Vascular endothelial growth factor and basic fibroblast growth factor in exudative age-related macular degeneration and diffuse diabetic macular edema

BACKGROUND: To evaluate the concentrations of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) in neovascular or edematous retinal diseases. METHODS: In the clinical comparative interventional study, VEGF and bFGF concentrations in aqueous humor samples of 35 patients with exudative age-related macular degeneration (AMD), 21 patients with diabetic macular edema and 24 patients of a control group were measured using a solid-phase chemiluminescence immunoassay. RESULTS: Concentrations of VEGF and bFGF, respectively, were significantly higher in the diabetic group (184.7 +/- 107.0 and 5.0 +/- 10.2 pg/l) than in the AMD group (107.7 +/- 73.0 pg/l, p = 0.002; 2.2 +/- 7.4 pg/l, p = 0.002) and the control group (71.5 +/- 94.7 pg/l, p = 0.001; 0.00 pg/l, p = 0.001). The two latter groups did not vary significantly (p = 0.10). CONCLUSIONS: VEGF and bFGF are present in considerably higher concentrations in eyes with diabetic macular edema than in eyes with exudative AMD or normal eyes. The differences were more marked for VEGF than for bFGF.     

The Eger Macular Stressometer: pilot study

PURPOSE: To evaluate the sensitivity of the Eger Macular Stressometer (EMS) for early screening of age-related macular degeneration (AMD) in a clinical practice. We examined the null hypothesis that AMD eyes have EMS recovery times (RTs) that do not differ from eyes with cataract, diabetic retinopathy, or glaucoma. DESIGN: The design of this study was a nonrandomized clinical trial. METHODS: Ninety-two eyes from 92 patients with vision 20/80 or better, age 50 and older, of either gender, and any ethnic origin, were recruited into one of four groups: AMD (30 eyes), normal or mild cataract (30 eyes), diabetic retinopathy (16 eyes), and glaucoma (16 eyes). Recovery times were obtained with the EMS, according to manufacturer's instructions. RESULTS: The mean (SD) [median] RT for the AMD group was 11.8 (7.6) [9] seconds, the normal/cataract group 10.0 (4.3) [9] seconds, the diabetic retinopathy group 8.4 (3.0) [8] seconds, and glaucoma group 8.6 (2.4) [8] seconds. Recovery time did not appear to be related to group (P =.58), age (P =.50), visual acuity (P =.52), or sex (P =.23). CONCLUSIONS: We found EMS RT distributions did not differ between AMD, cataract, diabetic retinopathy, and glaucoma groups. The EMS in its current form is not a sensitive screening tool for AMD. Further testing is needed to examine EMS sensitivity with other macular diseases such as central serous choroidopathy and diabetic macular edema.     

Erythropoietin levels in aqueous humour in eyes with exudative age-related macular degeneration and diabetic retinopathy

The purpose of this study was to evaluate whether the concentration of erythropoietin as another potent ischemia-induced angiogenic factor is elevated in eyes with neovascular (age-related macular degeneration [AMD]) or oedematous (diabetic retinopathy) maculopathies. The clinical comparative study included 28 patients with diabetic macular oedema, 59 patients with exudative AMD, and 49 patients with cataract. For all patients, aqueous humour was collected during cataract surgery or during an intravitreal injection of triamcinolone acetonide. Erythropoietin levels were measured using a solid-phase chemiluminescence immunoassay. The mean concentration of erythropoietin was significantly higher in the diabetic group (60.1 +/- 46.7 mUnits/mL; P < 0.001) than in the age-related macular degeneration group (22.9 +/- 23.2 mUnits/mL) and in the control group (22.0 +/- 21.0 mUnits/mL; P < 0.001). The two latter groups did not vary significantly (P = 0.41). The results indicate that erythropoietin may be present in considerably higher concentrations in eyes with diabetic macular oedema than in eyes with exudative AMD or normal eyes.     

