布氏菌保护性抗原及人对布氏菌感染的免疫反应

世界各国对动物布氏菌病的研究主要集中于诊断方法和菌苗免疫,对人布氏菌病的研究涉及到应用链霉素、四环素等抗生素治疗。尽管如此,至今动物和人布氏菌病仍在世界许多地区流行。只有少数发达国家通过严密的监视系统根除牛布氏菌病。     

急性布鲁氏菌病治疗总结

布鲁氏杆菌是细胞内寄生菌,主要寄生于巨噬细胞内,少数巨噬细胞长期带菌,抗布氏菌药物和抗体不易进入细胞内,因此,布氏菌病治疗往往不彻底,易复发。国内几十年来治疗急性布氏菌病的基本方法是口服四环素,肌注链霉素。虽然布氏菌对四环素非常敏感(抑菌浓度为0.01—0.005微克/毫升),且四环素可少量地渗入细胞内,     

90年代我国布氏菌病治疗研究概况

随着布氏菌病（简称布病）防治工作的不断深入,布病的临床工作正日趋完善,特别是近１０年来,布病的治疗方法、治疗软果及药理研究均取得了可喜的成绩。１ 急性期布病的治疗 抗生素是治疗急性期布病的首选药物［１］,自５０年代开始应用链霉素加四环素或链霉素加磺胺类药,到了８０年代中期则开始应用强力霉素或强力霉素加利福平。高秀萍等［２］用抗生素共治疗４９５例急性期布病患者,链霉素加四环素族类（包括四环素、金霉素、土霉素）治疗１５５例,有效串为９１．５％,链霉素加磺胺类药治疗１０３例,有效率为８１．５％,强力霉素…     

利福霉素钠联合多西环素治疗急性布氏杆菌病疗效观察

目的探讨利福霉素钠联合多西环素治疗急性布氏杆菌病的临床疗效。方法60例急性布氏杆菌病患者被随机分为2组,分别用利福霉素钠联合多西环素治疗(治疗组)或链霉素加多西环素治疗(对照组)。结果治疗组30例,总有效率96.7%;对照组29例,总有效率75.9%,差异有显著性(P<0.05),且治疗组较对照组不良反应明显减少。结论利福霉素钠联合多西环素治疗急性布氏杆菌病是一种有效的治疗方法。     

急性期布氏菌病治疗方法的研究

目的 探索急性期布氏菌病新的有效治疗方法.方法 根据药物敏感试验选定的药物,对1639例急性期布氏菌病患者用头孢曲松钠伍用阿奇霉素进行治疗观察.结果 在治疗的1639例患者中总有效率为99%,疗效显著.结论 用头孢曲松钠伍用阿奇霉素治疗急性期布氏菌病疗效显著,且无明显不良反应,可以推广应用.     

靠血清凝集反应诊断布氏菌病失误一例报告

在临床上常有一些疾病的症状与布氏菌病很相似,当检验报告血清凝集反应阳性,即不再进一步鉴别,便被确诊为布氏菌病,容易造成误诊。我们遇到一例恶性网状细胞病,误诊为布氏菌病,经查     

河北省2001～2004年布氏菌病疫情监测分析

目的 通过对2001～2004年全省的布氏菌病疫情监测结果分析，为防治提供科学依据。方法 汇总2001～2004年的布氏菌病疫情及监测总结并进行分析。结果 人间血检阳性率3．50％，确诊病人157例；畜间羊平均阳性率0.11％，牛平均阳性率0．02％。4年间全省共发生布氏菌病病人2119例，发生布氏菌病疫点26个。结论 河北省布氏菌病疫情呈上升的趋势，从外地引进未经检疫的布氏菌病病畜导致疫情扩散。     

广西人间猪种布氏菌病临床表现及其治疗效果分析

总结分析了广西人间猪种布氏菌病的临床表现和四种治疗方法的治疗效果比较。临床表现以慢性为主，较羊种布病为轻。８０年代较６０￣７０年代临床表现轻型和不典型。四种治疗方法的总治愈率为４０．１４％，总有效率为８９．５９％。以中医中药治疗效果最好，治愈率为６４．４５％，有效率为９５．５６％。     

加味四逆散治疗慢性布氏菌病的实验研究

在布氏菌病发病机理研究的基础上，选择相应中药，采用动物实验，抑菌试验，采用加味四逆散方药，作了实验研究。经过治疗感染后的小鼠脏器病理性组织损伤基本恢复正常。脏器平均分菌率由治疗前的８８．９％，减少到仅有个别小鼠的个别脏器有菌。血清抗体下降，皮肤过敏反应有所减弱，对照组则无明显改变。临床观察，治疗后的病人，各种症状减少或消失，尤其是对关节疼痛及运动功能障碍效果显著。Ｅ花结试验显示治疗后病人细胞免疫功能明显提高。近期和远期总有效率都在９５％以上。其中治愈率分别为８４．２％和７８．９５％。     

