固精壮阳胶囊治疗男性性功能障碍150例

人类性生活除了传宗接代、繁衍种族的功能外，也是正常的生理需要。人们有权享受健康愉快的性生活，它既关系男性的生活质量，亦影响着家庭幸福和社会安定。因此，在高度开放和社会文明发展的今天，“谈性色变”的封建禁锢应该成为过去，人们应该勇于讨论自身的性问题，特别是正视性功能障碍的疾病。男性的功能障碍中最主要的问题是勃起功能障碍，中医学称之为“阳痿”，     

环状皮疹表现的二期梅毒1例

临床资料 患者女,42岁,农民.因口周、颈部散在环状皮疹2个月,伴轻度瘙痒来诊. 患者自诉无明显透因于2个月前颈后部出现散在红色丘疹,逐渐向周围扩大成环形,轻度瘙痒,在当地诊断为"真菌感染",用搞真菌药丁克治疗无效,类似皮损逐渐发展至颈侧、口周及舌黏膜,并同时有口腔溃疡.患者否认非婚性接触史,否认外阴溃疡史.     

口服特比萘芬治疗甲癣导致味觉丧失1例

临床资料患者男，71岁。因双趾甲变色、增厚、粗糙伴残缺不全20余年来诊。皮肤科检查：双趾甲全部色泽改变，变黄、变黑，大部分趾甲增厚、变脆粗糙及残缺不全。病甲碎屑真菌镜检：见到菌丝和孢子。诊断：甲癣。患者素来体健，否认肝、肾疾患史，及其它主要脏器疾患，查肝、肾功能均正常。给予盐酸特比萘芬（商品名：兰美抒，北京诺华制药有限公司生产）0．25qd，连续3个月。嘱患者中饭或晚饭后即服。患者服用兰美抒37天后，出现味觉丧失，马上嘱其停药。立即予复查肝、肾功等生化全套。均未见异常，患者除味觉丧失外，无腹胀，食欲降低，恶心等胃肠道症状及其它不适反应。停药后6周左右患者味觉渐全部恢复，前后味觉恢复时间约1周。     

湿疹样银屑病误诊传染性湿疹样皮炎1例

临床资料 患者男,42岁.因左小腿丘疹,溃疡,结痂10余年,加重半月,于2007年1月8日就诊.10余年前无明显诱因左小腿出现1个约黄豆大丘疹,搔抓后有渗液、溃烂、结痂,自觉瘙痒.自行使用外用药(具体药物不详)后皮疹可减轻,但反复发作.半月前左小腿再次出现溃疡、渗液,自觉瘙痒,当地医院治疗无效,遂来我科就诊.     

巨大脂溢性角化病1例

脂溢性角化病是常见的表皮良性肿瘤,直径一般不超过3 cm,我科遇到一巨大皮损病例,现报道如下. 临床资料 患者男,82岁,退休工人.因右颞部头皮肿物3年余,快速生长6个月而就医.患者既往体健,近20年头面、躯干及上肢皮肤不断出现绿豆至黄豆大小黄褐色及黑褐色扁平皮疹,无自觉症状,不能自行消退.3年前右侧颞部头皮出现一黑褐色扁平斑块,缓慢生长,近半年快速长大超过核桃大小,影响侧卧,有时瘙痒,无其他不适.否认各种慢性病史.     

大学生性知识来源和性教育需求的调查与分析

为了解大学生的性知识来源，寻求性教育的内容和方式，我们采用问卷调查的方法，对泰山医学院231名大学生进行调查。调查结果表明大多数大学生（67．3％）没有接受过正规的性教育；在获取性知识的途径上存在接受学校教育的比例较低与学生对学校教育认可度较高并存的现象。因此为保证大学生的健康成长，建议高校应加强大学生的性教育工作。     

珍惜朝阳人生

地铁车厢里，一对少男少女热烈相拥；公园绿荫下，“亲密”的男孩女孩勾肩搭背、呢喃私语；中学校园里，一男一女相依相偎——中学生谈恋爱早已不是凤毛麟角的新闻。上海市社科院青少年研究所的一项调查显示，市重点中学大约有10％左右的学生有谈恋爱的行为，而在一般中学和职业技术类学校中，比例更高，有的甚至达到了50％。     

46例系统性硬皮病临床分析

回顾性分析46例系统性硬皮病患者的临床资料,探讨其首发症状、皮肤损害、实验室检查及治疗的特点,以利于系统性硬皮病的早期诊断、治疗,减少脏器损害,改善预后.结果:本组病例中首发症状主要为雷诺现象、关节痛、皮肤肿胀硬化,其中以雷诺现象为首发者有19例(41.3%),在整个病程中其发生率为67.4%;本文检测44例患者中ANA阳性32例(72.7%),38例检测Scl-70阳性12例(31.6%),全身各系统均有不同程度的累及,以心肺损害较常见;以综合治疗为主.根据疾病不同时期、临床表现,做到早期诊断、治疗,预防内脏器官的损害.     