康柏西普对DME患者黄斑部微循环的影响

目的:观察糖尿病性黄斑水肿(DME)患者注射康柏西普前后黄斑部视网膜浅层毛细血管密度及房水因子的变化,初步探讨康柏西普对DME患者黄斑部微循环的影响.方法:前瞻性病例对照研究.收集2019-12/2020-12就诊于我院眼科的DME患者10例11眼作为DME组,收集15例无全身系统疾病和眼底疾病的白内障患者作为白内障组...     

糖尿病合并白内障患者血清及房水中铬元素含量测定及分析

目的:检测2型糖尿病合并老年性白内障患者血清及眼房水中铬元素的含量,并探讨其临床意义。方法:采用石墨炉原子吸收法测定患者血清及房水中铬的含量,试验组:糖尿病(2型)合并白内障患者19例,对照组:健康的老年性白内障患者21例。结果:试验组的血清及房水铬元素含量分别为(3.79±1.17)μg/L,(0.97±0.35)μg/L,明显低于对照组(4.50±0.92)μg/L,(1.43±0.68)μg/L,且两组比较差异均有统计学意义(t=-2.139,P<0.05;t=-2.653,P<0.05),两组血清及房水中铬元素含量无显著相关性(r=-0.142,P>0.05)。结论:铬元素在糖尿病合并老年性白内障患者的发生及发展过程中具有重要作用。     

Increased levels of vascular endothelial growth factor and interleukin-6 in the aqueous humor of diabetics with macular edema.

PURPOSE: To investigate the relationship between diabetic macular edema and the levels of vascular endothelial growth factor (VEGF) and interleukin-6 (IL-6) in aqueous humor and plasma.DESIGN: Comparative cross-sectional study. METHODS: Fifty-four eyes from 54 diabetic patients were used. The concentrations of VEGF and IL-6 in undiluted aqueous specimens (obtained from the eyes during cataract surgery) and in plasma were measured by an enzyme-linked immunosorbent assay. To assess blood-aqueous barrier function, the aqueous flare intensity was measured by a laser flare-cell meter as an estimate of the aqueous protein level. RESULTS: The aqueous levels of VEGF and IL-6 were significantly correlated with the severity of macular edema (rho = 0.628, P <.001 and rho = 0.517, P <.01, respectively), as well as with the aqueous protein concentration (rho = 0.618, P <.001 and rho = 0.588, P <.001, respectively). Aqueous levels of VEGF and IL-6 were significantly higher than their respective plasma levels (both P <.001). In addition, the aqueous level of VEGF was significantly correlated with that of IL-6 (rho = 0.537, P <.01). Furthermore, the status of the posterior vitreous significantly correlated with the severity of macular edema (rho = 0.618, P <.0001). CONCLUSIONS: These results suggest that both VEGF and IL-6 are produced together in the intraocular tissues, and are involved in the pathogenesis of macular edema.     

Eye's risk factors in age-related macular degeneration (AMD). Part I

PURPOSE: To evaluate the relationship between cataract, past cataract surgery and age-related macular degeneration (AMD). MATERIAL AND METHODS: 281 eyes with AMD diagnosed with fundus fluorescein angiography were included to the study and divided into two groups: with dry (208) and exudative (73) type of AMD. 149 eyes without AMD were controls. We performed ophthalmological examination and questionnaire. We collected data regarding past cataract surgery, exposition to the sun, using of sunglasses and other. RESULTS: Eyes with AMD were more likely to have cataract and nuclear sclerosis than controls. History of cataract surgery was significantly more frequent in group with exudative AMD compared to controls. Cataract (OR = 1.93), nuclear sclerosis (OR = 3.84) and past cataract surgery (OR = 2.32) were associated with increased risk of age-related macular degeneration in multivariate analyses adjusted for age. CONCLUSIONS: The concomitance of cataract (especially nuclear sclerosis) and age-related macular degeneration may support the theory of common pathogenesis of both pathologies. There is increased risk of exudative type of AMD in eyes after cataract surgery.     

