无声的世界温情的服务

一天晚上,店里来了一位“神秘”顾客,她面无表情在店里转了好几圈,谁招呼她,她都不理.“难道是来暗访的？但是怎么看也不像呀.”大家悄悄议论着.     

感冒清热颗粒的的质量标准

目的：制定感冒清热颗粒质量标准。方法：采用TLC法对方中柴胡、葛根、防风、苦地丁进行定性鉴别；采用HPLC法对颗粒中的葛根素进行含量测定。结果：本品薄层色谱特征明显，葛根素平均回收率为100．1％；RSD为0．9％（n=6）。结论：该方法简便、准确，可控制感冒清热颗粒的质量。     

平凡的岗位 默默的奉献

举世瞩目的2010上海世博会于2010年5月1日正式拉开帷幕,此次世博会历时184天,是由中国举办的首届世界博览会,参观人数创下了世博会历史上的最高纪录,同时也给世博食品安全保障提出了新的挑战和严峻的考验。     

企业的铁腕 店员的朋友

高素平,常州恒泰奥园人民大药房店长。2013年5月,她调入这个大店,前任店长因身体原因已经一个多月没来店里,接收时门店管理非常混乱,月完成率下滑到只有80%,对于一个年营业额过千万的店来说,这意味着什么？高素平开始紧锣密鼓地整顿,大到商品结构、库存控制,     

看得见的与看不见的

我有时也与一些投资公司聊天,他们一般会问三个标准问题。问题一：网上卖药对实体药店有没有影响？答：当然有影响,尤其是安全套、家用医疗器械。经过类别分析,实体店里药食同源类商品增长较快,处方药与OTC有一定增长,而安全套与器械类没有增长,保健品似乎是负增长。这显然是网上药店的冲击所致。     

你的偏头痛是怎样的

偏头痛是一种周期性发作的神经一血管功能障碍引起的头痛,常有家族史.以反复发作的一侧或两侧搏动性头痛为特征,为临床常见的特发性头痛.     

光荣的事业 无悔的选择

微笑是最美丽的表情,真诚是联系人与人之间最真挚的纽带,爱是人类最伟大的情感.作为一名药师,在与病人最真诚的交流中,给予病人的是发自内心的爱,全身心投入的爱,无私奉献的爱.我是一名药师,是一名体会着爱与被爱的幸福与温暖的药师.     

海的味道 山的味道

对于一个正宗吃货来说,"海的味道、山的味道"一定是不陌生的,读过《窗边的小豆豆》这本书的美食爱好者们印象应该更深刻。巴学园的校长要求孩子们带来的盒饭里要有海的味道和山的味道。山的味道,比如说蔬菜啦,肉啦(当然,肉并不是在山上得到的,但是大致区分一下的话,牛啊猪啊鸡啊都是生长在陆地上的,就归人"山的味道"里面);海的味道则是鱼啦,红烧海味什么的。总之,校长大人没     

崭新的起点 崭新的征程

正西方哲学家赫拉克利特说:人不能两次踏进同一条河流。对于新时代健康产业集团而言,每一天都是一个崭新的起点,对于新时代人而言,每一天都被美好明天的憧憬所振奋。新时代人在扎根现实、立足市场的同时,常怀感恩之心,常思奋起之志,以17年发展的累累硕果为崭新的起点,开辟全新的征程。今天的新时代人已经开启了健康产业发展的新时代,新时代人正准备进入与人体健康有关的更广阔的新领域,满足新时期大时代背景下社会民众的健康需求。广大新时代人在大健康产业格局远景     

光荣的事业无悔的选择

法国文学家雨果在他的诗里曾经写到:"花是尊贵的,果实是甜美的,让我们都来做叶吧,因为叶,是平凡而谦逊的."我觉得这首诗就是为我们药师写的,因为药师就像那默默奉献的绿叶,时时刻刻衬托着鲜花的娇艳.     

Efficacy of gut lavage,hemodialysis, and hemoperfusion in the therapy of paraquat or diquat intoxication

Clinical and in vitro investigations were carried out to test the efficacy of gut lavage, hemodialysis, and hemoperfusion in the treatment of poisoning with paraquat or diquat. In a patient suffering from diquat intoxication 130 times more diquat was removed by gut lavage 30 h after ingestion than was removed by complete aspiration of the gastric contents.Determination of in vitro clearances for paraquat and diquat by hemodialysis showed that, at serum concentrations of 1–2 ppm, such as are frequently encountered in poisoning in man, toxicologically relevant quantities of herbicide cannot be removed from the body. At a concentration of 20 ppm, on the other hand, hemodialysis proved to be effective, the clearance being 70 ml/min at a blood flow rate of 100 ml/min. The efficacy of hemoperfusion with coated activated charcoal was on the whole better. Especially at concentrations around 1–2 ppm, the clearance values for hemoperfusion were some 5–7 times higher than those for hemodialysis.In a patient suffering from paraquat poisoning, both hemodialysis as well as hemoperfusion were carried out. The in vitro results could be confirmed: At serum concentrations of paraquat less than 1 ppm no clearance could be obtained by hemodialysis while by hemoperfusion with activated charcoal quite high clearance values were measured and the serum level dropped down to zero.

