共查询到18条相似文献,搜索用时 171 毫秒
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声动力疗法(SDT)是一种利用声敏剂和低强度超声(US)结合治疗恶性肿瘤的新型无创治疗方法,SDT由光动力疗法(PDT)发展而来.由于超声波相对于光在组织中的传输深度更深,且声敏剂经过诱导而具有靶向性,同时还能利用超声波对声敏剂进行实时监测,所以SDT在肿瘤部位定位和激活深部组织内的敏化剂方面有着显著的优势.因此,与P... 相似文献
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声动力疗法(sonodynamic therapy,SDT)是一种在光动力疗法(photodynamic therapy,PDT)基础上发展起来的非侵入性治疗方法,可以选择性、特异性地杀伤肿瘤细胞。最新的研究显示,声动力疗法在治疗实体肿瘤、白血病、动脉粥样硬化,消除增生性瘢痕以及抗病原微生物等方面显示出极大的潜力。本文将从以下四个方面对声动力疗法的研究进展予以综述:声动力疗法的机制,声动力疗法的应用,声动力疗法与其他治疗方法的联合应用,声动力疗法的现状和展望。 相似文献
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胆管癌是起源于胆管上皮的恶性肿瘤,发病率逐年升高,其早期症状不典型,诊断率低,就诊时大多已是晚期,失去最佳的手术时期。目前对于不可切除性肝外胆管癌的保守治疗方法有支架置入、射频消融、放疗和化疗、靶向、免疫治疗等,但由于胆道肿瘤恶性程度高,易产生耐药,且新兴治疗方式的获益人群有限,因此我们亟需探索新的治疗策略来突破此瓶颈。光动力疗法作为一种治疗胆管癌的新手段,其临床应用效果引起广泛关注。本文主要针对光动力治疗原理、光动力与其他治疗方式的联合使用,尤其是光动力联合新兴的免疫和靶向治疗进行归纳总结,并阐述目前国内外光动力治疗研究的热点方向,为临床及科研提供参考。 相似文献
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光动力疗法(PDT)是一种新兴的治疗方法,近年来被试用于浅表膀胱癌的治疗.综述光动力疗法治疗膀胱癌的原理、临床适应证、疗效、不良反应及发展前景. 相似文献
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谷龙杰 《国外医学(肿瘤学分册)》2003,30(1):70-73
光动力疗法(PDT)是一种新兴的治疗方法,近年来被试用于浅表膀胱癌的治疗。综述光动力疗法治疗膀胱癌的原理、临床适证证、疗效、不良反应及发展前景。 相似文献
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非黑色素瘤皮肤癌是人类最常见的恶性肿瘤之一. 其发病率最高的是基底细胞癌,其次为易发生转移的鳞状细胞癌. 光动力疗法应用于人类肿瘤研究已经有三十多年的历史,作为一种非创伤性的治疗方法,它的优点是可以局部用药并保护治疗区域的美观性. 在很多临床病例研究中,光动力疗法显示了其对非黑色素瘤皮肤癌的治疗作用. 本文综述了光动力疗法治疗非黑色素瘤皮肤癌的现有研究成果,为其在临床应用提供参考依据. 相似文献
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Improving the effectiveness of cancer treatment has become a central concern for the public. In recent years, in order to maximize the efficiency of cancer treatment, photodynamic therapy (PDT) and sonodynamic therapy (SDT) have received widespread attention. Chlorin e6 (Ce6) is a fluorescent dye with strong optical properties and excellent photoconversion efficiency under near-infrared light irradiation, which has been widely used in PDT in recent decades due to its superior antitumor ability. Of note, Ce6 can be used as a sonosensitizer for SDT, which generates large amounts of reactive oxygen species (ROS) for tumor treatment after ultrasound activation. These strategies can selectively kill local tumors without endangering normal tissues. At present, there are more and more researches on optimizing the pharmacological properties of Ce6-based therapeutic agents. Therefore, this review focuses on the properties of Ce6 and the research progress of various nano-scale delivery strategies based on Ce6 in tumor treatment. At last, we summarized the positive impact and bright prospects of Ce6-based nanomaterials in cancer treatment applications. 相似文献
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声动力疗法(sonodynamic therapy,SDT)因损伤较小、选择性较高等特点在肿瘤的治疗方面被广大学者、专家所关注。目前研究发现,声动力治疗肿瘤有多种机制,其中自由基离子理论被认为是主要作用机制。自由基离子理论主要与活性氧(reactive oxygen species,ROS)有关,而ROS是近年来各个医学领域的研究热点。氧化应激导致ROS的产生,而不同浓度的ROS对机体的影响大不相同。氧化应激又与肿瘤的发生、发展有着密不可分的联系,在各种致癌因素的作用下,机体将生成大量ROS,如果机体没有及时把产生的活性氧清除,就可能对周围组织产生损伤,甚至出现恶变。本文阐述在SDT作用下产生的ROS与肿瘤之间的关系,以期为临床上肿瘤的治疗和预防提供新的思路。 相似文献
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光动力治疗(Photodynamic therapy,PDT)是利用光动力学反应,即在分子氧存在的情况下通过特定波长的光照射激活光敏剂,产生包括单线态氧的活性氧物质杀伤肿瘤细胞的一种治疗手段。光动力治疗肿瘤具有创伤小、选择性强、低毒性、适用性好的优点,但是,缺乏理想的光敏剂(Photosensitizer,PS),光源组织穿透深度不足,以及肿瘤组织缺氧等问题已经严重限制了光动力治疗在临床上的应用。纳米材料可解决光动力治疗中遇到的上述问题,因此近来在肿瘤光动力治疗中得以广泛应用,本综述将对纳米颗粒在光动力治疗中的应用进展进行综述。 相似文献