Aqueous humor levels of vascular endothelial growth factor and pigment epithelium-derived factor in polypoidal choroidal vasculopathy and choroidal neovascularization

PURPOSE: To determine the aqueous levels of vascular endothelial growth factor (VEGF) and pigment epithelium-derived factor (PEDF) in patients with active polypoidal choroidal vasculopathy (PCV) and choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD) and pathologic myopia. DESIGN: Prospective, comparative control study. METHODS: Aqueous humors were collected from 32 eyes of 32 patients for either active PCV or CNV. Among them, 11 eyes had active and symptomatic PCV, 12 eyes had active CNV secondary to AMD, and nine eyes had active CNV of pathologic myopia. Levels of VEGF and PEDF were determined by commercially available enzyme-linked immunosorbent assay kits. A group of 10 aqueous samples from 10 patients who underwent cataract surgery without other ocular or systemic diseases comprised the controls. RESULTS: VEGF concentrations in aqueous humor were markedly increased in patients with PCV, CNV of AMD, and CNV of myopia when compared with the controls (analysis of variance [ANOVA], P < .001). VEGF levels in eyes with PCV were, however, significantly lower than those of exudative AMD (P = .045). The PEDF levels were also significantly different among the groups (ANOVA, P = .001), and we observed increased levels in PCV, CNV of AMD, and CNV of myopia. CONCLUSIONS: VEGF and PEDF factors were coexpressed and increased with positive correlation in aqueous humor of eyes with active PCV. The different levels of both factors in eyes of PCV and AMD might suggest distinct clinical entities or different angiogenesis courses between PCV and AMD.     

Frequency of cataract surgery after intravitreal injection of high-dosage triamcinolone acetonide

PURPOSE: To evaluate the frequency of cataract surgery after intravitreal injection of high-dosage triamcinolone acetonide in elderly patients. METHODS: This clinical interventional case series study included 144 phakic eyes that consecutively received an intravitreal injection of about 20 mg triamcinolone acetonide for diffuse diabetic macular edema (n=42 eyes), exudative age-related macular degeneration (n=98), and branch retinal vein occlusion (n=4). Mean age was 72.3-/+8.9 years. Mean follow-up was 11.0-/+6.8 months (median, 8.8 months; range, 3 to 35.5 months). Reinjections were carried out in 12 (8.3%) eyes. RESULTS: Cataract surgery was performed in 20 (13.9%) eyes 17.4-/+9.1 months (median, 12.7 months; range, 8.0 to 35.5 months) after the first intravitreal injection. Out of the 20 eyes undergoing cataract surgery, 19 (95%) eyes had received one intravitreal injection, and 1 (5%) eye had received two previous injections. CONCLUSIONS: In the elderly population of patients with exudative age-related macular degeneration, diffuse diabetic macular edema, or branch retinal vein occlusion, intravitreal high-dosage injection of triamcinolone acetonide leads to clinically significant cataract with eventual cataract surgery in about 15% to 20% of eyes within about 1 year after the intravitreal injection.     

Management of type 2 diabetics requiring panretinal photocoagulation and cataract surgery

PURPOSE: To evaluate the outcomes in patients with diabetic retinopathy and cataract who had panretinal photocoagulation (PRP) first and cataract surgery second in 1 eye and cataract surgery followed by PRP in the fellow eye. SETTING: Department of Ophthalmology, Saiseikai Kurihashi Hospital, Saitama, Japan. METHODS: Fifty-eight eyes of 29 patients with similar bilateral cataracts and severe nonproliferative or early proliferative diabetic retinopathy were randomly assigned for treatment with cataract surgery performed after PRP (PRP-first group) or before PRP (surgery-first group). Treatment was performed in the opposite order in the contralateral eye. The main outcome measure was best corrected visual acuity (BCVA) 12 months after surgery. The secondary outcome measures were the laser parameters, progression of retinopathy and macular edema, and aqueous flare intensity. RESULTS: The percentage of eyes with a BCVA of 20/40 or better was statistically significantly higher in the surgery-first group (96.6%) than in the PRP-first group (69.0%) (P = .012). The rate of the progression of macular edema was significantly decreased in the surgery-first group (P = .033). There was no significant difference between the 2 groups in the other outcome measures. CONCLUSION: Although the order in which PRP and cataract surgery were performed had no effect on postoperative retinopathy, the BCVA was better and the rate of the progression of macular edema was decreased in the surgery-first group.     

