肾嗜酸细胞腺瘤临床病理学分析

目的探讨肾嗜酸细胞腺瘤的临床病理特征和鉴别诊断。方法分析8例肾嗜酸细胞腺瘤临床资料及组织病理学和免疫表型特点,按WHO(2004)肾细胞肿瘤分类标准重新阅片分类。结果CT增强扫描后肿瘤密度均匀一致,瘤体中央可见星状低密度区是该瘤的主要特征。病理组织学:肉眼观察肿瘤质均,无坏死、呈棕红色,部分肿瘤有中心瘢痕;光镜下胞质强嗜酸性,粗颗粒,巢状或实片状排列,无坏死,无核分裂象或核分裂象罕见;免疫组化:CK8阳性,vim-entin阴性。结论肾嗜酸细胞腺瘤是一种肾脏良性肿瘤,CT影像特征有助于术前诊断。根据其组织学及免疫组化标记,可与胞质嗜酸性肾癌鉴别。     

鼻腔鼻窦型血管外皮瘤样肿瘤2例及文献复习

目的探讨鼻腔鼻窦型血管外皮瘤样肿瘤的临床病理特点和鉴别诊断。方法报道2例鼻腔鼻窦型血管外皮瘤样肿瘤并进行免疫组化染色及文献复习。结果 2例患者男女各1例,鼻塞、鼻出血1个月。大体均为灰红色肿物。镜下2例组织学改变基本一致。肿瘤表面被覆较完整的假复层纤毛柱状上皮。瘤细胞呈片状、短束状排列。肿瘤细胞异型性不明显,呈短梭形或卵圆形,胞质较丰富,嗜酸性,部分区域胞质透亮,细胞边界清楚。瘤组织内血管丰富,部分区域可见"鹿角"样血管。瘤细胞呈vimentin、actin弥漫阳性表达。2例均诊断为鼻腔鼻窦型血管外皮瘤样肿瘤。结论鼻腔鼻窦型血管外皮瘤样肿瘤是一种发生在鼻腔鼻窦部位罕见的血管周细胞肿瘤。临床上主要采用根治切除术。本瘤的生物学行为大多属于良性。     

针吸细胞学在儿童神经母细胞瘤诊断中的价值

目的探讨针吸细胞学(fine needle aspiration cytology,FNAC)检查在神经母细胞瘤(neuroblastoma,NB)细胞病理学诊断中的应用价值。方法应用FNAC法结合组织病理学和免疫组化法对11例NB的细胞学和组织学特征进行对照分析。结果 11例NB细胞学特征表现为瘤细胞大小不一,散在的瘤细胞中常见细胞成团现象,胞核为圆形或椭圆形,核染色质呈粗颗粒状,核仁清晰,1~4个不等,以单个核为主,亦可见双核及多核瘤细胞,部分双核瘤细胞呈"人字形",胞质较丰富,淡蓝色,胞质内可见粉红色细小颗粒。部分区域可见瘤细胞聚集呈"菊花团"状,瘤细胞间常见嗜酸性粉红色丝状纤维物。结论 FNAC作为一种简便、快速且相对微创的病理学检查方法,对大多数神经母细胞可进行准确诊断,为临床治疗提供依据。     

胸部SMARCA4缺失肿瘤4例临床病理分析

目的 探讨胸部SMARCA4缺失肿瘤的临床病理学特征。方法 采用免疫组化EnVision两步法对4例胸部SMARCA4缺失肿瘤进行检测，并复习相关文献。结果 4例胸部SMARCA4缺失肿瘤包括1例胸部SMARCA4缺失型未分化肿瘤(thoracic SMARCA4-deficient undifferentiated tumor, SMARCA4-UT)和3例SMARCA4缺失性非小细胞肺癌(SMARCA4-deficient non-small cell lung carcinoma, SMARCA4-dNSCLC)。4例均为男性，年龄54～81岁，平均67.5岁。镜下SMARCA4-UT细胞弥漫片状分布，黏附性差，瘤细胞体积大，圆形至上皮样；SMARCA4-dNSCLC细胞呈实性巢、片状或腺泡状排列，瘤细胞较大，边界清楚，胞质呈完全透明状至淡染嗜酸性。免疫表型：4例SMARCA4/BRG1均阴性，SMARCB1/INI1均阳性，其中SMARCA4-UT中CKpan个别细胞阳性，CD34、SOX2和SALL4均阳性，Ki-67增殖指数为90%。3例SMARCA4-dNSCLC中CKp...     

