Graves＇病甲状腺自身免疫性抗体的研究

利用大鼠甲状腺细胞（ＦＲＴＬ─５）培养的方法检测了２０例Ｇｒａｖｅｓ＇病患者血清甲状腺刺激性抗体（ＴＳＩ）和甲状腺生长刺激性抗体（ＴＧＩ）。ＴＳＩ活性用ＦＲＴＬ─５细胞分泌ｃＡＭＰ量测定；ＴＧＩ活性用［~３Ｈ］─胸腺嘧啶核苷（［~３Ｈ］─Ｔｄｒ）掺入ＦＲＴＬ─５细胞ＤＮＡ量测定。结果发现：２０例患者中１６例ＴＳＩ阳性，１４例ＴＧＩ阳性。比较不同的Ｇｒａｖｅｓ＇病患者血清ＴＳＩ与ＴＧＩ活性，可将ＩｇＧ分为３类：对ＦＲＴＬ─５细胞ｃＡＭＰ分泌和［~３Ｈ］─Ｔｄｒ渗入都具有较强刺激作用的ＩｇＧ（１０例）；较强刺激ｃＡＭＰ分泌，低度刺激或不刺激［~３Ｈ］─Ｔｄｒ掺入的ＩｇＧ（６例）；较强刺激［~３Ｈ］─Ｔｄｒ掺入，低度刺激或不刺激ｃＡＭＰ分泌的ＩｇＧ（４例）。表明Ｇｒａｖｅｓ＇病自身抗体是多克隆抗体，多数存在两种甲状腺刺激性抗体──ＴＳＩ和ＴＧＩ；Ｇｒａｖｅｓ＇病的不同表现形式可能与患者血清内ＴＳＩ、ＴＧＩ活性不同有关。     

固定在磁性粒子上的抗体及在放射免疫分析中的应用——IAEA研究课题进展的回顾

固定在磁性粒子上的抗体及在放射免疫分析中的应用＊——ＩＡＥＡ研究课题进展的回顾沈荣森周凤祁北京放射医学研究所北京１００８５０⒇应用固相分离技术，是放射免疫分析（ＲＩＡ）和免疫放射分析（ＩＲＭＡ）方法学发展中的重大改进。其中，研制磁性粒子固相抗体是一项...     

99Tcm-MIBI心肌断层显像用于直接PTCA及静脉溶栓治疗AMI的对比研究

目的　比较直接经皮冠状动脉腔内成形术（ 直接ＰＴＣＡ） 和静脉溶栓疗法在急性心肌梗死（ＡＭＩ） 治疗中的效果。方法　１２４ 例ＡＭＩ患者（ 直接ＰＴＣＡ组６０ 例,溶栓组６４ 例） 均于发病２ 周时和１２ 周后行９９Ｔｃｍ甲氧基异丁基异腈（ＭＩＢＩ）心肌断层显像,将左室心肌分为２０ 个节段,并对心肌摄取９９ＴｃｍＭＩＢＩ的程度进行打分,分别计算发病２ 周时心肌显像的总积分（Ｓ２ＷＳ） 、发病后１２ 周心肌显像的总积分（Ｓ１２ＷＳ）和两者相减的积分（ＳＤＳ）。直接ＰＴＣＡ组和溶栓组分别有３８ 人和３５ 人于心肌显像后行平衡法门控心室显像。结果　直接ＰＴＣＡ 组与溶栓组比较：Ｓ２ＷＳ为１８－３±６－９ 和２８－６ ±７－３（ｔ＝７－３,Ｐ＜ ０－００１）,Ｓ１２ＷＳ为１１－２ ±４－２ 和２４－４ ±６－２（ｔ＝ １１－７,Ｐ＜ ０－００１）,ＳＤＳ为７－６ ±３－２ 和４－３ ±１－１（ｔ＝ ５－４,Ｐ＜ ０－００１）。直接ＰＴＣＡ组和溶栓组入院２ 周时的左室射血分数（ＬＶＥＦ） 分别为（４１－４ ±６－５） ％ 和（３９－５ ±７－２）％ （ｔ＝ １－５ ,Ｐ＞ ０－０５）,出院１２ 周后的ＬＶＥＦ 分别为（６２－６ ±７－８）％ 和（５１－４ ±     