Phacoemulsification does not induce neovascular age-related macular degeneration

PURPOSE: To investigate whether cataract surgery by phacoemulsification induces progression of early age-related macular degeneration (AMD) to neovascular AMD. METHODS: Retrospective case-control study. Included were consecutive patients who had undergone phacoemulsification from January 2000 to February 2006 at the Recklinghausen Eye Centre, who had a preexisting diagnosis of early AMD and who were followed up for at least 1 year after surgery (n = 1152 eyes of 696 patients). The control group comprised phakic patients diagnosed with early AMD from January 2000 to February 2006, who did not undergo eye surgery and were followed up for at least 1 year (n = 334 eyes of 202 patients). RESULTS: At baseline, control eyes had significantly better visual acuity than those of patients who were going to have cataract surgery (0.30/0.35 +/- 0.34 vs. 0.40/0.49 +/- 0.34, respectively; median/mean +/- SD; P < 0.001, Mann-Whitney rank sum test). After 1 year, visual acuity in the control group was worse than in surgical eyes (0.30/0.39 +/- 0.38 vs. 0.20/0.26 +/- 0.30, respectively; median/mean +/- SD; P < 0.001, Mann-Whitney rank sum test). In the cataract surgery group, neovascular AMD developed in 28 (2.43%) of 1152 eyes in the first postoperative year. In the control group, it developed in 6 (1.74%) of 344 eyes within 1 year. There was no significant difference between the groups in the incidence of neovascular AMD (P = 0.57, odds ratio 1.30, 95% CI 0.52-3.24, logistic regression analysis, adjusted for age and baseline visual acuity). CONCLUSIONS: The results indicate that cataract surgery in eyes with early AMD is not a causative factor in neovascular AMD.     

OCT对白内障患者超声乳化术后低视力原因的分析

目的应用相干光断层扫描（OCT）检查的图像特征对白内障患者超声乳化吸除术后低视力的原因进行分析。方法对术后第1~3天矫正视力低于0.3的68例（68只眼）超声乳化术后白内障患者进行OCT检查,分析其图像特征。结果在68例患者中,年龄相关性黄斑病变19例,其中干性11例,湿性8例;糖尿病性视网膜病变15例;高度近视眼底病变14例;黄斑视网膜前膜10例;视网膜静脉阻塞4例;黄斑裂孔3例;视网膜脱离1例;正常眼底2例。结论 OCT作为一种新型的高分辨率的视网膜成像技术,对白内障患者术后低视力的原因的诊断具有重要的作用。年龄相关性黄斑病变、糖尿病性视网膜病变、高度近视眼底病变可能是白内障患者术后低视力的比较常见的原因。     

糖尿病性白内障患者血清和房水中MDA与SOD的变化

目的:观察糖尿病性白内障(diabetic cataract,DC)患者血清和房水中丙二醛(MDA)与超氧化物歧化酶(superoxide dismutase,SOD)的变化,探讨氧化应激与DC的关系。方法:分别测定68例DC患者(DC组)、62例单纯糖尿病患者(D组)、60例单纯白内障患者(C组)和同期50例非糖尿病非白内障眼科手术者(NS组)血清和房水中MDA与SOD的水平。结果:与NS组比较,D组和C组患者血清和房水中MDA水平升高,SOD水平下降(均P<0.05),但D组和C组之间差异无统计学意义;与D组或C组比较,DC组MDA升高,SOD下降更明显(均P<0.05)。Pearson相关分析显示,MDA与SOD呈负相关(r=-0.835,P<0.05);Logistic回归分析显示,MDA和SOD是DC的影响因素(均P<0.05)。结论:糖尿病性白内障患者血清和房水中MDA水平升高,SOD水平下降,氧化应激可能参与了DC的发生发展。     

Aqueous humor and plasma vascular endothelial growth factor in uveitis-associated cystoid macular edema.

