生存质量在中医药治疗恶性肿瘤领域中的应用研究

生存质量(quality of life,QOL)是近年医学领域颇受重视的课题.世界卫生组织(WHO)对生存质量的定义为:不同文化和价值体系中的个体对他们的目标、期望、标准以及所关心事情有关的生活状况的体验.     

新疆汉族与少数民族晚期食管癌患者放疗前后生活质量比较

新疆维吾尔自治区是一个多民族聚集的地区,少数民族食管癌占一定比例[1],其中哈萨克族和维吾尔族在食管癌的发病率最高,已被列为新疆特高发恶性肿瘤.2007年1月至2010年6月我们用欧洲癌症研究与治疗组织(European organization for research and treatment of cancer,EORTC)生活质量核心问卷(quality of life questionnaire-core-30)(EORTC-QLQ-C30)中文版、维吾尔语版、哈萨克语版[2]调查汉族与维吾尔族和哈萨克族晚期食管癌放疗患者放疗后生活质量,现将结果报道如下.     

肿瘤相关性贫血的研究进展

肿瘤相关性贫血(cancer-related anemia,CRA)指由于肿瘤本身或肿瘤患者经治疗引起的贫血.据统计,贫血的发生率与肿瘤的类型、严重程度有关,在接受放、化疗的肿瘤患者中,贫血的发生率为70％～90％[1].CRA不但降低了患者的生活质量(quality of life,QOL),也是预后不良的指标之一,故应积极纠正CRA.作者对CRA的研究进展进行如下综述.     

鼻咽癌患者生存质量量表QOL-NPC研制中的条目筛选

背景与目的:目前,全世界广泛使用癌症患者生存质量量表、头颈癌生存质量量表、SF-36等非特异性的量表去测定鼻咽癌患者的生存质量量表;鼻咽癌患者特异性量表(scale of quality of life for nasopharyngeal carcinoma,SQOL-NPC)至今未进行更新.本研究的目的在于研制符合中国国情的鼻咽癌患者生存质量(quality of life for nasopharyngeal carcinoma,QOL-NPC)评价量表.方法:参照WHO关于生存质量的定义,在文献复习的基础上,听取肿瘤医护人员及专家、生存质量专家、鼻咽癌患者的意见,制定初步的量表.2007年1～2月,在中山大学肿瘤防治中心随机抽取鼻咽癌患者433例,采用离散趋势、相关系数、因子分析和克朗巴赫系数统计学方法筛选条目.结果:研制出QOL-NPC量表,该量表包含身体机能(physical domain,PH)、心理精神状况(psychological domain,PS)、社会关系(social domain,SO)、副作用(side effect domain,SE)4个领域共30个条目.结论:QOL-NPC量表反映了WHO关于生存质量的内涵和鼻咽癌患者的特殊问题,并按程序化方式进行条目筛选,可以认为该量表适合评价鼻咽癌患者的生存质量.     

Investigation of quality of life in patients with lung cancer by the EORTC QLQ-C30 (V3.0) Chinese version

Objective To explore quality of life (QOL) and its influencing factors in patients with lung cancer.
Methods A QOL questionnaire (European Organization for Research and Treatment of Cancer [EORTC]...     

Targeted Therapy in Metastatic Breast Cancer:Highlights from ASCO 2009

Background: Metastatic breast cancer (MBC) is an incurable disease. The medium survival of MBC is 2-3 years with the aim of treatment focusing on symptom control and quality of life (QOL). Despite the availability of many     