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Zusammenfassung Klinische Untersuchungen und Laboratoriumsversuche wurden durchgeführt, um die Wirksamkeit von Darmspülung, Hämodialyse und Hämoperfusion bei Paraquat- und Deiquat-Vergiftungen zu prüfen.Bei einem Patienten wurde 30 Std nach Deiquat-Aufnahme durch Darmspülung 130mal mehr Deiquat entfernt als durch vollständige Aspiration des Mageninhaltes. In vitro-Versuche ergaben, daß bei Blutserumkonzentrationen von 1–2 ppm, die bei Vergiftungen oft gemessen werden, durch Hämodialyse keine toxikologisch relevanten Paraquat- oder Deiquat-Mengen entfernt werden können. Dagegen erwies sich die Hämodialyse bei 20 ppm und einer Blutumlaufgeschwindigkeit von 100 ml/min mit einer Clearance von 70 ml/min als wirksam. Die Hämoperfusion mit beschicheter Aktivkohle war in diesen Versuchen aber eindeutig überlegen, denn insbesondere bei Konzentrationen um 1–2 ppm waren die Clearance-Werte 5–7mal höher als bei der Hämodialyse.Die in vitro-Ergebnisse wurden bei einem Patienten mit einer Paraquat-Vergiftung bestätigt: Bei Konzentrationen unter 1 ppm war die Hämodialyse wirkungslos, während durch Hämoperfusion relativ hohe Clearance-Werte erreicht wurden, so daß der Serumspiegel rasch unter die Nachweisgrenze abfiel.

     

In vitro studies on sterically stabilized liposomes (SL) as enzyme carriers in organophosphorus (OP) antagonism

This study describes a new approach for organophosphorous (OP) antidotal treatment by encapsulating an OP hydrolyzing enzyme, OPA anhydrolase (OPAA), within sterically stabilized liposomes. The recombinant OPAA enzyme was derived from Alteromonas strain JD6. It has broad substrate specificity to a wide range of OP compounds: DFP and the nerve agents, soman and sarin. Liposomes encapsulating OPAA (SL)* were made by mechanical dispersion method. Hydrolysis of DFP by (SL)* was measured by following an increase of fluoride ion concentration using a fluoride ion selective electrode. OPAA entrapped in the carrier liposomes rapidly hydrolyze DFP, with the rate of DFP hydrolysis directly proportional to the amount of (SL)* added to the solution. Liposomal carriers containing no enzyme did not hydrolyze DFP. The reaction was linear and the rate of hydrolysis was first order in the substrate. This enzyme carrier system serves as a biodegradable protective environment for the recombinant OP-metabolizing enzyme, OPAA, resulting in prolongation of enzymatic concentration in the body. These studies suggest that the protection of OP intoxication can be strikingly enhanced by adding OPAA encapsulated within (SL)* to pralidoxime and atropine.     

Synthesis,Cytotoxicity and Antileishmanial Activity of Some N-(2-(indol-3-yl)ethyl)-7-chloroquinolin-4-amines

We report herein the condensation of 4,7-dichloroquinoline (1) with tryptamine (2) and D-tryptophan methyl ester (3) . Hydrolysis of the methyl ester adduct (5) yielded the free acid (6) . The compounds were evaluated in vitro for activity against four different species of Leishmania promastigote forms and for cytotoxic activity against Kb and Vero cells. Compound (5) showed good activity against the Leishmania species tested, while all three compounds displayed moderate activity in both Kb and Vero cells.     

Steroidal sapogenin contents in some domestic plants

In order to find out the values of the steroid resources for the future use. the compositions and contents of steroidal sapogenins from 13 domestic plants have been investigated. As a result,Dioscorea nipponica, D. quinqueloba andSmilax china were found to have large amount of diosgenin. And pennogenin inTrillium kamtschaticum andParis verticillata, yuccagenin inAllium fistulosum, hecogenin inAgave americana and neochlorogenin inSolanum nigum were appeared to be major steroidal sapogenins.     

Aquatic Insects and Trace Metals: Bioavailability,Bioaccumulation, and Toxicity

Abstract

The uptake of metals from food and water sources by insects is thought to be additive. For a given metal, the proportions taken up from water and food will depend both on the bioavailable concentration of the metal associated with each source and the mechanism and rate by which the metal enters the insect. Attempts to correlate insect trace metal concentrations with the trophic level of insects should be made with a knowledge of the feeding relationships of the individual taxa concerned. Pathways for the uptake of essential metals, such as copper and zinc, exist at the cellular level, and other nonessential metals, such as cadmium, also appear to enter via these routes. Within cells, trace metals can be bound to proteins or stored in granules. The internal distribution of metals among body tissues is very heterogeneous, and distribution patterns tend to be both metal and taxon specific. Trace metals associated with insects can be both bound on the surface of their chitinous exoskeleton and incorporated into body tissues. The quantities of trace meals accumulated by an individual reflect the net balance between the rate of metal influx from both dissolved and particulate sources and the rate of metal efflux from the organism. The toxicity of metals has been demonstrated at all levels of biological organization: cell, tissue, individual, population, and community. Much of the literature pertaining to the toxic effects of metals on aquatic insects is based on laboratory observations and, as such, it is difficult to extrapolate the data to insects in nature. The few experimental studies in nature suggest that trace metal contaminants can affect both the distribution and the abundance of aquatic insects. Insects have a largely unexploited potential as biomonitors of metal contamination in nature. A better understanding of the physico-chemical and biological mechanisms mediating trace metal bioavailability and exchange will facilitate the development of general predictive models relating trace metal concentrations in insects to those in their environment. Such models will facilitate the use of insects as contaminant biomonitors.