Antineoplastic agents. 553. The Texas grasshopper Brachystola magna

Bioassay (P388 lymphocytic leukemia cell line and human cancer cell lines) guided separation of an extract prepared from the previously chemically uninvestigated Texas grasshopper Brachystola magna led to isolation of the cancer cell growth inhibitory pancratistatin (1), narciclasine (2), and ungeremine (3). Pancratistatin (1) was first isolated from the bulbs of Hymenocallis littoralis), and the original crystal structure was deduced by X-ray analysis of a monomethyl ether derivative. In the present study pancratistatin (1) was isolated from an extract of B. magna, which led to the X-ray crystal structure of this anticancer drug. Since isoquinoline derivatives 1-3 are previously known only as constituents of amaryllidaceous plants, some of the interesting implications of their rediscovery in the grasshopper B. magna that does not appear to utilize amaryllis family plants were discussed.     

The use of traditional plant medicines for non-insulin dependent diabetes mellitus in south Texas

The use of traditional plant medicines, as well as the factors associated with their use, were documented in 662 outpatients with non-insulin dependent diabetes mellitus enrolled at six primary care clinics in South Texas. Forty-nine percent of the patients reported using alternative treatments for their diabetes, which included 61 different traditional plant medicines. The four most commonly reported were nopal (Opuntia streptacantha) or the prickly pear cactus, chaya (Cnidoscolus chayamansa), míspero (Eriobotrya japonica) or loquat, and sávila (Aloe vera). Logistic regression was used to develop a multivariate model which indicated that alternative medicine use is positively associated with age and diabetes-related ‘hassles’, and was more likely among border residents and individuals who were born in Mexico. Disease severity was not associated with the use of alternative treatments when controlling for other variables. Users of alternative treatments also appeared just as likely to adhere to orthodox biomedical treatment recommendations as non-users. While preliminary reports in the literature suggest that some of the identified plants have hypoglycaemic properties, information is limited or nonexistent for many of the other plants. Given their preponderance in this region, some of these plants should be targeted for further investigation to document their efficacy or to screen for toxicity. © 1997 John Wiley & Sons, Ltd.     

德克萨斯脊柱康复计划对腰椎术后患者的影响

〔摘 要〕 目的：探讨德克萨斯脊柱康复计划对腰椎术后患者疼痛及功能障碍恢复情况的影响。方法：选取赣州市人民 医院 2018 年 1 月至 2020 年 12 月收治的 586 例腰椎间盘突出症（LDH）患者为研究对象,随机将患者均分成对照组和观 察组,各 293 例。其中对照组患者接受常规护理干预,观察组患者接受德克萨斯脊柱康复计划。保持对患者随访 3 个月, 比较患者干预后视觉模拟评分法（VAS）、日本骨科协会评估治疗分数（JOA）、Oswestry 功能障碍指数（ODI）评分的变 化,同时比较患者生活质量变化和干预满意度。结果：干预前,两组患者 VAS、JOA、ODI 评分比较,差异无统计学意义 （P ＞ 0.05）;干预 1 周后、干预 3 个月后,观察组患者 VAS、ODI 评分均低于对照组,JOA 高于对照组,差异均具有统 计学意义（P ＜ 0.05）。干预前与干预 1 周,两组患者生活质量评分比较,差异无统计学意义（P ＞ 0.05）;干预 3 个月后, 观察组患者生活质量评分高于对照组,差异具有统计学意义（P ＜ 0.05）。结论：德克萨斯脊柱康复计划能帮助 LDH 患者 脊柱功能快速恢复,并可显著缓解患者疼痛,使患者生活质量得到提升。     

Prehistoric peyote use: alkaloid analysis and radiocarbon dating of archaeological specimens of Lophophora from Texas

Two archaeological specimens of peyote buttons, i.e. dried tops of the cactus Lophophora williamsii (Lem.) Coulter, from the collection of the Witte Museum in San Antonio, was subjected to radiocarbon dating and alkaloid analysis. The samples were presumably found in Shumla Cave No. 5 on the Rio Grande, Texas. Radiocarbon dating shows that the calibrated 14C age of the weighted mean of the two individual dated samples corresponds to the calendric time interval 3780-3660 BC (one sigma significance). Alkaloid extraction yielded approximately 2% of alkaloids. Analysis with thin-layer chromatography (TLC) and gas chromatography-mass spectrometry (GC-MS) led to the identification of mescaline in both samples. No other peyote alkaloids could be identified. The two peyote samples appear to be the oldest plant drug ever to yield a major bioactive compound upon chemical analysis. The identification of mescaline strengthens the evidence that native North Americans recognized the psychotropic properties of peyote as long as 5700 years ago.     

《针刺研究》第36卷(2011年)总目次

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S. K. Adesina, O. Idowu, A. O. Ogundaini, H. Oladimeji, T. A. Olugbade, G. O. Onawunmi and M. Pais, 'Antimicrobial constituents of the leaves of EAcalypha wilkesiana and acalypha hispida'. Phytotherapy research14(5) 2000, 371-374

The original article to which this Erratum refers was published in Phytotherapy Research 14(5) 2000, 371-374. Following publication of this paper in the August 2000 issue of Phytotherapy Research (14(5):371-374), it has come to our attention that the dates of receipt and acceptance were printed incorrectly. The corrected dates appear below. The publishers would like to apologise for any confusion caused. Received 28 August 1996 Accepted 15 June 1997     

Mr. President,

We are writing to you on purpose to explore the friendly cooperation between our two sides. You have known that an academy periodical called as World Journal of Acupuncture-Moxibustion has been sponsored by World Federation of Acupuncture-Moxibustion Societies and Institute of Acupuncture-     

Antineoplastic agents. 42. The butterfly, Prioneris thestylis.

Isoguanine (2) was found to be an antineoplastic constituent of Prioneris thestylis Dbldy. wings. Three other purine components of the butterfly wings were identified as hypoxanthine (3), uric acid (4) and xanthine (5). Isolation of urocanic acid (6) from the same wing material represented the first detection of this interesting histidine derivative in an arthropod.