烟雾病的磁共振成像诊断

目的：回顾分析８例烟雾病的磁共振成像表现，探讨磁共振成像对烟雾病的诊断价值。方法：８例烟雾病中男女各４例。年龄４～４９岁，平均２０．４岁。磁共振成像应用Ｓｉｅｍｅｎｓ１．０ＴＭＲ系统和头表面线圈。均有ＳＥ序列Ｔ１ＷＩ和Ｔ２ＷＩ，７例有三维时间飞跃法磁共振血管造影（３Ｄ－ＴＯＦＭＲＡ），１例有ＤＳＡ。结果：ＳＥ序列ＭＲＩ均见丘脑－基底节区（单侧２例，双侧６例）有扩张的烟雾血管，其中以Ｔ１ＷＩ显示更为清楚直观。７例３Ｄ－ＴＯＦＭＲＡ和１例ＤＳＡ均见ＩＣＡ上端、ＭＣＡ和ＡＣＡ近端闭塞以及丘脑－基底节区的烟雾血管。这些病理血管分布侧别与ＳＥ序列磁共振成像所见一致。结论：ＳＥ序列磁共振成像和３Ｄ－ＴＯＦＭＲＡ是诊断烟雾病的有效方法。Ｔ１ＷＩ显示丘脑－基底节区烟雾血管优于Ｔ２ＷＩ。３Ｄ－ＴＯＦＭＲＡ尚适用于烟雾病血管旁路术后随诊及其高危人群普查。     

心肌肌凝蛋白轻链放射免疫分析及临床初步应用

为提供急性心肌梗塞（ＡＭＩ）早期血清学诊断法，用改进后的Ｓｃｈｏβ法提取狗肌凝蛋白轻链（ＣＭ－ＬＣ），免疫兔获得抗血清。氯胺Ｔ法标记抗原，建立血清ＣＭ－ＬＣ ＲＩＡ。结果：该方法标准曲线测量范围１－１００μｇ／Ｌ，批内、批间（ＣＶ分别是３．２％和９．１％，平均回收率９５．３％。正常人３０例血清ＣＭ－ＬＣ为３．５±１．５μｇ／Ｌ，２０例ＡＭＩ患 者血清ＣＭ＝ＬＣ为２０．２±８．６μｇ／Ｌ，两组间差异     

应用MRA 3D TOF及三维血管图像后处理技术诊断颅内小动脉瘤

目的：应用三维血管图像后处理技术，提高ＭＲＡ对颅内小动脉瘤的诊断率。材料与方法：经手术或ＤＳＡ证实的１３例颅内小动脉瘤患者在１．５ＴＳｉｇｎａＭＲ超导系统上进行２ＤＰＣ及３ＤＴＯＦ法ＭＲＡ检查。采用ＭＯＴＳＡ扫描技术，５１２×２５６ｍａｔｒｉｘ，扫描参数中加ＭＴ。并用ＩＶＩ及３ＤＮａｖｉｇａｔｏｒ软件对血管成像进行再处理。比较２ＤＰＣ图像、３ＤＴＯＦ中的原始图像、叠加图像、再投影图像及ＩＶＩ图像、３ＤＮａｖｉｇａｔｏｒ图像动脉瘤及载瘤血管的显示情况。结果：２ＤＰＣ只有２例显示了动脉瘤瘤体，３ＤＴＯＦ叠加图像中因血管重叠也只有４例能显示瘤体，再投影图像中有３例因重叠及背景因素干扰而瘤体显示不清，原始图像及血管后处理图像均较满意地显示了瘤体，ＩＶＩ及３ＤＮａｖｉｇａｔｏｒ图像对显示载瘤血管有优势。结论：三维血管后处理图像结合原始图像观察可提高ＭＲＡ对脑小动脉瘤的诊断率。     

