扑热息痛片致药疹1例

1 基本资料 患者,男,27岁,因头痛自服一片扑热息痛(0.3 g/片),约3 h后出现局部皮肤瘙痒难耐而就诊.查体:体温37 ℃,脉搏82次/min,呼吸20次/min,血压125/80 mm Hg.口唇红斑,下唇红斑上有2 cm×3 cm范围成片簇集血疱;双手虎口周围有4 cm×4 cm红斑,左手红斑上有0.5 cm×1cm血疱1个;左脚拇趾第一节趾骨背面有2 cm×4 cm红斑,右脚根部有3 cm×4 cm红斑.     

Efficacy of Getong Tongluo Capsule(葛酮通络胶嚢)for Convalescent-Phase of Ischemic Stroke and Primary Hypertension:A Multicenter,Randomized,Double-Blind,Controlled Trial

Objective:To evaluate whether the efficacy of Getong Tongluo Capsule(葛酮通络胶囊,GTC,consisted of total flavone of Radix Puerariae)on improving patients'quality of life and lowering blood pressure are superior to the extract of Ginkgo biloba(EGB)for patients with convalescent-phase ischemic stroke and primary hypertension.Methods:This randomized,positive-drug-and placebo-controlled,double-blind trial was conducted from September 2015 to October 2017.Totally 477 eligible patients from 18 hospitals in China were randomly assigned in a 2:1:1 ratio to the following interventions,twice a day for 12 weeks:(1)GTC 250 mg plus EGB-matching placebo 40 mg(237 cases,GTC group),(2)EGB 40 mg plus GTC-matching placebo 250 mg(120 cases,EGB group)or(3)GTC-matching placebo 250 mg plus EGB-matching placebo 40 mg(120 cases,placebo group).Moreover,all patients were orally administered aspirin enteric-coated tablets 100 mg,once a day fo r 12 weeks.The primary outcome was the Barthel Index(Bl).The secondary outcomes included the control rate of blood pressure and National Institutes of Health Stroke Scale(NIHSS)scores.The incidence and severity of adverse events(AEs)were calculated and assessed.Results:The Bl relative independence rates,the clinical recovery rates of NIHSS,and the total effective rates of NIHSS in the GTC and EGB groups were significantly higher than the placebo group at 12 weeks after treatment(P<0.05),and no statistical significance was found between the GTC and EGB groups(P>0.05).The control rate of blood pressure in the GTC group was significantly higher than the EGB and placebo groups at 12,18 and 24 weeks after treatment(P<0.01).There were no statistically significant differences in the incidences of AEs,adverse drug reactions,or serious AEs among the 3 groups(P>0.05).Conclusion:GTC exhibited significant efficacy in improving patients'quality of life as well as neurological function and controlling hypertension.     

抗震救灾中的传染病防治工作原则

人类的历史教训证明,包括大地震在内的严重自然灾害,对地域生态环境和人类居住条件造成极大的破坏,对灾区人员的健康造成沉重的打击.在这种情况下,发生重大传染病流行的风险将会显著增加.汶川大地震发生后,搜寻生还者,抢救伤病员是抗震救灾第一阶段的重点.     

A Bibliometrics Analysis on Academic Influence of Chinese Journal of Integrated Traditional and Western Medicine

Objective:To illustrate the academic influence of Chinese Journal of Integrated Traditional and Western medicine,and provide suggestions for further development of the Journal.Methods:Taking the China National Knowledge Infrastructure(CNKI)database as main source and the Chinese Science Citation Database(CSCD)as reference,the researchers retrieved the related data of the Journal such as its publication quantity,citations,fund projects,authors,institutions and regions from 1981 to 2018,analyzed these data by means of bibliometrics and information visualization with EXCEL,SPSS,VISIO,MATLAB and other softwares.Results:Through the analysis of the main indicators,the relevant indicators of the Journal’s academic influence revealed the developing trend of the Journal.Cardiovascular and cerebrovascular diseases,endocrine,digestive system,pharmacological research of Chinese medicine and gynecology,as the hot topics in the discipline and academic,were clarified.Conclusions:All indicators show that the Journal is a high-quality journal reflecting the excellent achievements in the field of integrated Chinese and Western medicine in China.Through further analysis of relevant indicators,the authors put forward some specific suggestions on how to run the Journal well.     