鼻腔鼻窦型血管外皮瘤临床病理分析

目的探讨鼻腔鼻窦型血管外皮瘤的临床病理学特征及诊断和鉴别诊断及其组织发生。方法结合其临床和影像学特点,应用HE、嗜银网状纤维染色、免疫组织化学和电镜对6例鼻腔鼻窦型血管外皮瘤的病理改变进行了分析,并对其中5例进行了随访。结果男性4例,女性2例,年龄56—71岁,平均60．5岁;肿瘤均位于右鼻腔,分别为鼻中隔1例、中鼻道1例、右总道1例、鼻腔＋筛窦2例、右眼球＋筛窦＋左右额窦1例,临床上表现为鼻塞、鼻出血、鼻腔分泌物增多及眼球胀痛、视力减退、流泪、头痛等症状。巨检：病变呈息肉样2例、呈棕色光滑肿块3例、呈灰白碎组织1例。镜下观察呈弥漫分布的短梭形细胞,规则,核分裂象少见,胞质透明或嗜酸性,血管丰富,薄壁,并可见管壁玻璃样变,鹿角状血管少见,瘤细胞多以单相排列,也可呈束状、席纹状、环状及编织状。免疫组织化学检测显示瘤细胞波形蛋白6／6阳性、平滑肌肌动蛋白5／6阳性和CD34 3／6阳性,超微结构显示瘤细胞胞质内有肌动蛋白丝,细胞间有未发育完全的连接结构。随访5例,2例复发。结论鼻腔鼻窦型血管外皮瘤是一种真正起源自血管外皮细胞,具有特殊临床病理特征、少见的中间型或低度恶性肿瘤,需结合肿瘤的组织形态和免疫组织化学特点做出诊断和鉴别诊断。     

4例腺泡状软组织肉瘤临床病理分析及文献复习

目的：探讨腺泡状软组织肉瘤（alveolar soft-part sarcoma,ASPS）的临床病理学特征及其鉴别诊断。方法：对4例ASPS的临床资料进行回顾性分析,对标本进行组织病理学观察及免疫组织化学（免疫组化）研究。结果：患者3例为男性,年龄分别为30,25,27岁;1例为女性,34岁。发病部位4例均位于下肢深部软组织内。镜下肿瘤细胞排列成腺泡状或实性,细胞巢间可见窦状血管分隔,肿瘤细胞胞质丰富嗜酸,胞质内可见棒状结晶体。免疫组化：4例均TFE3阳性,3例MyoD1胞质阳性。1例患者随访15年后复发伴肺转移死亡,3例患者随访6个月无瘤存活。结论：ASPS是一种罕见的恶性肿瘤,青少年多见,结合临床、病理学特征及免疫组化,可做出正确诊断。鉴别诊断需除外腺泡状横纹肌肉瘤等血窦丰富的肿瘤,TFE3是该肿瘤的特异性标志物。     

脊索肿瘤48例的临床病理学分析

目的探讨不同类型脊索肿瘤的临床病理特征及其诊断、鉴别诊断。方法收集2008—2019年间上海交通大学附属第六人民医院病理科诊断的48例脊索肿瘤临床、影像及病理资料,免疫组织化学做广谱细胞角蛋白(CKpan)、S-100蛋白、波形蛋白、Brachyury和INI1检测,结合第5版WHO骨和软组织肿瘤分类新标准,分析各型脊索肿瘤的病理鉴别诊断和生物学行为的差异。结果4例良性脊索细胞瘤,均限于椎体内,镜下为骨小梁间片状分布的空泡状脂肪样细胞,边界清楚,胞质透明,细胞核中位或偏位,无异型,未见核分裂象;无细胞外黏液基质,缺乏分叶状结构。2例差分化亚型,年龄分别为12岁和21岁,均位于颈椎;肿瘤细胞呈片状分布,无明显的分叶结构,胞质嗜酸性,部分细胞呈横纹肌样,偶见小的空泡状细胞。核圆形或卵圆形,有中度异型,可见核分裂象。局灶区域见细胞外黏液。40例经典型脊索瘤,影像学均呈溶骨性骨质破坏,并累及骨旁软组织;有分叶结构,丰富的黏液样基质,片状或条索状排列的上皮样肿瘤细胞,胞质呈空泡状或嗜酸性;核有异型和核分裂;侵及周围软组织。2例中轴骨外脊索瘤,镜下结构类似经典型脊索瘤。48例全部表达CKpan,45例表达Brachyury,2例差分化亚型INI1/SMARCB1表达缺失。结论脊索肿瘤包括良性的脊索细胞瘤和恶性的脊索瘤两大类,脊索瘤有经典型、去分化、差分化和中轴骨外4种亚型,软骨样脊索瘤不是独立的组织学亚型。各型脊索瘤有独特的临床病理特征。Brachyury对各型脊索肿瘤的诊断有高度特异度和灵敏度。好发于儿童和青少年的差分化脊索瘤形态特殊,需Brachyury和INI1/SMARCB1联合检测进行鉴别诊断。     