性交后出血与宫颈病理学改变的关系

目的探讨性交后出血与宫颈病理学改变的关系.方法通过对2002年6月至2007年6月168例以性交后出血为主诉的患者进行宫颈刮片细胞学检查,对其中刮片异常的58例进行病理学检查并与同期刮片异常但无性交后出血者进行配比研究.结果58例宫颈刮片细胞学检查阳性,明确诊断宫颈癌或腺癌者16例.结论有性交后出血者宫颈癌的发生率明显增加,但有多种宫颈病变可能造成性交后出血.宫颈刮片细胞学检查阴性并不能排除宫颈CIN或浸润癌的可能.应行阴道镜检查及宫颈的活体组织病理学检查.     

无黑素恶性黑素瘤1例

临床资料 患者男,53岁.左拇趾肿物2年余,无明显自觉症状.患者于2000年春被牲口踩伤左拇趾,表面未破溃,数日后疼痛自行缓解.2个月后走路时感到左拇趾疼痛,去当地诊所.见甲板纵裂,有脓血水流出.X片示趾骨无异常,即行拔甲、清创并给予口服抗生素.创面一直不愈合,出现溃烂、肉芽增生,流血性分泌物及少量黄绿色脓液.2002年3月5日在当地医院截除溃烂的拇趾末端,术后不久趾末端又开始增生、破溃.2003年11月5日来我院骨科就诊,查无骨损害,转来我科.     

Outcomes and adverse effects of ablative vs nonablative lasers for skin resurfacing: A systematic review of 1093 patients

It is generally believed that ablative laser therapies result in prolonged healing and greater adverse events when compared with nonablative lasers for skin resurfacing. To evaluate the efficacy of ablative laser use for skin resurfacing and adverse events as a consequence of treatment in comparison to other modalities, a PRISMA‐compliant systematic review (Systematic Review Registration Number: 204016) of twelve electronic databases was conducted for the terms “ablative laser” and “skin resurfacing” from March 2002 until July 2020. Studies included meta‐analyses, randomized control trials, cohort studies, and case reports to facilitate evaluation of the data. All articles were evaluated for bias. The search strategy produced 34 studies. Of 1093 patients included in the studies of interest, adverse events were reported in a total of 106 patients (9.7%). Higher rates of adverse events were described in nonablative therapies (12.2% ± 2.19%, 31 events) when compared with ablative therapy (8.28% ± 2.46%, 81 events). 147 patients (13.4%) reported no side effects, 68 (6.22%) reported expected, transient self‐resolving events, and five (0.046%) presented with hypertrophic scarring. Excluding transient events, ablative lasers had fewer complications overall when compared with nonablative lasers (2.56% ± 2.19% vs 7.48% ± 3.29%). This systematic review suggests ablative laser use for skin resurfacing is a safe and effective modality to treat a range of pathologies from photodamage and acne scars to hidradenitis suppurativa and posttraumatic scarring from basal cell carcinoma excision. Further studies are needed, but these results suggest that ablative lasers are a superior, safe, and effective modality to treat damaged skin.     

New fillers for the new man

ABSTRACT:  Two new collagen-based lidocaine-containing dermal fillers, ArteSense™/ArteFill™ (Artes Medical, San Diego, CA) and Evolence® (Colbar LifeScience Ltd., Herzliya, Israel), have proved to be of particular interest to men, many of whom seek a long-lasting or permanent correction. ArteFill™ has been available in the United States since 2006, and it is expected that Evolence® will reach the American market in 2008. The properties of the two products will be described, and experience based on the administration of many hundreds of syringes of both products by a Canadian dermatologist will be detailed here, with tips and precautions to optimize patient outcomes.     