PURPOSE: To determine the association between cystoid macular edema and vascular endothelial growth factor concentration in the aqueous humor and plasma of uveitis patients. METHODS: Cross-sectional study. Vascular endothelial growth factor concentrations were measured by enzyme-linked immunosorbent assay in the aqueous humor of 20 uveitis patients (9 with and 11 without cystoid macular edema), and in the plasma of 40 uveitis patients (20 with and 20 without cystoid macular edema) and 20 healthy volunteers. RESULTS: Mean aqueous humor vascular endothelial growth factor concentrations for uveitis patients with and without cystoid macular edema were 152.3 and 109.5 pg/ml, respectively, P =.044. Mean plasma vascular endothelial growth factor concentrations in uveitis patients with and without cystoid macular edema and in healthy volunteers were 32.2, 29.6, and 55.0 pg/ml, respectively. Uveitis patients had lower plasma vascular endothelial growth factor levels than did healthy volunteers, P =.0002. CONCLUSION: In uveitis patients, vascular endothelial growth factor concentration is increased in the aqueous humor of eyes with cystoid macular edema. It may be useful to investigate vascular endothelial growth factor antagonists as a treatment for uveitis-associated cystoid macular edema.     

Intravitreal bevacizumab combined with cataract surgery for treatment of exudative macular degeneration.

PURPOSE: The aim of this study was to report on the combination of an intravitreal injection of bevacizumab and cataract surgery in patients with exudative age-related macular degeneration (AMD). METHODS: The interventional case series study included 11 patients (11 eyes) who received an intravitreal injection of 1.5 mg bevacizumab as treatment of exudative AMD (n = 10) or exudative myopic macular degeneration (n = 1), combined with a routine phacoemulsification and posterior chamber lens implantation for treatment of cataract. RESULTS: Intraoperatively and during the follow-up of 150 +/- 77.5 days, there were no complications related to the intravitreal application of bevacizumab combined with cataract surgery, such as wound dehiscence and leakage, delayed wound healing, corneal edema, dislocation of the pseudophakos, rupture of the posterior lens capsule, or rhegmatogenous retinal detachment. CONCLUSIONS: The results of this pilot study suggest that from a safety point of view, intravitreal injections of bevacizumab may be combined with routine cataract surgery.     

Pathogenesis of macular edema with branch retinal vein occlusion and intraocular levels of vascular endothelial growth factor and interleukin-6

PURPOSE: To determine whether correlations between vascular endothelial growth factor (VEGF) or interleukin-6 (IL-6) contribute to the pathogenesis of macular edema in eyes of patients with branch retinal vein occlusion (BRVO). DESIGN: Retrospective case-control study. METHODS: Nineteen patients with macular edema with BRVO and seven patients with non-ischemic ocular disease (control group) were studied. The degree of retinal ischemia was evaluated in terms of the area of capillary non-perfusion, and the severity of macular edema was examined by optical coherence tomography. Aqueous humor samples were obtained at the time of combined vitrectomy and cataract surgery, and VEGF and IL-6 levels in aqueous humor and plasma were determined by enzyme-linked immunosorbent assay. RESULTS: Aqueous levels of VEGF (351 +/- 273 pg/ml) and IL-6 (7.10 +/- 6.51 pg/ml) were significantly elevated in patients with BRVO compared with the control patients (119 +/- 38.7 pg/ml and 2.27 +/- 1.11 pg/ml, respectively) (P = .0017 and P = .0052, respectively). Aqueous level of VEGF was significantly correlated with that of IL-6 (P = .0396), and aqueous levels of VEGF and IL-6 were correlated with the size of the BRVO non-perfused area (P < .0001 and P = .0331, respectively). Aqueous level of VEGF was correlated with the severity of macular edema (P = .0306). CONCLUSIONS: VEGF and IL-6 may be involved in the pathogenesis of macular edema with BRVO. The increase in these cytokines might be used as a unique index of BRVO, through which we can determine the severity of the ischemic condition as being in a quiescent state or an exacerbation of macular edema.     