肾脏上皮样型血管平滑肌脂肪瘤临床病理分析

目的 探讨肾脏上皮样型血管平滑肌脂肪瘤(EAML)的临床病理特点及诊断与鉴别诊断.方法 通过对3例EAML临床病理学观察与免疫组化标记及复习有关文献,讨论其组织学特征及临床生物学行为.结果 3例年龄分别为28、40和32岁,均有腰痛病史,其中1例伴有肉眼血尿,均无结节硬化症.眼观:肿瘤位于肾脏,直径大小分别为6 cm、8 cm和3 cm.3例境界清楚,例2伴囊性变.肿瘤无包膜,2例出血、坏死明显,质脆或韧.镜检:瘤细胞体积大或巨大,呈多边形,胞质丰富,嗜酸性或空泡状,核仁明显,可见核内包涵体,多核巨细胞散在其中.瘤细胞弥漫性或巢团状排列.2例瘤组织出血、坏死明显,呈浸润性边缘.3例未见典型AML图像.免疫组化染色显示瘤细胞HMB-45阳性,SMA和vimentin散在性阳性,CK、EMA和CD10均阴性.结论 EAML是一种单一方向分化的,含有大上皮样细胞的肿瘤,瘤细胞较为特异的表达HMB-45.辅以免疫组化可以与其它肾脏肿瘤相鉴别.     

21例腺泡状软组织肉瘤的临床病理分析

目的探讨腺泡状软组织肉瘤的临床病理学特征及其鉴别诊断。方法对21例ASPS的临床资料进行回顾性分析,对标本进行组织病理学观察及免疫组织化学研究。结果21例腺泡状软组织肉瘤,男性11例,女性10例,发病年龄4～56岁,平均25.9岁,发病部位主要位于下肢深部软组织内,镜下肿瘤细胞排列成腺泡状或实性,细胞巢之间可见窦状血管分隔,瘤细胞胞质内含丰富的嗜酸性颗粒。PAS染色,瘤细胞胞质内可见棒状结晶体,免疫组化:MyoD110例阳性,desmin4例阳性,S-1009例阳性,NSE11例阳性,Vim11例阳性,AE1/AE3、CK、EMA、SMA、MSA、Syn全部为阴性。结论ASPS是多见于青少年和青年的罕见肿瘤,但多数早期出现血液转移,切除后易复发,最终预后欠佳,结合临床病理学特征及免疫组化,可作出正确诊断。     

肾嫌色细胞癌和嗜酸细胞腺瘤的形态学、组织化学和免疫表型的比较研究

目的探讨肾嫌色细胞癌（ehromophobe renal cell carcinoma,CRCC）和嗜酸细胞腺瘤（oncocytoma）的临床病理学特征、诊断和鉴别诊断。方法对手术切除的13例肾嫌色细胞癌和6例肾嗜酸细胞腺瘤进行眼观、光镜和电镜观察,Hale胶体铁和免疫组化染色。结果嫌色细胞癌以实体结构为主,胞质半透明或嗜酸颗粒状,核皱缩,有核周空晕;其中6例（46％）为嫌色细胞癌嗜酸变型;电镜下见胞质内微泡和管泡状嵴线粒体;Hale胶体铁染色12／13阳性。嗜酸细胞腺瘤以巢状结构为主,胞质嗜酸颗粒状,核圆伴小核仁;1例（16．7％）出现核异型性;电镜下见胞质内层状嵴线粒体;Hale胶体铁染色阴性。免疫组化两者均表达E—cadhefin、EMA,不表达CD10、CK20、vimentin;CK7在10／13例嫌色细胞癌中呈强阳性表达,2／6例嗜酸细胞腺瘤呈灶性表达。结论肾嫌色细胞癌和嗜酸细胞腺瘤形态学各有特征,免疫表型相似,鉴别诊断基于生长方式和细胞学特征,Hale胶体铁染色和电镜检查是区分二者的有效手段。     

