应用微波热凝技术治疗口腔良性肿瘤的临床观察

目的:观察微波热凝技术治疗口腔良性肿瘤的临床效果。方法:应用微波热凝技术治疗口腔良性肿瘤161例,其中粘液腺囊肿63例,血管瘤47例,牙龈瘤2 9例,乳头状瘤2 2例。治疗1～6个月后,观察临床疗效。结果:本组病例随访1个月,粘液腺囊肿复发2例,经再次微波热凝治疗,瘤体消失;2例血管瘤10d后进行第2次治疗,瘤体完全消失。6个月后复查,全部病例无复发。结论:微波热凝治疗口腔良性肿瘤临床效果满意。     

癌前病变口腔上皮中细胞粘附分子CD44v3和CD44v6表？…

目的 研究细胞粘附分子ＣＤ４４ｖ３和ＣＤ４４ｖ６在口腔癌前病变中的表达特点及其与癌变的关系。方法 用ＳＰ免疫组织化学染色法检查８５例正常、单纯及异常增生的口腔上皮和口腔鳞癌中ＣＤ４４ｖ３和ＣＤ４４ｖ６的表达。结果 正常及单纯增生口腔上皮细胞膜有ＣＤ４４３和ｖ６的强表达，上皮染成网状。上皮轻度异常增生变化不明显。随上皮守生程度加重，上皮深层细胞出现ＣＤ４４ｖ３和ｖ６低表达，染色变浅或无染色，１２例重     

微波热凝治疗口腔良性肿瘤的临床分析

目的　探讨微波热凝治疗口腔良性肿瘤的疗效。方法　随机选择口腔良性肿瘤患者165例,其中口腔粘液囊肿83例、血管瘤42例、乳头状瘤19例、纤维性增生14例和牙龈瘤7例,采用WB-100型微波多功能治疗机治疗,观察其疗效,并随访1~3年。结果　165例患者中144例特效,1次治疗痊愈;21例显效,2次治疗痊愈;随访无 1例复发。结论　微波热凝治疗口腔良性肿瘤疗效肯定且方便、快速和安全。     

微波热凝治疗口腔扁平苔藓近期临床研究

目的：观察微波热凝治疗口腔扁平苔藓近期临床效果。方法：应用微波治疗口腔扁平苔藓（OLP）27例。并追踪观察临床效果。结果：口腔平苔藓经微波热凝治疗。痊愈18例，有效7例，无效2例。结论：微波热凝治疗口腔扁平苔藓近期临床效果满意。     

微波热凝在口腔颌面外科的应用体会

微波热凝在口腔颌面外科的应用体会湖北医科大学口腔医学院（４７００７０）赵吉宏陈明芝邓国秀近年来，微波加热已被医学界广泛应用，并不断有取得满意效果的报道［１－４］。我科自１９９３年６月至１９９６年６月用微波加热治疗口腔颌面外科常见病１７４例，报告如下。...     

微型接骨板在颌面部骨折治疗中的应用

目的 观察微型接骨板治疗颌面部骨折的效果。方法 应用微型接骨板内固定治疗颌面部骨折４５例，对术后伤口愈合情况、咬合关系、张口度、张口型、体重等进行观察。结果 ４２伤口Ⅰ期愈合、咬合关系良好４４例，术后６个月张口度均在３．０ｃｍ以上，张口型无明显偏斜，体重无明显和田结论微型接骨板内固定是治疗颌面部骨折的一种较好方法，有利于伤口愈合和咀嚼功能的早日恢复。     

复合树脂牙周夹板的临床疗效评价

目的 总结应用复合树脂牙周夹板固定松动牙的临床疗效。方法 采用不锈钢丝复合树脂制成牙周夹板。固定松动牙共１６５例，结扎固定后１个月复查以后每隔３个月或半年复查，临床观察结扎固定后的临床症状，牙松动度，牙周袋情况及咀嚼功能。摄Ｘ线片，观察牙槽骨情况而判断效果。结果 效果满意，临时性夹板成功率达１００％，半永久性９８．６％，永久性９６．８％。结论 复合树脂牙周夹板固定松动牙是治疗牙周病的方法之一，操作简单，效果较好的实用技术，值得推广。     

微波治疗复发性口疮的临床疗效

微波治疗复发性口疮的临床疗效湖北医科大学口腔医学院（４３００７０）周刚陈汉正熊金兰作者对１１８例复发性口疮患者进行微波治疗，并对治疗效果作了临床观察。现报告如下。材料和方法１．病例选择：复发性口疮患者１１８例，男性４９例，女性６９列，年龄６～６７岁，...     

