药物避孕

950343 Norplant皮T埋植避孕峨40例临床总结/许豪勤…//中国计划生育学杂志一1994,2“一5).一263~264 本文作者给平均年龄40岁的育岭妇女440例皮下埋植避孕剂Norplant后.3年61、月的累积妊娠率为。,使用率为90.2%,因症取出率9.8%.使用者有轻重不一的出血副反应,尤其是在使用的最初几个月淋漓不尽者甚多,另有少数使用者月经稀薄或闭经长达二年.绝大部分使用者体重均增加。.5 。68。kg/年。血压无升高变化.2例分别于8、12月发现乳房纤维瘤,3例分别于8、16、24月发现子宫肌瘤和卵巢肿瘤,使用Norplant前均无该症.应进一步探索.作者认为,Norpla…     

米非司酮治疗皮埋避孕药致月经紊乱131例疗效观察

左旋-18甲基炔诺酮（Norplant）皮下埋植避孕,避孕效果好,避孕率100%,但有月经紊乱的副作用,包括经期延长、点滴出血、闭经等,是终止使用的主要原因。     

Norplant皮下埋植避孕法四年的临床及实验研究

我院于1986年3月至1990年3月应用 Norplant 埋植剂1125例,其避孕率为100%,持续使用率为95.38％,被埋植者除月经不规则、阴道点滴出血时间较长外,无其他明显不适.定期复查血压、体重、血红蛋白、血小板、免疫球蛋白、肝功能、心电图等均无明显异常.动物实验显示对肝脏结构与功能无损害.妇检及宫颈刮片未发现癌前病变。临床及实验研究表明,此法安全可靠、使用简单、避孕率高、副作用少,值得推广应用.     

依托孕烯皮下埋植避孕的临床经验和可接受性

目的:评价一种依托孕烯皮下单棒避孕埋植剂的有效性、副作用及受试者的持续使用率。方法:共417例育龄健康志愿者参加了此项多中心试验。埋植剂植入后,就避孕作用对受试妇女随访3年。每次随访均记录其临床症状、副作用及阴道出血情况。分别应用珀尔指数和Kaplan-M eier生命量表分析有效性和持续使用率。结果:观察了总共958.5个(妇女·年)(每个妇女27.5月)。珀尔指数评分为0。44.4%的使用者报告有副作用,但到研究结束时此比例降至16.5%。持续使用率为61.4%。早期终止使用(占受试者的21.1%)最常见的原因为月经紊乱。结论:依托孕烯皮下避孕埋植…     

药物避孕

94104。国产长效皮下埋植避孕剂的临床应用/王英华…//中国妇幼保健一1994,9(3)一49 该院1992年试用国产长效皮下埋植避孕剂(左旋18一甲基快诺酮),对600例育龄妇女皮下埋植并进行可行性研究。结果:600例随访一年,随访率达100%,无一例妊娠,避孕效果达100%。其中10例因月经异常终止使用,持续使用率为98.33%。埋植后血红旦白较植前有所增加,差异有显著意义。肝功能各项检查结果均在正常值范围内。副反应:随访一年无副反应者461例,占76.183肠,阴道不规则出血12。例占20.34%,闭经者12例占2.03%,头晕者6例占1.02%.皮疹者1例占0.17%,终止使用者10例…     

兰州地区妇女应用Norplant皮下埋植避孕法623例临床观察

我们于1986年3月开始对兰州地区妇女应用Norplant皮下埋植避孕法进行观察与研究,至1987年5月31日共埋植623例,经随访全部使用满5年,累计妊娠率为1.61％,继续使用率为78.81％,月经紊乱是终止使用的主要原因,占总终止数的72.73％;其他医学原因终止仅占2.25％。表明Norplant皮下埋植剂是安全有效的避孕法。     

药物避孕

031581皮T埋植剂Imp一anon和Norplant的临床对比性研究澎七晓英…//中华妇产科杂志一2003,38(7)一419一422 比较皮下埋植剂(Implanon)和皮下埋植剂(N叩lant)避孕的有效性、可接受性和阴道出血的情况。方法:采用随机对照的前瞻性研究方法,将1朋例健康妇女,分为两组,使用Implanon75例(Im-planon组),使用255 .5妇女年;使用Norplant 25例(Norplant组),使用94 .4妇女年,共随访4年,进行临床比较性研究。结果:两组均无妊娠发生。以90d为l个参照时限,Implanon组的阴道出血(出血或滴血)天数,由第1个参照时限平均33d,减少至第16个参照时限的Zld;N…     

皮下埋植避孕剂Norplant的一年临床应用

本文报道应用Norplant皮下埋植剂250名和Norplant-2 50名以控制生育。12个月的避孕效果:妊娠率分别为0.4％和0,持续使用率分别为94.8％和96％。因症取出率分别为4.8％和4％。其主要原因为副反应如月经不规则。埋植剂使用者12个月末体重变化不显著,而收缩期血压及舒张压较使用前略有下降,均有统计学意义。对停止使用的对象进行随访,月经很快恢复正常,有4名已妊娠。埋植剂的放置和取出易于掌握,在1,150名次使用中未发生感染或其他手术并发症,深为受试者所欢迎。     

皮下埋植避孕的临床效果158例分析

目的 评价皮下埋植避孕的临床效果及不良反应.方法 对158例已过有效期的皮埋者在感染、妊娠率、副反应、终止率、继续使用率等方面进行回顾性分析.结果 皮埋剂避孕是一种高效避孕措施,但月经紊乱是最突出的副反应,也是终止使用的主要原因.结论 皮下埋植剂用于避孕是一种操作简单、高效、长期的避孕措施,特别是用于因子宫因素不能放置宫内节育器者.但要重视放置后的随访工作,并作一些必要检查,尽早发现一些不良反应.     