中枢神经系统非典型畸胎样/横纹肌样瘤临床病理及免疫表型特征

目的 探讨中枢神经系统非典型畸胎样／横纹肌样瘤的临床病理特征、诊断及鉴别诊断。方法 对2例非典型畸胎样／横纹肌样瘤应用光镜行HE、网状纤维染色及免疫组织化学染色观察,并结合文献复习。结果 非典型畸胎样／横纹肌样瘤具有特征性的横纹肌样细胞,伴有不同程度的原始神经外胚叶、上皮和间质分化。肿瘤组织富于网状纤维,免疫组织化学标记示波形蛋白、CD99、上皮细胞膜抗原、细胞角蛋白、胶质纤维酸性蛋白、S-100蛋白、神经微丝蛋白、结蛋白、平滑肌肌动蛋白阳性,突触素、肌调节蛋白、胎盘碱性磷酸酶和HMB45阴性。结论 非典型畸胎样／横纹肌样瘤是中枢神经系统一种罕见的高度恶性肿瘤,好发于儿童,偶见于成人,呈异源性组织学和免疫组织化学表型。其诊断需与脑内其他多形性肿瘤鉴别。     

Rhabdoid features in leiomyosarcoma of soft tissue: with special reference to aggressive behavior.

The presence of rhabdoid cells has been reported in various types of malignant neoplasms and has been determined to be a predictor of aggressive behavior of neoplasms regardless of tumor histogenesis. One hundred and thirteen cases of leiomyosarcoma, selected from 1800 soft tissue sarcomas, were reviewed on hematoxylin and eosin sections, and immunohistochemical staining when available, and seven cases with rhabdoid features were retrieved. Clinicopathologic differences were analyzed to compare between cases with rhabdoid features and those without rhabdoid features. In the seven cases with rhabdoid features, two were intra-abdominal, and the others arose in external soft tissues including muscle, subcutis, and cutis. Patient age ranged from 33 to 84 years, three were female, and four were male. Tumor size ranged from 3 to 22 cm. Clinical evidence showed no differences from those cases without rhabdoid features. Histologically, one of the abdominal cases was epithelioid leiomyosarcoma. Two of the 7 cases were better subclassified as pleomorphic leiomyosarcoma, in which rhabdoid cells are diffusely scattered. In cases other than those with pleomorphic leiomyosarcomas, foci of anaplastic areas were observed, and collections of rhabdoid cells were present in those areas. Immunohistochemical examination of the cases confirmed myogenic differentiation, and showed rhabdoid cells being positive for vimentin and desmin in the inclusion bodies, and diffusely so for muscle actin in the cytoplasm. After dividing all the cases of leiomyosarcoma by their location, prognostic analysis was performed. Leiomyosarcoma of external soft tissue with rhabdoid cells showed a tendency for poorer prognoses than cases without rhabdoid features. On the contrary, retroperitoneal cases did not. This study indicates that rhabdoid features are associated with aggressive biological behavior in leiomyosarcoma of the external soft tissue.     

June 2004: a male in his late 60s with recurrent extracerebral tumor

June 2004: Over the past year, this man in late-60s had complained about progressive weakness of concentration and memory disturbances, associated with word finding difficulties. MRI examination revealed an extra-axial, parasagittal tumor 3 cm in diameter located in the left frontoparietal region. Five years ago, a meningioma in the same region, with radiographic appearance comparable to the present tumor had been totally removed. The histological picture of the current tumor was dominated by sheets of large rounded pleomorphic tumor cells with abundant eosinophilic cytoplasm and eccentric nuclei (rhabdoid cells). Cytoplasmic inclusions were frequent; occasionally,multinucleatedtumorcellswereseen. Mitoticfigures were absent and the MIB was 3%. Meningothelial lobules were scarce, and regions with fibroblastic appearance were absent. There were no psammoma bodies, necrosis or brain invasion. Moderate immunoreactivity for EMA was found. Additionally, strong cytoplasmic immunoreaction for vimentin within the rhabdoid cells was observed. Review of the previous material showed small islets of rhabdoid cells. Rhabdoid meningioma is an uncommon meningioma variant. It has been suggested that rhabdoid meningiomas are highly aggressive tumors (WHO grade III)and that the rhabdoid phenotype represents a marker of malignant transformation in meningiomas. Histologically, rhabdoid meningiomas usually exhibit signs of anaplasia, a high mitotic activity, and a markedly increased MIB-1 labeling index. Extracranial metastases may occur in the course of the disease. However, not all rhabdoid tumors appear to have anaplastic features (as this case illustrates). Another interesting feature of rhabdoid meningiomas is that in a significant number of cases, the rhabdoid cells appear only at the time of recurrence. Alternatively, as seen in this case, the rhabdoid cells may be already present in the primary meningioma, but not as the predominating histological feature.     