Bloodletting Puncture at Hand Twelve Jing-Well Points Relieves Brain Edema after Severe Traumatic Brain Injury in Rats via Inhibiting MAPK Signaling Pathway

Objective:To investigate whether blood-brain barrier(BBB)served a key role in the edema-relief effect of bloodletting puncture at hand twelve Jing-well points(HTWP)in traumatic brain injury(TBI)and the potential molecular signaling pathways.Methods:Adult male Sprague-Dawley rats were assigned to the shamoperated(sham),TBI,and bloodletting puncture(bloodletting)groups(n=24 per group)using a randomized number table.The TBI model rats were induced by cortical contusion and then bloodletting puncture were performed at HTWP twice a day for 2 days.The neurological function and cerebral edema were evaluated by modified neurological severity score(mNSS),cerebral water content,magnetic resonance imaging and hematoxylin and eosin staining.Cerebral blood flow was measured by laser speckles.The protein levels of aquaporin 4(AQP4),matrix metalloproteinases 9(MMP9)and mitogen-activated protein kinase pathway(MAPK)signaling were detected by immunofluorescence staining and Western blot.Results:Compared with TBI group,bloodletting puncture improved neurological function at 24 and 48 h,alleviated cerebral edema at 48 h,and reduced the permeability of BBB induced by TBI(all P<0.05).The AQP4 and MMP9 which would disrupt the integrity of BBB were downregulated by bloodletting puncture(P<0.05 or P<0.01).In addition,the extracellular signal-regulated kinase(ERK)and p38 signaling pathways were inhibited by bloodletting puncture(P<0.05).Conclusions:Bloodletting puncture at HTWP might play a significant role in protecting BBB through regulating the expressions of MMP9 and AQP4 as well as corresponding regulatory upstream ERK and p38 signaling pathways.Therefore,bloodletting puncture at HTWP may be a promising therapeutic strategy for TBI-induced cerebral edema.     

考试制度管理与改革之我见

分析目前考试制度存在的主要问题有命题、复习题、补考制度等方面的弊端,提出考试制度的改革要在加强"三风"建设、做好试题的编审工作、建立完善的考试管理制度、严肃补考纪律等方面下工夫,让严肃的考风带动良好的学风,从而提高教学质量.     

国际心肺移植新进展——2006年第26届国际心肺移植协会年会报道

2006年4月5日至4月8日第26届国际心肺移植协会(ISHLT)年会在西班牙马德里隆重召开,来自全世界从事心肺移植的专家,包括心外科、胸外科、心内科、呼吸科、麻醉科、ICU、病理科、供体协调等从事基础及临床研究等相关科室的专家共2 000多人参加了此次盛会.     

Vogt-小柳-原田综合征误诊1例报告

1临床资料 患者,男,29岁.入院前10d双眼视力突然下降,伴轻微头痛,曾就诊于其他医院,经眼科常规检查及眼部B超检查,诊断为原发性视网膜脱离,用药不详,因治疗效果不佳,于2002年10月18日来本院就诊.入院时自诉头痛明显,全身状况不佳,视力:右眼指数/1 m,左眼指数/1 m,双眼轻度睫状充血,角膜后可见细小点状沉着物,房水闪辉阳性,瞳孔呈药物性散大,直径5.5 mm,晶体不混浊,玻璃体可见条状混浊,眼压正常.     