Multiple New-Onset Subcutaneous Nodules of the Upper Extremity Digits: Giant Cell Tumor of Tendon Sheath and Lipoma

A black woman with the concurrent onset of two subcutaneous nodules located on the digits of her upper extremities is described. Initially, a single systemic disorder was considered; yet, the lesions differed in morphology and consistency. Microscopic examination of the nodules showed a giant cell tumor of tendon sheath and a lipoma. Although Occam's “razor” suggests that multiple lesions in the same person are more likely to represent variable manifestations of a single disorder than several different diseases in that individual, the simultaneously appearing lesions in this patient represented two different conditions.     

Genetic alterations in RAS‐regulated pathway in acral lentiginous melanoma

Studies integrating clinicopathological and genetic features have revealed distinct patterns of genomic aberrations in Melanoma. Distributions of BRAF or NRAS mutations and gains of several oncogenes differ among melanoma subgroups, while 9p21 deletions are found in all melanoma subtypes. In the study, status of genes involved in cell cycle progression and apoptosis was evaluated in a panel of 17 frozen primary acral melanomas. NRAS mutations were found in 17% of the tumors. In contrast, BRAF mutations were not found. Gains of AURKA gene (20q13.3) were detected in 37.5% of samples, gains of CCND1 gene (11q13) or TERT gene (5p15.33) in 31.2% and gains of NRAS gene (1p13.2) in 25%. Alterations in 9p21 were identified in 69% of tumors. Gains of 11q13 and 20q13 were mutually exclusive, and 1p13.2 gain was associated with 5p15.33. Our findings showed that alterations in RAS‐related pathways are present in 87.5% of acral lentiginous melanomas.     

Deutliche Einschränkung der Lebensqualität bei Patienten mit Pemphigus vulgaris: Ergebnisse der deutschen Bullous Skin Disease (BSD)‐Studiengruppe

Background: Pemphigus vulgaris is a potentially life‐threatening autoimmune disorder of the skin and mucous membranes characterized by antibodies against epidermal adhesion molecules. Clinically characteristic are painful chronic blisters or erosions of mucous membranes and skin. There are no published studies on the impact o this disease on quality of life. Patients and methods: This registration was performed within the scope of the German BSD (Bullous Skin Disease) study group, from November 1997 until January 2002. A total of 36 patients with the first diagnosis of pemphigus vulgaris were registered at the university hospitals of Dresden, Erlangen, Kiel, Mannheim, München and Würzburg. Thirty of the 36 (83 %) patients participated in the quality of life questionnaire utilizing the German version of ‘Dermatology Life Quality Index’ (DLQI) provided by A. Y. Finlay. The DLQI varies from 0 to 30 with an increased DLQI score indicating a decrease in quality of quality. Results: The overall DLQI total score of 10 ± 6,7 in the investigated pemphigus patients was significantly increased in comparison to other skin diseases. Conclusions: These results suggest that the DLQI can be a very useful additional outcome criteria for clinical studies with pemphigus vulgaris and in the treatment of these patients.     

Medición del impacto psicológico en pacientes con psoriasis en tratamiento sistémico

Background and objectives

The negative impact of psoriasis on patient quality of life can be as important as the physical consequences of the disease. We could assume that clearance of the disease would also lead to an improvement in its psychosocial impact. The present study assesses the psychological state of patients with psoriasis receiving systemic treatment in a psoriasis unit, especially those with mild or no disease involvement.

Mutations in mevalonate pathway genes in patients with familial or sporadic porokeratosis

Porokeratosis comprises heterogeneous keratinization disorders that are characterized by one or more atrophic patches surrounded by a ridge‐like cornoid lamella. In this study, we evaluated seven families affected by porokeratosis and five sporadic patients of the disease in a Chinese population. We performed Sanger sequencing of exons and flanking intron–exon boundaries of mevalonate pathway genes (MVD, MVK, PMVK and FDPS) and of SLC17A9. In five familial and three sporadic patients, we detected six variations, including four novel mutations (MVD c.1A>G; p.Met1?, c.916G>A; p.Ala306Thr, c.1013+1G>A, and PMVK c.65A>G; p.Lys22Arg) and two recurrent mutations (MVD c.746T>C; p.Phe249Ser, and MVK c.1028T>C; p.Leu343Pro). We then applied I‐TASSER and iGEMDOCK to assess these variants for probable functional impacts. The findings of this study extend the mutation spectrum of porokeratosis and provide further evidence for the genetic basis of this disease.