Rhabdoid meningioma: Rapid intraoperative diagnosis on squash smears

Rhabdoid morphology in tumors refers to resemblance of the cells to rhabdomyoblasts without true skeletal muscle differentiation. The cytological features include abundant eosinophilic cytoplasm, eccentric nuclei, and intracytoplasmic hyaline inclusions. Besides the rhabdoid morphology, cytoarchitectural features of atypical meningioma (four or more mitoses per 10 high‐power fields, high cellularity, sheeting architecture, nuclear atypia, and necrosis) are seen in most cases. A case is presented here to highlight the appearance of rhabdoid cells on intraoperative squash smears, for most accurate treatment and close follow‐up, as rhabdoid morphology is related to aggressive behavior and poor outcomes. Diagn. Cytopathol. 2010;38:594–596. 2009 Wiley‐Liss, Inc.     

Adenocarcinomas of the gastrointestinal tract with prominent rhabdoid features

Rhabdoid tumor, first described in kidneys of infants and children, is an aggressive tumor that has been reported in several extrarenal locations. Gastrointestinal tumors with rhabdoid features are extremely rare. The effect of the rhabdoid phenotype on the aggressiveness of gastrointestinal tumors remains unclear. We present four cases of rhabdoid tumors of the gastrointestinal tract involving the esophagus, stomach, and small intestine and discuss the clinicopathologic, immunohistochemical, and ultrastructural features. In the four cases reported herein, the patients' ages ranged from 52 to 73 years, and tumor size ranged from 3.8 to 13 cm in greatest dimension. The noncohesive rhabdoid cells exhibited an eccentric nucleus with a paranuclear inclusion, which was shown by electron microscopic examination to be composed of intermediate filaments. On immunohistochemical staining, the tumor cells were positive for vimentin and cytokeratin. Three patients developed distant metastasis shortly after diagnosis and died of disease within 2 to 10 months after initial presentation. A retrospective review of outcomes of the current cases and previously published literature showed that 12 (75%) of the 16 patients died within 6 months of presentation. Recognition of the rhabdoid phenotype in gastrointestinal tract neoplasms is important because this feature is associated with poor prognosis and unresponsiveness to conventional therapy.     

Rhabdoid meningioma: cytopathologic findings in cerebrospinal fluid

Rhabdoid meningioma is a recently described, rare, WHO Grade III intracranial tumor with an aggressive growth pattern and increased risk of recurrence. We describe the cytopathologic findings on cerebrospinal fluid of one such case in a 26-yr-old female who underwent resection of a left temporo-parietal mass. Cerebrospinal fluid contained abundant malignant cells with a prominent "rhabdoid" phenotype, i.e., large cells, eccentric nuclei, single prominent nucleoli, and dense eosinophilic cytoplasm. Although rhabdoid meningioma has a characteristic cytomorphology, the differential diagnosis of this tumor would involve metastatic adenocarcinoma, metastatic malignant melanoma, and other tumors with "rhabdoid" features (such as an atypical teratoid/rhabdoid tumor).     

Rhabdoid tumour of the lung is a dedifferentiated phenotype of pulmonary adenocarcinoma