微波治疗口腔颌面部血管瘤

目的 研究用微波治疗口腔颌面部不同类型、不同部位的血管瘤，探讨其治疗方法及原理，评价其治疗效果。方法 选择不同类型、不同部位的血管瘤３６例，用微波多功能治疗机针型辐射器直接刺入瘤体，分点热凝治疗。结果 ２５例经１次治疗痊愈，６例２次治疗痊愈，５例经３次以上治疗痊愈，无１例失败。结论采用微波治疗血管具有方法简单、创伤轻、疗效可靠、避免了局部组织缺损和畸形等优点。     

口腔扁平苔藓中药治疗的临床观察

把６２例口腔扁平苔藓患者随机分为二组，一组服用自制的中药，另一组服用磷酸氯喹，用药２－３月后观察临床疗效，结果发现中药组的治疗效果优于磷酸氯喹组，该中药是一种更为有效地治疗口腔扁平苔藓的方法。     

Histogenesis of Abrikossoff tumour of the oral cavity

Abstract: Background: Abrikossoff or granular cell tumour (GCT) is a relatively rare neoplasia, benign in most of the cases. It may occur in any part of the human body, but it has an oral location in 70% of the cases. Its origin has been discussed for decades, and it is not yet definitively determined. Immunohistochemical techniques suggest its origin in the Schwann cells, while more recent studies with new markers indicate an origin related to neuroendocrine cells. Objective: Contribute to the clarification of histogenesis of oral Abrikossoff tumour studying immunohistochemical marking of 11 oral Brazilian cases. Materials and methods: Samples of tissues from the oral mucosa, tongue and lips placed in paraffin blocks, from eleven patients with a histopathological diagnosis of benign GCT were studied. Four different anti‐serums (S‐100, vimentin, PGP9.5 and ENE) were used for immunoperoxydase technique. Results: A clear positivity for S‐100 protein and vimentin was observed, with markers indicating origin from the Schwann cells. Less intense positivity was found in some cases, for ENE and PGP9.5, which suggests a neuroendocrine origin. Conclusions: The results obtained suggest an origin from Schwann cells, but also arise the possibility of neuroendocrine origin. New methods and more specific immunohistochemical markers are needed to elucidate the origin of the Abrikossoff tumour.     

Nerve sheath myxoma of the tongue in a child

Nerve sheath myxoma (NSM) is a benign peripheral nervous system tumour that rarely occurs in the oral cavity. Among 17 cases of oral NSM described in the literature (average patient age 33 years), only two, including the present case, have been reported in children. The present case occurring in an 8-year-old boy was therefore extremely rare. Histopathologically, the tumour was found as multinodules under the mucosal epithelium, and was composed of spindle- or stellate-shaped cells with a myxoid background that stained with alcian blue and toluidine blue. Immunohistochemically, the tumour cells were strongly positive for S-100 beta protein and neuron-specific enolase. These results suggested that the tumour originated from Schwann cells.     

Intraoral perineurioma: report of a case with a review of the literature

Perineurioma is a rare benign peripheral nerve sheath tumour that occurs as an intraneural or extraneural form. To the best of our knowledge, this is the second reported case of an intraoral submucosal extraneural perineurioma. The tumour was symptomless, measured 2 cm in diameter and occurred in the nasolabial fold of a 46-year-old black female. Awareness of the occurrence of this neoplasm in the oral cavity is important to promote detection and differentiation from other benign spindle tumours, which occur intraorally. All reported cases of perineurioma have been benign and cure is effected by localized surgical excision.     

Benign Fibrous Histiocytoma: A Rare Case Report and Literature Review

Fibrous histiocytoma is a benign soft tissue tumour that may present as a fibrous mass anywhere in the human body. The involvement of the oral cavity is extremely rare and very few cases have been reported in literature till date. We here report a case of benign fibrous histiocytoma localized in the oral cavity. The clinical and histological features of the lesion are discussed precisely in the light of a literature review of this pathology in oral cavity.     

口腔颌面部病变组织中人乳头瘤病毒DNA的检测

为探讨人乳头瘤病毒（ＨＰＶ）和口腔颌面部肿瘤以及某些口腔粘膜病的关系，应用聚合酶链反应技术（ＰＣＲ）检测４型人乳头瘤病毒６，１１，１６，１８型ＤＮＡ．结果：４５例口腔颌面部良性病变和恶性肿瘤患者，４８份组织标本中的人乳头瘤病毒ＤＮＡ（ＨＰＶ－ＤＮＡ），总阳性率达７５．６％（３４／４５）．其中恶性肿瘤ＨＰＶ－ＤＮＡ阳性率为７６．９（２０／２６）．良性病变ＨＰＶ－ＤＮＡ阳性率为７３．７％（１４／１９）．恶性肿瘤和良性病变２组间ＨＰＶ－ＤＮＡ的型别有显著的差异，恶性肿瘤以ＨＰＶ１６和ＨＰＶ１８型为主，良性病变以ＨＰＶ１８和ＨＰＶ６为主．非肿瘤对照组共３０人ＨＰＶ－ＤＮＡ阳性率为１０％，均为ＨＰＶ１８型．ＨＰＶ１８在口腔颌面部恶性肿瘤和良性病变组织中阳性率均较高，但两者间无统计学差异     

