面差异无统计学意义。在显示病变程度上，64SCTCA评估与CCA完全一致者311支，准确性86．8％。在64SCTCA结果中，共有59支病变在程度上的评价与CCA结果不符合。结论 64SCTCA在显示冠状动脉病变时，具有较高的敏感性和特异性，并且对于病变程度的评估也比较准确，适合用于临床怀疑冠心病的患者CCA前的筛选检查。     

Normal anatomy of the vessels of the heart with 16-row multislice computed tomography

Nowadays, cardiac imaging is not part of the clinical routine for the radiologist. Multislice Computed Tomography (MSCT) with 4 rows allowed to start the non invasive evaluation of coronary arteries. The introduction of 16-row MSCT has significantly improved the performance and diagnostic accuracy of this technique, so far that MSCT angiography has been advocated as a potential clinical tool for the study of coronary artery disease. Therefore, it is mandatory to understand normal cardiac and coronary anatomy in order to evaluate the presence and severity of coronary artery disease. The anatomical visualisation provided by MSCT differs from the one of conventional coronary angiography because it is not a simple "lumenology" but it is capable to provide information on the vessel wall, until now only achieved by invasive techniques such as intravascular ultrasound or optical coherence tomography, and on neighbouring structures. Aim of this works is to provide the basics of anatomy of the vessels of the heart applied to MSCT.     

64层螺旋CT冠状动脉成像诊断冠状动脉狭窄的初步探讨

目的：探讨64层螺旋CT（MSCT）冠状动脉成像对冠状动脉狭窄的诊断价值。方法：53例冠心病患者同期均行64层螺旋CT冠状动脉成像和常规冠状动脉造影（CCA）,以CCA的诊断结果作为金标准,采用美国心脏协会冠状动脉改良分段法,分析745个冠状动脉节段MSCT图像质量及对冠状动脉狭窄的显示情况,得出有意义病变（冠状动脉狭窄率≥500%）MSCT诊断的正确性,并分析钙化对其影响。结果：587个冠状动脉节段图像可以满足诊断要求,158个节段因运动伪影（27个节段）或管壁严重钙化（131个节段）无法进行血管评价。MSCT诊断冠状动脉狭窄的敏感度为93．4％、特异度为97．9％、阳性预测值为93．9％、阴性预测值为97．7％。钙化积分≥1000的患者,MSCT诊断冠状动脉狭窄的特异度、敏感度、阳性预测值、阴性预测值分别为74％、82％、68％、96％。结论：64层螺旋CT冠状动脉成像是一种快速、安全、无创的检查方法,与常规冠状动脉造影检查结果有较好的一致性,可以作为临床怀疑冠心病患者的首选检查方法。     

Non-invasive detection of significant coronary artery disease with multi-section computed tomography angiography in patients with suspected coronary artery disease

AIM: The objective of this prospective study was to compare the accuracy of multi-section computed tomography (MSCT) coronary angiography with invasive selective coronary angiography in the detection of significant coronary stenosis (> or =50% lumen diameter narrowing). METHODS: Thirty consecutive patients (mean age 59+/-10 years) with suspected coronary artery disease underwent both invasive coronary angiography and MSCT using a 40-section multidetector row machine with temporal resolution of 53ms. Reconstruction images were performed in eight phases of the cardiac cycle. Images of MSCT and invasive coronary angiography were analysed using the 16-segment model of the American Heart Association. RESULTS: A total of 480 segments from 30 patients were evaluated. Coronary segments distal to a vessel occlusion and segments with coronary stent were not considered for analysis (20 segments in total). Ninety-four (20.4%) segments showed significant (> or =50%) stenosis by invasive coronary angiogram. The accuracy of coronary MSCT was computed on a per segment basis. Average sensitivity, specificity, positive predictive value, and negative predictive value of MSCT were 99, 98, 94, and 99%, respectively. CONCLUSION: This study demonstrated that MSCT is as reliable as coronary angiography at detecting significant obstructive coronary artery disease. In selected groups of patients, it may replace the more invasive and potentially more dangerous conventional coronary angiography.     

64层CT冠状动脉成像检测冠状动脉畸形价值初探

目的:探讨64层CT冠状动脉成像检测冠状动脉畸形的方法和诊断价值.方法:采用容积再现(VR)、最大密度投影(MIP)以及多平面重组(MPR)等方法分析2672例64层CT冠状动脉成像资料,总结冠状动脉畸形的发生率和CT表现.结果:2672例中发现冠状动脉起源异常18例(0.67%),其中发生于右冠11例(61.11%),左冠7例(38.89%);发现冠状动脉瘘7例(0.26%).结论:64层CT冠状动脉成像能够准确全面地显示冠状动脉的异常起源、走行和终止.