格林巴利综合征伴一过性高血糖性酮症酸中毒一例

1病例患者,女,49岁。10日前出现中上腹不适,伴恶心呕吐,并开始出现尿量减少,全身浮肿,四肢无力,双手不能持物,双下肢不能站立,当时无咖啡样     

婴幼儿游泳探讨

游泳是人类生活中最自然的生理活动和本能之一。不仅人类，哺乳动物也常有游泳行为，是生活中自然形成和掌握的一种本能。我们认为人和动物一样，生来就具有适应环境的能力。很多动物，无论大小都有游泳本领，不用谁来教，在水中通过多种姿势和划水方法，他们都会把鼻子露出水面，往岸上游。可是人类这种本能后来泯灭了。我们认为社会就是大海，人生就如在大海中游泳，从小让孩子在水中学会挣扎，锻炼拼搏精神，促进胎儿到婴幼儿神经及各脏器的持续发育，使生长的过程得到进一步、更高质量的发展，这对他们一生的好处都是不可估量的。     

腹腔镜胆囊切除与传统的胆囊切除术对比临床分析

一百多年前 ,人们就开始对胆囊疾病施行开腹式胆囊切除术 (opencholecystectom y,OC) ,随着科学技术及内镜外科的发展 ,腹腔镜下胆囊切除术 (laparoscopiccholecystectom y,L C)的开展 ,意味着不仅在胆道外科其实是整个普通外科领域内发生了巨大的变化 ,它已作为一种微创外科 (m inim ally invasive surgexy,MIS)被外科界所承认。为了进一步研究此二种术式对机体的创伤反应及术后恢复情况 ,笔者自 1999年 3月～ 2 0 0 1年 4月对 12 0例行胆囊切除术的胆囊良性疾病患者进行对比研究。1　临床资料1.1　一般资料　选择良性胆囊疾病需择期行…     

腹腔镜胆囊切除术与开腹胆囊切除术的比较

目的：比较腹腔镜胆囊切除术（LC）与开腹胆囊切除术（OC）2种术式的优越性。方法：105例胆囊疾病患者分为两组,53例行LC,52例行OC,比较2种术式手术时间、术中出血量及术后抗生素应用时间、肛门排气时间、进食时间和住院时间。结果：LC组手术时间、术中出血量及术后抗生素应用时间、肛门排气时间、进食时间、住院时间等均较OC组患者减少或降低。结论：LC是一种安全可靠的手术方法,与传统的开腹手术相比具有创伤小、出血少、术野清楚、切口美观、术后恢复快、住院时间短等优点,将成为胆囊切除术的首选术式。     

腹腔镜胆囊切除术和开腹胆囊切除术后并发症 发生率的对比

目的 评价胆囊结石患者救治中施以开腹胆囊切除术或者腹腔镜胆囊切除术的临床意义.方法 选取胆囊结石患者118例,将其分为两组,其中常规组58例,选择开腹胆囊切除术对其施以治疗;治疗组60例,选择腹腔镜胆囊切除术对其施以治疗,观察两组手术指征和预后情况.结果 评定疗效,发现治疗组术后排气时长以及住院时长、出血量等指标优于常规组(P<0.05);治疗组60例患者中有3例(5.00%)出现并发症,常规组58例中有17例(29.31%),差异均有统计学意义(P<0.05).结论 开腹手术以及腹腔镜手术都可以充分切除患者胆囊组织,但腹腔镜手术在创伤性、安全性等方面都表现出优势,有助于促进患者术后康复,防止出现并发症,因此建议在胆囊结石患者救治中持续应用.     