脑血管畸形的MRI及MRA诊断

目的：研究脑动静脉畸形与海绵状血管瘤的ＭＲＩ及ＭＲＡ特征，评价不同的成像方法对脑血管畸形的诊断价值。材料与方法：对２１例脑动静脉畸形及６例海绵状血管瘤分别作了常规ＭＲ成像及ＭＲ血管成像，ＭＲＩ采用ＳＥＴ１和Ｔｕｒｂｏ ＳＥ Ｔ２加权序列，ＭＲＡ采用２Ｄ－ＦＬＡＳＨ及３Ｄ－ＦＩＳＰ序列，６例海绵状血管瘤ＭＲＡ仅使用２Ｄ－ＦＬＡＳＨ序列。所有成像以环形激化头线圈在１．０Ｔ ＭＲ仪上完成。结果：Ｔ１及Ｔ     

肝癌“双弹头”免疫导向药物的实验研究

以肝细胞癌单克隆抗体ＨＡｂ１８为载体，用葡聚糖作桥的间接交联方法和氯胺Ｔ法，同时将阿霉素和＾１３１Ｉ连接到ＨＡｂ１８上，制备出“双弹头”肝癌免疫导向药物＾１３１Ｉ－ＨＡｂ１８－ＡＤＭ。其免疫结合率为４３．５％。细胞毒实验结果显示，＾１３１Ｉ－ＨＡｂ１８－ＡＤＭ对靶肿瘤细胞ＳＭＭＣ－７７２１的杀伤效果较单独应用ＡＤＭ相同浓度的ＨＡｂ１８－ＡＤＭ和比较放射性相同的＾１３１Ｉ－ＨＡｂ１８时，有明显的增强     

对缺氧代谢敏感的鼠心肌线粒体膜^99Tc^m—MIBI特异性结合蛋白 …

探讨＾９９Ｔｃ＾ｍ－甲氧基异丁基异腈心肌线粒体非膜电位依赖性结合机制。方法分离ＳＤ大鼠心肌线粒体片段和制作心肌超薄切片。用薄层层析法（ＴＬＣ）和ＳＤＳ聚丙酰胺凝胶电泳法（ＳＤＳ－ＰＡＧＥ）分析＾９９Ｔｃ＾ｍ－ＭＩＢＩ特异性结合蛋白。采用有氧－缺氧－再给氧程序分析＾９９Ｔｃ－ＭＩＢＩ对心肌摄取和清除＾９９Ｔｃ＾ｍ－ＭＩＢＩ的影响。结果在ＴＬＣ上可见２个结合９９Ｔｃ＾ｍ－ＭＩＢＩ计数峰。其中之一Ｋｄ值     

肝癌“双弹头”免疫导向药物的实验研究

以肝细胞癌单克隆抗体ＨＡｂ１８为载体，用葡聚糖作桥的间接交联方法和氯胺Ｔ法，同时将阿霉素（ＡＤＭ）和１３１Ｉ连接到ＨＡｂ１８上，制备出“双弹头”肝癌免疫导向药物１３１Ｉ－ＨＡｂ１８－ＡＤＭ。其免疫结合率为４３．５％。细胞毒实验结果显示，１３１Ｉ－ＨＡｂ１８－ＡＤＭ对靶肿瘤细胞ＳＭＭＣ－７７２１的杀伤效果较单独应用ＡＤＭ相同浓度的ＨＡｂ１８－ＡＤＭ和比放射性相同的１３１Ｉ－ＨＡｂ１８时，有明显的增强。１３１Ｉ－ＨＡｂ１８－ＡＤＭ具有选择性高效杀伤的作用，它集中了化疗与内放射治疗的优点，互相补充，展示了肿瘤导向治疗的良好前景。     

Knee injury and Osteoarthritis Outcome Score (KOOS) - validation of a Swedish version