Evaluation of changes of macular thickness in diabetic retinopathy after cataract surgery

Purpose

To assess the macular thickness changes after cataract surgery in diabetic patients using optical coherence tomography (OCT).

Methods

We retrospectively reviewed the records of 104 diabetic patients who underwent cataract surgery. We examined the changes of macular thickness using OCT before cataract surgery and 1 week, 1-, 2- and 6-months after surgery. The central subfield mean thickness (CSMT) was used to evaluate macular edema which was defined as an increase of CSMT (ΔCSMT) > 30% from the baseline. The association between prior laser treatment or severity of diabetic retinopathy and macular thickness were also analyzed.

Results

Macular edema occurred in 19 eyes (18%) from the diabetic group and 63% of macular edema developed at 1 month after surgery. Thirteen (68%) out of 19 eyes with macular edema showed the resolution of macular edema by 6 months after surgery without treatment. ΔCSMT of eyes without a history of laser treatment was statistically greater compared to eyes with a history of laser treatment in at 1- and 2-months after surgery, but was not different than eyes who had laser treatment at 6-months after surgery. The severity of diabetic retinopathy was not significantly correlated to macular edema, but there was statistical difference when patients who had a history of prior laser treatment were excluded.

Conclusions

The incidence of macular edema after cataract surgery in diabetic patients was 18%. Its peak incidence was at 1 month post surgery and it resolved spontaneously in 68% of patients by 6 months post surgery. Prior laser treatment might prevent postoperative macular edema until 2 months after cataract surgery in diabetic patients. However, macular edema did not affect the severity of diabetic retinopathy.     

VEGF,IL-6,leptin水平测定在2型糖尿病患者房水中的临床意义

目的:检测2型糖尿病患者眼房水中血管内皮生长因子(vascular endothelial growth factor,VEGF)、白细胞介素-6(interleukin-6,IL-6)和瘦素(leptin)的含量,并探讨其临床意义。方法:对70例70眼2型糖尿病患者房水中VEGF和IL-6的含量采用双抗体夹心酶联免疫吸附法检测,leptin含量采用放射免疫法检测。根据散瞳眼底检查和眼底荧光素血管造影检查,将实验组分为:无糖尿病性视网膜病变组22例22眼、单纯型糖尿病性视网膜病变组28例28眼、增生型糖尿病性视网膜病变组20例20眼,对照组为健康的老年性白内障患者20例20眼。结果:3组房水VEGF的含量分别为(250.32±26.77),(300.11±58.89),(496.23±91.06)ng/L,IL-6含量分别为(162.81±33.92),(256.76±64.15),(391.27±90.46)ng/L,leptin含量分别为(69.80±21.37),(155.08±32.76),(230.27±56.92)ng/L,对照组房水VEGF含量为(144.69±26.55)ng/L、IL-6含量为(86.71±22.69)ng/L,leptin含量为(43.62±20.02)ng/L,对照组与实验组比较差异均有统计学意义(F=118.62,P<0.01;F=110.53,P<0.01;F=101.22,P<0.01)。对照组、NDR,BDR与PDR组房水VEGF,IL-6,leptin含量有依次增加的趋势。房水中VEGF与IL-6,leptin含量有相关性(r=0.995,P<0.01;r=0.776,P<0.01);房水中VEGF,IL-6,leptin含量与糖尿病患者的病程及糖尿病性视网膜病变的严重程度有相关性(r=0.722,P<0.01;r=0.716,P<0.01)(r=0.869,P<0.01;r=0.865,P<0.01)(r=0.776,P<0.01;r=0.765,P<0.01)。结论:VEGF,IL-6,leptin在糖尿病性视网膜病变的形成过程中有重要作用,且VEGF与IL-6,VEGF与leptin之间有相关性。     