就诊于风湿科的布氏菌病60例临床分析

布氏菌病是布氏杆菌引起的急性感染性传染病,近些年,急性布氏菌病患者中有10％～209／6的患者可合并关节感染,亚急性或慢性感染,特别是感染时间超过6个月的患者中,有50％～60％的患者合并关节病变。所以关节痛成为患者就诊的主要原因时,常发生误诊或漏诊。现将我院风湿门诊收治的60例以关节痛为主诉就诊的布氏菌病患者作一回顾性分析。     

Treatment of rectal prolapse in children with cow milk injection sclerotherapy： 30-year experience

AIM： To evaluate the role and our experience of injection sclerotherapy with cow milk in the treatment of rectal prolapse in children.
METHODS： In the last 30 years （1976-2006） we made 100 injections of sclerotherapy with cow milk in 86 children, In this study we included children who failed to respond to conservative treatment and we perform operative treatment.
RESULTS： In our study we included 86 children and in all of the patients we perform cow milk injection sclerotherapy. In 95.3% （82 children） of patients sclerotherapy was successful. In 4 （4.7%） patients we had recurrent rectal prolapse where we performed operative treatment. Below 4 years we had 62 children （72%） and 24 older children （28%）. In children who needed operative treatment we performed Thiersch operation and without any complications.
CONCLUSION： Injection sclerotherapy with cow milk for treatment rectal prolapse in children is a simple and effective treatment for rectal prolapse with minimal complications.     

Lˈallergie au lait de vache du nourrisson

Strictly speaking, allergy to cow’s milk should only be diagnosed if reproducible abnormal reactions are observed and are confirmed by specific reactions in immunological tests. In practice, diagnosis is usually based on reactions following the consumption of cow’s milk, with or without immunological confirmation. It would be logical to describe cases with immunological confirmation as allergy, and those without as intolerance to cow’s milk. However, the possibility of cow’s milk intolerance progressing to become an allergy blurs this distinction. As for many other childhood allergies, the number of cases of cow’s milk allergy diagnosed is clearly increasing. Before 1950, cow’s milk allergy was considered to be very rare. In developed regions, cow’s milk allergy is now suspected to affect at least 10% of infants, and has been confirmed in more than 5% of children. An estimated 0.4–0.5% of cases occur in children who were entirely breastfed before weaning. We began by studying replacement foods, providing efficient supplementation on the elimination of cow’s milk from the diet. We are currently studying the mechanisms of cow’s milk allergy, which often begins when the child is very young, possibly even during the gestation period in some cases.     

Effectiveness of allergy testing in milk induced eosinophilic esophagitis. Description and follow-up of patients

IntroductionEosinophilic esophagitis (EoE) is a chronic, local immune-mediated esophageal disease that has been on the increase lately. There is currently enough evidence to conclude that EoE is an allergic disorder triggered by food allergens, with cow’s milk (CM) being the most frequent. Dietary intervention is the first-line approach. This study aimed to assess the clinical characteristics, the diagnostic method, and the prognosis of patients whose culprit food was CM, as opposed to other triggers.MethodsChildren with EoE evaluated in our pediatric Allergy Department were retrospectively studied from 2004 to 2017. We collected clinical variables, diagnostic protocol, treatment, and follow-up data. We compared patients whose culprit food was CM and patients with EoE due to other causative agents.ResultsWe analyzed 31 children with EoE and found the causative food to be cow’s milk in 14 (45%). Clinical characteristics were similar in patients with EoE due to milk or any other cause. Eight of 14 patients with milk-induced EoE (57.14%) presented positive skin prick test results against cow’s milk. All patients had positive IgE against cow’s milk. None of the patients had any other food as the trigger. The median follow-up was 2.68 years (6 months to 9 years) with initial remission of 100%.ConclusionTesting-based elimination diets effectively treated all of the patients with milk-induced EoE. The advantage of this diagnostic protocol is that it required a mean of only two foods to be tested, significantly smaller number than in empiric diets.     

贺氏针灸三通法治疗带状疱疹的临床疗效观察

目的观察贺氏针灸三通法治疗带状疱疹的疗效。方法将103例患者随机分为三通法组(53例)和西药组(50例),分别采用贺氏针灸三通法和西药治疗。结果三通法组总有效率为100.0%,痊愈率为81.1%。西药组总有效率为82.0%,痊愈率为56.0%。贺氏针灸三通法组疗效优于西药组,差异有统计学意义(P0.05)。结论贺氏针灸三通法治疗带状疱疹具有疗效显著、止痛结痂快、疗程短、后遗神经痛发生率低等优点。     