新办法让处方更规范

目的 评价皮下埋植避孕的临床效果及不良反应.方法 对158例已过有效期的皮埋者在感染、妊娠率、副反应、终止率、继续使用率等方面进行回顾性分析.结果 皮埋剂避孕是一种高效避孕措施,但月经紊乱是最突出的副反应,也是终止使用的主要原因.结论 皮下埋植剂用于避孕是一种操作简单、高效、长期的避孕措施,特别是用于因子宫因素不能放置宫内节育器者.但要重视放置后的随访工作,并作一些必要检查,尽早发现一些不良反应.     

A Multicenter Comparative Clinical Study of Sino-Levonorgestrel-Releasing Implants— No. I and No. II withNorplant

Norplant is a contraceptive method developed by the Population Council based on 20years’ research[1]. Atpresent, Norplanthas been used worldwide and is produced in Finland.It was introduced into China in 1984, and registered officially in 1987 after a study on itsacceptability and clinical trial application[2]. The main merits of the implant are its high andlong-acting effectiveness, convenience and reversibility. By the late 80s, two types of sub-dermal implants No.I (Cla) and No.II (Si…     

A Multicenter Comparative Clinical Study of Sino-Levonorgestrel-Releasing Implants-No.Ⅰ and No.Ⅱ with Norplant

Objective To compare the efficacy, side effects and acceptability of two Sino-implants with NorplantMethods A randomized, prospective multicenter comparative clinical study was conducted in 10 clinical centers in China.Results Totally 1 001, 1 000 and 998 cases were recruited for Sino-implant No. Ⅰ, No.Ⅱ and Norplant, respectively, in 1993. The follow-up rate was 99.8% totally in 5 years.Three and five pregnancies occurred respectively in Sino-implant No. I and No. Ⅱgroup, while no pregnancy occurred in the Norplant group. The cumulative pregnancy rate was 0.4, 0.7 and 0 per 100 women respectively in implant No.Ⅰ, No. Ⅱ and Norplant group for five years, meaning that there was no statistical difference. There was no ectopic pregnancy in the three groups. The cumulative discontinuation rates at the end of five years were not significantly different among the three groups, either. Menstrual problems were the main reason for termination. The menstrual blood loss decreased significantly and no serious health problems arose from implants use.Conclusion The two Sino-implants provided similar high efficacy and safety to Norplant, therefore, they can be used by women at reproductive age who are from different areas, different of races, educational background and occupation.     

两种含铜宫内节育器TCu380A和MLCu375s临床效果的对比研究

报告了随机放置TCu380A和MLCu315s宫内节育器共200例,一年观察结果表明,TCu380A和MLCu375s妊娠率分别为0.0%和2.2%,脱落率分别为8.4%和11.4%,因出血疼痛取出率为8.4%和2.1%,一年的继续存放率分别为84.0%和84.8%,两种节育器比较,差异无显著意义。     

Post-marketing Surveillance for Combined Oral Contraceptive Containing Desogestrel (Marvelon?) in Chinese Rural Areas

Objective To assess the side effects and the continuation rate of combined oral contraceptive (COC) containing desogestrel (Marvelon ) during 12 months. Methods This was a post-marketing surveillance study on Marvelon COC among 870 healthy rural women in 5 different counties of Jiangsu Province during 12 months. Results About 24.02% of the women who used Marvelon COC experienced side effects during 12 months. Gastrointestinal disorder, bleeding/spotting and chloasma were ranked the first three in the side effects. The rate of side effects of Marvelon COC users during the first 3 months in southern area of Jiangsu was significantly higher than that of users in northern area of Jiangsu. Most of the users did not experience obvious weight changes i.e., loss or increase in weight of more than 5 kg during 12 months. Blood pressure and biochemical indicators of almost 99% among users were within the normal range. The gross cumulative continuation rate for 12 months was 83.14%; the most common medical reason for discontinuation was gastrointestinal disorder. There was an increased risk of discontinuation use among women with lower educational level.Conclusion Marvelon COC brought fewer side effects and was well accepted when applied in Chinese rural women.     