AIMS: Primary rhabdoid tumour of the lung is rare, and histological and biological characteristics have not been fully documented. We describe three cases of primary lung rhabdoid tumour, all associated with adenocarcinoma, and investigate the histological features and biological characteristics. METHODS AND RESULTS: Three cases were obtained from a total 902 cases of surgically removed primary lung tumours between 1986 and 1998. The rhabdoid cells were found to occupy about 50-90% of each tumour. All of the tumours had nonrhabdoid adenocarcinoma foci in the centre of the tumours. Transition between the adenocarcinomatous and rhabdoid components was demonstrated. Detailed immunohistochemical studies were carried out. The epithelial markers, cytokeratins and epithelial membrane antigen (EMA), were strongly expressed in rhabdoid and adenocarcinomatous components. Furthermore, surfactant apoprotein A was positive in both components in one case, but myoglobin, MyoD and HHF35 were not expressed. Vimentin was strongly and diffusely stained in all cases. The neuroendocrine markers, chromogranin A (all cases), neuron-specific antigen (NSE) (two cases) and CD56 (one case) were occasionally positive in only a small number of the rhabdoid tumour cells. GM-CSF was positively stained in one case, and the dedifferentiated characteristics of the rhabdoid cells was suggested. Proliferative cell nuclear antigen (PCNA) was strongly demonstrated in the rhabdoid tumour cells (all cases). To gain better understanding the highly proliferative characteristics of the tumours, p53 gene (exons 5-8) mutation was examined by DNA sequencing analysis; mutation of the p53 DNA was not detected. Overexpression of p53 protein was also not demonstrated in all cases. HPV6 was demonstrated in one case by PCR method and also non-isotopic in-situ hybridization (NISH). Two cases died in a short period of time (3 years and 4 months, respectively). CONCLUSION: The rhabdoid cells in these three cases were considered to represent the dedifferentiated components of the accompanying adenocarcinoma. Dedifferentiated characteristics (neuroendocrine markers, GM-CSF, vimentin, and the aggressive behaviour) were evident.     

The ultrastructural and immunohistochemical observations of anaplastic meningioma]

Eighteen cases of anaplastic meningioma were studied by LM, EM and immunohistochemistry for vimentin, EMA, keratin, GFAP and S-100. Microscopically, there were four histologic types, i.e. fibrosarcoma-like, angiosarcoma-like, polymorphic giant cell sarcoma-like and angiopapillary structure. By EM, four kinds of cells: undifferentiated cell, intermediate transitional cell, spindle-shaped cell, and giant cell, were found and variant transitions from undifferentiated or poorly, differentiated to meningioma cells were observed. Their ultrastructures and immunohistochemical features are similar to those of malignant mesothelioma. Since these two kinds of neoplasm showed both mesenchymal and epithelial cells in the features, the authors consider that their histogenesis may also be similar.     

Intrathoracic rhabdoid carcinoma: a clinicopathological, immunohistochemical, and ultrastructural study of 6 cases

We evaluated the clinicopathological spectrum of intrathoracic rhabdoid carcinoma, including its immunophenotype and ultrastructural features. Our series included 6 cases arising from the lung (4 cases) and the anterior mediastinum (2 cases). The patients were 4 men and 1 woman aged between 40 and 63 years (median, 53 years). Microscopically, all of the lesions were composed of loosely cohesive, large, atypical polygonal cells, with glassy cytoplasms and eccentric nuclei. Chromatin texture was finely granular or open. On immunohistochemical stain, the neoplastic cells were positive for vimentin in all cases, positive for vimentin, keratins and/or epithelial membrane antigen in all cases, and negative for other antigens. In 1 case, neoplastic cells were also positive for CD34. Electron microscopic study showed prominent perinuclear whorls of densely packed intermediate filaments or mitochondria. All patients were treated with combined chemotherapy and radiotherapy. One patient died 8 months after the diagnosis was made. Of the remaining patients, 3 are alive with evidence of disease progression, including brain metastases. We concluded that rhabdoid neoplasms arising in the thoracic cavity are aggressive tumors of epithelial lineage and should be categorized as true "rhabdoid carcinomas" instead of being ambiguously designated as "intrathoracic rhabdoid tumors" or "carcinomas with rhabdoid phenotype."     

脊索样脑膜瘤临床病理分析

目的：研究脊索样脑膜瘤的临床与病理特征,以提高其早期诊断率。方法：运用组织病理学及免疫组化标记（Ｓ－Ｐ法）对３例脊索样脑膜瘤进行临床病理学和组化（ＰＡＳ）、免疫组化（ＥＭＡ、Ｖｉｍ、Ｓ－１００、ＣＫ）及电镜观察。结果：组织学瘤细胞胞浆内外均见粘液,在粘液基质背景中有成簇或成行的类液滴样细胞,瘤组织中有典型的脑膜上皮漩涡结构,组化及免疫组化示ＰＡＳ（＋）、ＥＭＡ（＋）、Ｖｉｍ（＋）、Ｓ－１００（＋）