吸烟和非吸烟口腔良恶性肿瘤组织P16蛋白的表达

目的 研究吸烟与口腔肿瘤组织中P16蛋白表达的关系，评价吸烟的危害性。方法 选取在我科住院的22例吸烟和32例非吸烟口腔良恶性肿瘤患者的手术切除标本，其中恶性肿瘤22例，良性肿瘤19例，正常组织13例。应用免疫组化技术S-P法结合高温高压组织抗原修复法，对P基因的蛋白表达进行检测，按组织病理类型进行分析。试验所得数据均由SAS软件进行统计检验。结果 吸烟组P16阳性表达率为54．55％，非吸烟组68．75％，两组统计学比较无显著性差异（P〉0．05）。不论吸烟与否，恶性肿瘤的P16阳性表达均低于良性肿瘤和正常组织，差异显著（P〈0．05）。结论 在本试验条件下，P16蛋白表达与吸烟无明显关系，P16蛋白表达缺失与口腔恶性肿瘤的发生有一定关系。     

成釉细胞瘤中Cyclin D1和CDK4表达的定量分析

目的 检测成釉细胞瘤中Cyclin D1和CDK4的表达,探讨其在成釉细胞瘤中的作用及意义。方法 选取52例成釉细胞瘤,其中良性35例,恶性17例,另取10例正常口腔黏膜作对照研究。应用免疫组化SP方法和原位杂交技术检测52例成釉细胞瘤和10例对照的正常口腔黏膜Cyclin D1蛋白及其mRNA和CDK4蛋白的表达。结果 良性和恶性成釉细胞中Cyclin D1蛋白及其mRNA的表达均显著高于对照的口腔黏膜(p<0/01)。CDK4的表达在良性、恶性和对照的口腔黏膜各组之间均具有显著性差异(p<0.01)。复发组CDK4的阳性细胞率(76.26±20.36)显著高于未复发组(65.45±17.41)(p<0.01)。在性别、年龄、发病部位、瘤体大小等方面Cyclin D1和CDK4表达均无显著性差异(p>0.05)。Cyclin D1蛋白及其mRNA的表达呈显著的正相关关系(p<0.01)。结论 Cyclin D1和CDK4参与成釉细胞瘤的发生和发展,CDK4可作为判断预后的参考指标。     

吸烟致口腔癌发生分子机制的研究

目的：研究吸烟对口腔黏膜细胞的遗传毒性，分析与口腔癌发生的关系。方法：采用单细胞凝胶电泳技术，检测24例吸烟者和17例非吸烟者（其中口腔恶性肿瘤12例，良性肿瘤19例，10例健康者）口腔黏膜脱落上皮细胞DNA损伤，按组织病理类型进行分析，观察指标为彗星尾长和彗星率。试验所得数据由SPSS、SAS软件进行统计检验和分析。结果-恶性肿瘤患者的彗星尾长和彗星率均明显高于良性肿瘤患者和健康人，有显著性差异（P〈0．01），良性肿瘤患者与健康者的彗星试验结果无显著差异（P〉0．05），吸烟者的彗星尾长和彗星率均明显高于非吸烟者（P〈0．01）。结论：吸烟可导致口腔黏膜细胞DNA损伤，随肿瘤组织病变程度的加重，DNA损伤程度亦加重。组织细胞DNA损伤与口腔恶性肿瘤的发生密切相关。     

Cysticercosis of the oral cavity: report of five cases and a review of literature

This paper reports on five cases of cysticercosis of tongue and buccal mucosa, diagnosed on fine-needle aspiration cytology (FNAC), affecting child patients who presented between January 1994 and October 1997. Four cases presented with gradually increasing nodular swelling of the dorsum of tongue and in the fifth case the swelling was situated on the buccal mucosa of the left side. A clinical diagnosis of cysticercosis was not entertained in any of these patients, who each presented with a solitary lesion; instead, it was considered to be a benign cyst or benign tumour of salivary gland or mesenchymal tissue, before FNAC diagnosis. These lesions of the oral cavity may present first to a dentist and, in endemic areas, cysticercosis should be included in the differential diagnosis of solitary nodular lesions of the oral cavity, particularly in young individuals.