乳腺癌患者术后化疗期情绪障碍与健康相关生活质量研究

目的 乳腺癌患者生活质量提升是临床治疗的考核目标之一.本研究关注乳腺癌患者化疗期间的心理情绪和生活质量改变及其影响因素,探讨乳腺癌患者术后治疗期的负性情绪与健康相关生活质量(health related quality of life,HRQoL)之间的关系.方法 以2014-11-13-2015-04-21在烟台市毓璜顶医院(31例)和淄博市中心医院肿瘤科(69例)接受术后化疗的乳腺癌患者为研究对象,研究采用横断面设计,使用一般情况调查表、医院焦虑抑郁量表(hospital anxiety and depression scale,HAD)和欧洲癌症研究与治疗组织开发的癌症患者生活质量核心问卷(quality of life questionnaire-core 30,QLQ-C30)对100例术后化疗期乳腺癌患者进行问卷调查;采用统计软件SPSS 19.0对数据进行分析处理.结果 45例(45％)的乳腺癌患者化疗期患者焦虑得分≥8分,37例(37％)的患者抑郁得分≥8分,年龄、教育水平、医疗费用来源和长期居住地对焦虑的影响差异均有统计学意义,P＜0.05;婚姻状况对抑郁的影响差异有统计学意义,P＜0.05;患者整体健康状况得分为69.42±15.03,医疗费用来源对其有显著影响,P＜0.05;患者焦虑抑郁反应与躯体功能、角色功能、情绪功能及疲乏和恶心呕吐等躯体症状呈显著负相关,P＜0.05.结论 部分乳腺癌患者化疗期存在负性情绪反应且受到社会人口学因素影响;负性情绪对患者的健康和生活质量产生影响.     

国外文摘(英文)

Complementary therapy use and quality of life in persons with high-gradegliomasJ Neurosci Nurs.2006,38(4):212-220.Fox S,Laws ER Jr,Anderson F Jr,Farace E.University of Virginia School of Nursing,Charlottesville,USA.foxsherry@aol.comStudies have indicated …     

乳腺癌生存质量测量量表及其运用

生存质量(Quality of life,QOL)是指与健康有关的生活质量,是个体根据其所取的文化背景、价值系统决定对自身生活的主观满意度,主要受个体目标、期望值、标准和个体的关注点等因素的影响.     

大肠癌的治疗

在消化系统癌肿的治疗中,大肠癌的治疗尚无根本变化。随着大肠癌患者增多,诊断技术进步,癌特性阐明,治疗效果改善,在选择治疗中应考虑患者的生活质量(quality of life)问题。早期癌的治疗 1.内镜下息肉切除 98％早期大肠癌为隆起型,粘膜内(m)癌无淋巴结转移,粘膜下(sm)癌有少数淋巴结转移,约为7％。尤其Ⅰp和Ⅰsp型早期癌淋巴     

生活质量评价在中医肿瘤临床治疗中的应用

生活质量(quality of life,QOL)是在WHO提倡的健康新概念:"人在躯体上精神上及社会生活中处于一种完好的状态,而不仅仅是没有患病和衰弱"的基础上提出的,是医学模式由单纯的生物医学模式向生物一心理一社会综合医学模式转变的体现.生活质量评估通过对患者躯体感觉及功能、心理状态、社会职能及疾病本身和治疗所致的症状和体征诸方面所作的综合评价(包括患者对以上诸方面的自我评价),从一个新的角度评定治疗效果.同以往传统疗效评定标准不同,它更重视患者的主观感受,而不是仅仅将临床客观指标作为评价标准.     

The efficacy of the inhalation of an aerosolized Group A streptococcal preparation in the treatment of lung cancer

Objective:To observe the efficacy of the inhalation of an aerosolized group A streptococcal(GAS) preparation in treating orthotopic lung cancer in mouse models and assess the feasibility,safety,and effectiveness of this administration mode for lung cancer.Methods:Lewis lung carcinoma(LLC) cell strains were administered via intrathoracic injection to establish orthotopic lung cancer mouse models.After the tumor-bearing models were successfully established,as confirmed by computed tomography,the mice were administered by inhalation with an aerosolized GAS preparation(GAS group) or aerosolized normal saline(control group).The anti-tumor effect of the aerosolized GAS preparation was evaluated histologically;meanwhile,the survival and quality of life were compared between these two groups.Results:The aerosolized GAS preparation showed remarkably anti-tumor effect,causing the necrosis of the orthotopic lung cancer cells in tumor-bearing mice.Furthermore,mice in the GAS group had significantly better quality of life and longer survival than those in control group.Conclusions:The inhalation of aerosolized GAS preparation may be a feasible,safe and effective solution for lung cancer.     