支气管结核单纯化疗和介入综合治疗近期效果观察

目的　探讨经支气管镜介入局部注药及高频电清除的方法 治疗支气管结核的效果。方法 97例支气管结核病人在全身抗结核治疗基础下随机分为3组,即单纯化疗、支气管镜下进行高频电治疗和局部注药介入治疗进行近期效果观察。结果 高频电组:平均治疗1.8次,有效率97.7%;局部注药组。平均治疗9.1次,有效率88.5%;单用抗结核治疗,有效率55.5%。结论 支气管结核临床易漏诊,经支气管镜介入局部注药或高频电加局部注药治疗均有良好的治疗效果,而后者更快速有效。     

广东鼠疫静息期小肠结肠炎、假结核耶尔森氏菌流行病学调查

目的查明广东省鼠疫静息期动物间及蚤小肠结肠炎、假结核菌感染情况。方法采集鼠类回盲部内容物和猪、牛粪便分别放入改良PBS缓冲液中,置4℃增菌3周,经KOH溶液处理后,涂布IN培养基; 蚤类直接拉胃接种IN培养基,置28℃24 h,挑取可疑菌落鉴定。结果疫源地从鼠、猪粪、蚤、死猪分离出小肠结肠炎耶尔森氏菌61株,血清型0：3（40株）,0：9（21株）和假结核耶尔森氏菌1株。非疫源地从鼠分离出小肠结肠炎耶尔森氏菌2株、中间型耶尔森氏菌1株。结论广东目前动物间小肠结肠炎耶尔森氏菌感染普遍,猪感染率最高,局部已暴发流行,假结核耶尔森氏菌偏低,鼠疫处于静息期。     

IgE-Mediated Cow’s Milk Allergy in Children

The age at which the majority of children outgrow cow??s milk allergy now appears to be later than previously reported. Recent studies have attempted to elucidate factors that may help prevent cow??s milk allergy, assess markers of persistence, and evaluate the usefulness of new diagnostic methods. Strict avoidance of cow??s milk has been the mainstay of treatment. However, given the potential nutritional, social, and immunologic ramifications of cow??s milk elimination from a child??s diet, there has been a focus on reevaluating this therapeutic approach.     

干扰电 牵引 蜡疗 电针联合治疗腰椎间盘突出症的疗效观察

目的观察干扰电、牵引、蜡疗、电针联合治疗腰椎间盘突出症的临床疗效。方法选择腰椎间盘突出症患者90例,按就诊顺序编码半随机分为观察组和对照组各45例。观察组45例采用干扰电、牵引、蜡疗、电针联合治疗,对照组45例采用牵引、蜡疗、电针联合治疗,比较两组的治疗效果。结果观察组总有效率为95.6%,对照组总有效率为84.4%,观察组总有效率高于对照组,但两组比较差异无统计学意义（P〉0.05）。结论干扰电、牵引、蜡疗、电针联合治疗腰椎椎间盘突出症疗效优于对照组,值得临床推广应用。     

心房起搏法在射频消融房室结折返性心动过速中的应用

将射频消融治疗的９４例房室结折返性心动过速（ＡＶＮＲＴ）病人按心房起搏法和常规法进行分组（分别为３９及５５例），回顾性比较两组病人的消融治疗结果，以评价这两种方法在射频消融治疗ＡＶＮＲＴ中的安全性、成功率和复发率。随访１０．８±４．５个月，总成功率为９６．８％、复发率为２．１％。与常规组相比，起搏组有效放电时间明显延长（１４５±３８ｓｖｓ８２±２６ｓ，Ｐ＜０．０１）、慢径阻断成功率高（６１．５％ｖｓ４０．０％，Ｐ＜０．０１）、一过性房室阻滞发生率低（２．６％ｖｓ１２．７％，Ｐ＜０．０５），但各种类型的永久性房室阻滞发生率和复发率无显著性差异（Ｐ＞０．０５）。表明ＡＶＮ－ＲＴ消融术中采用心房起搏法较常规法更为安全有效。     

地塞米松鼓室内注射与静脉给药治疗突发性聋的疗效观察

目的比较地塞米松鼓室内注射与静脉给药治疗突发性聋的临床疗效。方法将180例初次治疗的突发性聋患者分为A组和B组,每组90例,两组根据听力损失程度又分为A1、A2组和B1、B2组,PTA≤70dB患者为A1、B1组,PTA〉70dB患者为A2、B2组。A组采用常规疗法加静脉注射地塞米松治疗,B组采用常规疗法加鼓室注射地塞米松治疗,比较各组治疗效果。结果（1）B组临床疗效和总有效率均优于A组（P均〈0．05）。（2）A1组总有效率为72．oo％（36／50）,A2组总有效率为40．00％（16／40）,B1组总有效率为81．25％（39／48）,B2组总有效率为61．90％（26／42）;A1组与A2组、B1组与B2组及A2组与B2组差异有统计学意义（P〈0．05）,而A1组与B1组差异无统计学意义（P〉0．05）。结论同一种治疗方法,听力损失程度与疗效有密切关系,因此对PTA≤70dB的患者应根据患者的实际情况决定给药途径,而对PTA〉70dB的患者,如情况允许应尽可能用鼓室注射地塞米松治疗。