腹腔镜胆囊切除术与传统开放手术对比研究

目的旨在探讨腹腔镜胆囊切除术（LC）与传统开腹手术（OC）的临床效果与安全性。方法将104例良性胆囊疾病患者分为LC组（采取腹腔镜胆囊切除术）74例和OC组（采取传统开腹胆囊切除术）70例,观察两组患者手术及术后并发症发生情况,进行统计学比较。结果 LC组病人的手术所用时间、出血量、切口大小、肠道功能的恢复时间、术后镇痛药物使用及住院时间均少或短于OC组。LC组有1例发生切口感染,OC组5例发生切口感染,2例切口局部血肿,LC组术后并发症发生率明显低于OC组。结论 LC与OC相比较,降低了病人损伤程度、加快了术后恢复速度、减少了并发症的发生,LC是治疗良性胆囊疾病较好的手术方式,临床应该借鉴应用。     

腹腔镜与小切口胆囊切除术临床对比分析

目的:探讨腹腔镜与小切口胆囊切除术的利弊。方法:将急性结石性胆囊炎、胆囊结石、胆囊息肉患者各60例随机分为腹腔镜胆囊切除组(LC)和小切口胆囊切除组(MC),每组30例。对比分析手术切口长度、手术时间、术中出血量、住院时间、住院费用。结果:急性结石性胆囊炎患者LC与MC临床对比差异无显著性,但胆囊结石、胆囊息肉患者LC与MC临床对比差异性显著,在住院费用上两者有明显差异性。结论:两种术式各有优缺点,应根据患者具体病情及术者经验,选择适合的术式,发挥其优点,真正为患者服务。     

腹腔镜与小切口手术切除胆囊治疗胆结石的临床疗效分析

目的探讨2种治疗胆囊结石的手术方式的临床疗效。方法 174例胆囊结石患者随机分为观察组（104例）和对照组（70例）,观察组采取腹腔镜胆囊切除术,对照组采取小切口胆囊切除术。结果观察组手术切口、术中出血量、术后胃肠功能恢复、下床活动时间、住院时间较之对照组明显更佳（P〈0.05）。结论腹腔镜胆囊切除术临床疗效更好。     

腹腔镜下胆囊切除术与传统开腹胆囊切除术的临床疗效对比

目的对比腹腔镜下胆囊切除术与传统开腹胆囊切除术的临床疗效。方法选取210例胆囊切除术患者,随机分为观察组和对照组,每组105例。观察组接受腹腔镜下胆囊切除术,对照组接受传统开腹胆囊切除术。比较两组患者手术疗效及并发症发生情况。结果观察组术中术后情况均显著优于对照组(P0.05),观察组并发症发生率为9.52%,明显低于对照组的18.10%(P0.05)。结论腹腔镜下胆囊切除术与传统开腹胆囊切除术相比,手术疗效更好,并发症更少,患者负重更轻,有利于早日康复。     

腹腔镜胆囊切除术与传统胆囊切除术的临床比较

目的：对腹腔镜胆囊切除术与传统胆囊切除术的疗效进行比较。方法：将1426例具有手术指征需行胆囊切除的胆囊良性疾病患者随机分为LC组和OC组，对术中、术后情况进行比较。结果：LC组手术时间、失血量、切口长度、肛门排气时间和术后住院天数均显著少于OC组（P〈0.05）。结论：腹腔镜胆囊切除术可减少对机体的创伤，有利于术后的恢复，但要注意避免相关并发症。     

Spontaneous cholecystectomy

A young female, who presented with acute appendicitis and peritonitis, is described. Following laparotomy she developed a series of intraperitoneal abscesses. After drainage of a subphrenic abscess a necrosed gallbladder was discharged several days later through the drainage wound in the abdominal wall.     

Laparoscopic cholecystectomy

In recent months, the technique of Laparoscopic Laser Cholecystectomy (LLC) was introduced at our institution. A small series is presented here involving 14 patients, seven of whom underwent LLC and seven in which a "mini-lap" cholecystectomy was performed. Symptomatic cholelithiasis was the indication for surgery in all cases, and operative cholangiograms were employed in 12 patients. Comparisons are made regarding length of hospitalization, recovery time and operative time. An improved recovery period is indeed demonstrated with LLC allowing return to normal activities and employment much sooner than with an open cholecystectomy. We suggest that, though some prudence and caution is advised, this appears to be a safe and feasible adjunct in the treatment of cholelithiasis.