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光动力学疗法辅助手术治疗脑恶性肿瘤 总被引:5,自引:0,他引:5
本文报告应用激光-血卟啉衍生物辅助手术治疗26例脑恶性肿瘤其中21例为恶性胶质瘤,4例为脑转移癌,1例为恶性脑膜瘤,我们认为应用4-7mg/kg体重HPD和波长630nm激光,剂量达到300Jcm^2辅助手术治疗脑恶性肿瘤未增加并发症的发生,且取得了较好的治疗效果。 相似文献
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Drug resistance is considered the most important reason for the clinical failure of cancer chemotherapy. Circumventing drug resistance and improving the efficacy of anticancer agents remains a major challenge. Over the past several decades, photodynamic therapy (PDT) and sonodynamic therapy (SDT) have attracted substantial attention for their efficacy in cancer treatment, and have been combined with chemotherapy to overcome drug resistance. However, simultaneously delivering sensitizers and chemotherapy drugs to same tumor cell remains challenging, thus greatly limiting this combinational therapy. The rapid development of nanotechnology provides a new approach to solve this problem. Nano-based drug delivery systems can not only improve the targeted delivery of agents but also co-deliver multiple drug components in single nanoparticles to achieve optimal synergistic effects. In this review, we briefly summarize the mechanisms of drug resistance, discuss the advantages and disadvantages of PDT and SDT in reversing drug resistance, and describe state-of-the-art research using nano-mediated PDT and SDT to solve these refractory problems. This review also highlights the clinical translational potential for this combinational therapy. 相似文献
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目的:比较手术、放疗和光动力治疗分别联合小剂量化疗治疗早期声门型喉癌的临床疗效。方法:回顾性分析本院收治的122例早期声门型喉癌患者的临床资料,按照治疗方法分为手术组(83例)、放疗组(20例)和光动力组(19例),均联合小剂量化疗。观察三组的3、5年总生存率、2年无瘤生存率和2年局部控制率,并进行比较。结果:8例患者失访,定为死亡或复发。 三组患者3、5年总生存率、2年无瘤生存率和2年局部控制率经比较差异均无统计学意义(均P>0.05)。3组中一共有6例患者死于喉癌,1例患者死于第二原发恶性肿瘤,1例死于其他疾病。手术组13例出现并发症,放疗组7例出现并发症,光动力组2例出现并发症。入组患者中一共有27例出现复发转移,其中4例为颈部淋巴结转移,23例为原发灶复发。手术组、放疗组和光动力组分别有15例、3例和5例出现复发,三组复发率比较差异无统计学意义(P>0.05)。结论:手术、放疗和光动力治疗联合小剂量化疗治疗早期声门型喉癌可获得相似的临床疗效。 相似文献
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Chun‐Sheng Yang Ya‐Xi Li Yong Xin Wen‐Wen Guo Zhi‐Ping Wei Yan‐Qun Liu Guan Jiang 《International journal of cancer. Journal international du cancer》2017,141(4):646-653
Melanoma is a most aggressive skin cancer with limited therapeutic options and its incidence is increasing rapidly in recent years. The discovery and application of new targeted therapy agents have shown significant benefits. However, adverse side‐effects and resistance to chemotherapy remain formidable challenges in the clinical treatment of malignant melanoma. Nanotherapeutics offers an important prospect of overcoming these drawbacks. The anti‐tumoral applications of nanomedicine are varied, including those in chemotherapy, RNA interference, photothermal therapy, and photodynamic therapy. Furthermore, nanomedicine allows delivery of the effector structures into the tumor site via passive or active targeting, thereby allowing increased therapeutic specificity and reduced side effects. In this review, we summarize the latest developments in the application of nanocarrier‐mediated targeted drug delivery to melanoma and nanomedicine‐related clinical trials in melanoma treatment. We also discuss existing problems and opportunities for future developments, providing direction and new thoughts for further studies. 相似文献