The Knee injury and Osteoarthritis Outcome Score (KOOS) is a self-administered instrument measuring outcome after knee injury at impairment, disability, and handicap level in five subscales. Reliability, validity, and responsiveness of a Swedish version was assessed in 142 patients who underwent arthroscopy because of injury to the menisci, anterior cruciate ligament, or cartilage of the knee. The clinimetric properties were found to be good and comparable to the American version of the KOOS. Comparison to the Short Form-36 and the Lysholm knee scoring scale revealed expected correlations and construct validity. Item by item, symptoms and functional limitations were compared between diagnostic groups. High responsiveness was found three months after arthroscopic partial meniscectomy for all subscales but Activities of Daily Living.     

Endovascular management of carotid-cavernous fistulas

Objective To investigate endovascular treatment of traumatic direct carotid-cavernous fistulas （CCF） and their complications such as pseudoaneurysms. Methods： Over a five-year period, 22 patients with traumatic direct CCFs were treated endovascularly in our institution. Thirteen patients were treated once with the result of CCF occluded, 8 twice and 1 three times. Treatment modalities included balloon occlusion of the CCF, sacrifice of the ipsilateral internal carotid artery with detachable balloon, coll embolization of the cavernous sinus and secondary pseudoaneurysms, and covered-stem management of the pseudoaneurysms. Results All the direct CCFs were successfully managed endovascularly. Four patients developed a pseudoaneurysm after the occlusion of the CCF with an incidence of pseudoaneurysm formation of 18.2% （4/22）. A total number of 8 patients experienced permanent occlusion of the ICA with a rate of ICA occlusion reaching 36.4% （8/22）. Followed up through telephone consultation from 6 months to 5 years, all did well with no recurrence of CCF symptoms and signs. Conclusion Traumatic direct CCFs can be successfully managed with endovascular means. The pseudoaneurysms secondary to the occlusion of the CCFs can be occluded with stent-assisted coiling and implantation of covered stents.     

The role of interventional radiology in trauma

Introduction Interventional Radiology has evolved into a specialty having enormous input into the care of the traumatized patient.In all hospitals,regardless of size,the Interventional Radiologist must consider their relationships with the trauma service in order to     

The acutely limping child

Acute limping may be the result of multiple pathologies in children. The differential diagnosis varies based on the age of the child. Irrespective of age, the initial imaging work-up includes AP and frog leg radiographs of the pelvis and ultrasound; MRI may sometimes be helpful. In children less than 3 years, infections and trauma are most frequent. MRI is the imaging modality of choice when osteomyelitis is clinically suspected. Between the ages of 3 and 10 years, transient synovitis of the hip and Legg-Calvé-Perthes disease are main considerations but infection, inflammation and focal bony lesions are also considered. In children over 10 years, slipped capital femoral epiphysis also is considered.     

人体中的镭-226、镭-228、钋-210、铅-210

本文报道了广东阳江高本底地区6名、对照地区8名人尸体的骨²²⁶Ra、²²⁶Ra的浓度以及部分居民内脏器官中。²¹⁰Po、²¹⁰Pb的浓度。结果轰明阳江高本底地区和对照地区居民骨镭-226、镭-228的浓度分别为29.9pCi/kg, 26.9pCi/kgl 8.7pCi/kg, 8.2pCi/kg.由此估算出阳江高本底地区屠民骨中²²⁶Ra、²²⁸Ra的负薄璧及对骨衬、骨髓所产生的剂量当量分别为对照地区民民的3.4倍, 3.3倍。两地区居民内脏器官中^{210Po、210Pb的测定分析铡数较少但仍看出, 高本底地区均明显高于对照地区.}     

Do Balance Board Training Programs Reduce the Risk of Ankle Sprains in Athletes?

Introduction Ankle sprains are the most common musculo-skeletal injury that occurs in athletes,particularly in sports that require jumping and landing on one foot such as soccer,and basketball(1-4).These injuries often result in significant time loss from participation,long-term disability,and have a major impact on health care costs and resources(5-8).