Double-tract reconstruction is superior to esophagogastrostomy in controlling reflux esophagitis and enhancing quality of life after proximal gastrectomy: Results from a prospective randomized controlled clinical trial in China

Objective: The aim of this study was to prospectively compare double-tract reconstruction(DTR) and esophagogastrostomy(EG) after proximal gastrectomy(PG) regarding the incidence of reflux esophagitis, quality of life(QOL), nutritional status and surgical safety.Methods: This study was a randomized controlled trial. Patients eligible for PG were enrolled and randomly assigned to the EG group and DTR group. The characteristics of patients, parameters for surgical safety, incidence of reflux esopha...     

参附注射液联合长春瑞宾提高老年非小细胞肺癌生活质量的随机对照研究(英文)

Objective: The present study aimed to investigate the efficacy of Shenfu injection plus vinorelbine on the promotion of the quality of life (QOL) in elderly non-small cell lung cancer (NSCLC) patients. Methods: A randomized single blind trial method was used. Forty-six patients with stage IIIB–IV of NSCLC were randomly divided into experimental group and control group. In the experimental group, the patients were treated with 50 mL Shenfu injection from day 1 to 14, plus vinorelbine (NVB) 25 mg/m2 on day 1 ...     

生存质量评估在鼻咽癌放疗后生存者的临床价值

生存质量(Quality of life)一般译为生存质量、生活质量或生命质量,简称为QOL。一、生存质量概念的形成和发展历史1947年WHO首先提出“健康”新概念,健康不仅仅指一个人无病或虚弱,而是指身体上、精神上和社会活动上有一个良好状态。从此,对健康的认识上,特别强调多维性和生     

直肠癌长期生存患者生活质量研究进展

随着现代医学模式的转变,恶性肿瘤治疗的目的不仅是通过各种治疗延长生命,更重要的是改善患者的生活质量(quality of life,QOL)。1985年美国食品和药品管理局提出将QOL作为抗癌新药评定的重要指标,1989年又决定将QOL的测定作为肿瘤临床试验和慢性疾病治疗效果的评价方法。20世纪 90年代以来,国际上已将癌症患者的QOL作为临床研究的终点,QOL将成为全面评价癌症疗效的重要标准而被广泛应用。     

Bevacizumab as therapy for radiation necrosis in four children with pontine gliomas

PURPOSE： Diffuse pontine gliomas are a pediatric brain tumor that is fatal in nearly all patients. Given the poor prognosis for patients with this tumor, their quality of life is very important. Radiation therapy provides some palliation, but can result in radiation necrosis and associated neurologie decline. The typical treatment for this necrosis is steroid therapy. Although the steroids are effective, they have numerous side effects that can often significantly compromise quality of life. Bevacizumab, an antibody against vascular endothelial growth factor, has been suggested as a treatment for radiation necrosis.     

Progress of transformational therapy in colorectal liver metastases

Colorectal cancer liver metastases(CLM) treatment is very important given the high incidence of colorectal cancer with liver metastases, which are primarily treated by surgical resection. Transformational therapy such as systemic chemotherapy, hepatic arterial infusion(HAI), portal vein embolization(PVE), ablation therapy, and targeted therapy, should be applied to CLM patients who are unable to undergo immediate surgery to improve patients’ survival and quality of life.     

Predicting Bone Metastasis for Breast Carcinoma

Bone metastasis is the most common distant metastasis in advanced breast cancer patients which has significant impact on patient's quality of life. Breast carcinomas are a group of very heterogeneous tumors and the