Macular thickness after cataract surgery in diabetic patients

PURPOSE: Macular edema after cataract surgery is the main cause of unfavorable visual outcome and more common in diabetic patients. The objective of this study was to evaluate the time course of change in macular thickness in diabetic patients, compared with that in nondiabetic patients after uneventful cataract surgery. SUBJECTS AND METHODS: We examined 36 diabetic eyes and 30 nondiabetic controls preoperatively and 1, 3, 7, 30, 90, and 180 days postoperatively, using a Retinal Thickness Analyzer (RTA). Aqueous flare intensity and visual acuity were also measured. RESULTS: Macular thickening and an increase in aqueous flare were marked in diabetic eyes and controls on the first postoperative day. In nondiabetic patients, these subtle changes improved gradually and returned to near-normal within 6 months. In diabetic patients, prolonged and progressive macular thickening was observed 6 months after surgery. Macular edema in diabetic patients had a propensity to cause poorer 6-month visual acuity. CONCLUSIONS: RTA is useful for early detection of macular edema. Using RTA, we demonstrated that cataract surgery induced subclinical macular edema even in nondiabetic subjects and that progressive macular edema might cause poor visual outcome in diabetic patients.     

高度近视并发性白内障患者房水中细胞因子的检测分析

目的　探究高度近视并发性白内障（HMC）患者白内障术前、术后房水中细胞因子的变化及其与术后并发症的关系。方法　选取2020年6月至10月在南通大学附属医院行超声乳化白内障吸除术的患者60例（65眼）为研究对象，其中HMC患者24例（27眼）为HMC组，单纯年龄相关性白内障（ARC）患者36例（38眼）为ARC组。于白内障术前和术后20 h分别抽取100 μL房水，采用Luminex液相悬浮芯片检测房水中47种细胞因子含量。术后20 h在裂隙灯显微镜下观察房水闪辉和浮游细胞情况，并与所测因子进行相关性分析。于术前及术后1周、1个月、3个月对入组患眼行OCT检查，将所测的黄斑中心凹厚度（CFT）与差异表达的细胞因子进行相关性分析。结果　术后20 h，HMC组患眼房水闪辉和浮游细胞等级分布与ARC组相比差异均有统计学意义（均为P<0.05）。术前，HMC组患眼房水中肝细胞生长因子（HGF）、白细胞介素（IL）-12(P40)、嗜酸性粒细胞趋化因子（Eotaxin）浓度均明显高于ARC组，血管内皮生长因子浓度明显低于ARC组（均为P<0.05）。术后20 h，HMC组患眼房水中14种细胞因子均比ARC组明显增高（均为P<0.05）。HMC组患眼术前CFT明显薄于ARC组（P=0.018），术后1周、1个月、3个月CFT均比术前显著增加（均为P<0.05）。相关性分析结果显示，HMC组患眼术后1个月CFT与术前房水中HGF、IL-12(P40)浓度均呈正相关，与术后20 h房水中HGF、IL-12(P40)、干扰素诱导蛋白（IP）-10浓度均呈正相关,与IL-13浓度呈负相关（均为P<0.05）。多元线性回归分析结果显示，术前房水中IL-12(P40)浓度，术后房水中IL-12(P40)、IP-10、IL-13浓度是HMC患者术后CFT的影响因素。结论　HMC患者白内障术后前房炎症反应较重，易发生黄斑水肿等术后并发症。房水中IL-12(P40)、IP-10、IL-13浓度有望成为HMC患者白内障术后黄斑水肿的预测指标和治疗靶点。