皮下埋植避孕剂NORPLANT的临床应用

本文报道我院自1984年10月从人口理事会引进Norplaht~((R))(左旋18-甲基炔诺酮)皮下埋植剂应用于临床,小结了最初放置的Norplant~((R))(6个胶囊)250例和Norplant~((R))-2(左旋18-甲基炔诺酮埋植剂2型、2个胶棒)50例,6个月的避孕效果,包括持续使用率均为97.99％,妊娠率分别为0.4％和0,因症取出率分别为1.6％和2％。最主要的副反应为月经不规则,是头6个月的使用中终止的主要原因。但是总失血量不多。 埋植剂的放置和取出技术经过培训,容易为医护人员所掌握,至今我院已放置656例,未发生感染或其他手术并发症。说明它的应用是安全的,又由于其妊娠率低和不可能脱落,及其高度的可逆性,我国妇女是愿意接受此避孕法的。故容易推广。     

The satisfaction, efficacy, and relative factors for Norplant in countryside of Sichuan]

A total of 1473 Norplant users in the countryside of Sichuan Province were investigated to present a multivariate analysis of satisfaction, side effect, and efficacy for Norplant. The results showed that contraceptive efficacy rate, continuation rate, prevalence rate of side effects and satisfactory rate were 99.3%, 90.6%, 86.4%, and 69.7%, respectively. The logistic regression analysis showed that the variables significantly contributing to satisfaction were the user's knowledge about Norplant, the user's voluntary choice of Norplant, and the spouse's satisfaction. The satisfaction was associated with continuation and the prevalence of side effects. It is concluded that Norplant is efficacious and satisfactory to a certain extent among the users in rural Sichuan; its continuation rate is high but the prevalence of side effects is noticeable. For the wide application of Norplant in the countryside, it is important to strengthen propagation and education.     

皮下埋植避孕法在四川省农村的使用效果、满意度及其影响因素调查

为了解皮下埋植避孕法（简称皮埋法）在农村的实际使用效果、使用者满意度及其对效果的影响，对四川省农村１４７３名皮埋法使用者进行了现场调查。就使用者对该方法的使用效果、满意度及其影响因素进行多因素分析。结果：避孕率达９９．３％，续用率为９０．２％，副反应发生率为８６．４％。对此方法满意的有１０２７例（６９．７％），不满意的２８７例（１９．５％）。满意度主要与家人的满意度、了解皮埋优缺点、是否自愿选择使用皮埋法相关。满意度与手术后副反应的发生及副反应程度、续用率等密切相关。结果提示：皮埋法的避孕效果是肯定的，在农村妇女中有一定的满意度。要进一步在农村推广使用皮埋法，提高其满意度及避孕效果，需加强宣传教育等     

Bleeding patterns and acceptability among Norplant users in Singapore

Norplant contraceptive implants are silastic implants containing levonorgestrel. This study describes our experience with 100 acceptors of NORPLANT implants in Singapore. No pregnancies occurred during the first year of use. The majority found the method's ease of use to be the most attractive feature. Disruption of menstrual rhythm appeared to be the least liked feature. However the incidence of these menstrual irregularities appeared to diminish with time. Implant users have tolerated this early disruption of their menstrual rhythm well and the continuation rate at the end of the year was 97%. Thus it appears that Norplant is a safe, effective and acceptable method of contraception.     

节育器Norplant－2和LNG－IUD临床使用的比较研究

随机放置女性节育器Ｎｏｒｐｌａｎｔ－２或释放孕激素的宫内节育器ＬＮＧ－ＩＵＤ各１００例观察３年，仅一例使用ＬＮ０－ＩＵＤ者妊娠。ＬＮＧ－ＩＵＤ累积脱落率为４．０／每百妇女。Ｎｏｒｐｌａｎｔ－２与ＬＮＧ－ＩＵＤ不规则出血停用率分别为２６．８／每百妇女年和３．３／每百妇女（Ｐ＜０．００１）。续用率分别为６９／每百妇女和７５／每百妇女。放置后第三年Ｎｏｒｐｌａｎｔ－２组平均体重较放置前增加１．４ｋｇ（Ｐ＜０．００１）。副作用以不规则出血为主，ＬＮＧ－ＩＵＤ组以闭经为主，但副作用随使用时间的延长有所减轻。本文结果显示，我国妇女对ＬＮＧ－ＩＵＤ引起的闭经比Ｎｏｒｐｌａｎｔ－２引起的经期延长似更易接受，大多数妇女对所用节育器感到满意。     

Norplant使用者子宫异常出血的血管变化

目的： 观察 Ｎｏｒｐｌａｎｔ 致子宫不规则出血时内膜血管的变化, 探讨二者的关系。方法：用组织学和免疫组织化学方法对使用 Ｎｏｒｐｌａｎｔ 后 （０５ 、１ ａ 及＞ ２ ａ） 月经规律及有子宫不规则出血者的子宫内膜进行形态学、内膜血管内皮细胞 Ｃ Ｄ３４ 和基膜层粘连蛋白 （ Ｌ Ｎ） 观察。结果： Ｎｏｒｐｌａｎｔ 使用者子宫内膜均无典型的周期特点, 血管内皮变薄; 出血不规则的内膜血管基膜 Ｌ Ｎ 明显减少。结论： Ｎｏｒｐｌａｎｔ 使用者子宫出血不规则与内膜血管内皮变薄和基膜 Ｌ Ｎ减少有密切关系。