抑郁症患者脑诱发电位的变异特点: 2个月随访观察

目的探讨抑郁症患者脑诱发电位的变异特点及临床应用价值. 方法实验于 2001- 08/2003- 10在解放军一六○医院精神疾病防治中心完成.使用美国 Nicolet Bravo脑电生理仪对符合中国精神障碍分类与诊断标准第三版( CCMD 3)中抑郁症诊断标准的 46例患者(抑郁症组)以及 42名健康志愿者(对照组),进行听觉诱发电位( auditory evoked potential, AEP)、事件相关电位 P300( event related potential P300, P300)的检测.同时抑郁症组完成汉密顿抑郁量表( HAMD)评定.并于治疗 2个月时对抑郁症组进行了相同项目的随访. 结果治疗前与对照组相比,抑郁症组 P300靶 N2和 P3潜伏期均延迟 (t=2.15,4.22, P< 0.05和 0.01),靶 P3和非靶 P2波幅均降低( t=8.24,6.48, P均 < 0.01); AEP双峰 P2波的出现率增高(χ 2=17.68, P< 0.01).治疗后与治疗前比较,抑郁症组 P300大部分变异指标明显变化( t=2.52～ 9.06, P< 0.05～ 0.01),与对照组比较差异均无显著性意义( t=0.83～ 1.75,P均 >0.05); P300非靶 P2波幅与 AEP双峰 P2波的出现率变化不明显,与对照组相比仍有显著性差异( t=6.03,χ 2=13.91, P均 < 0.01); HAMD总分及大部分因子评分明显下降 ,差异有显著性意义 (t=2.56～ 9.61,P< 0.05～ 0.01).治疗前后, P300主要指标的差值与部分精神症状的变化之间有显著相关性( r=0.224～ 0.342,P< 0.05～ 0.01). 结论抑郁症患者脑诱发电位有自己的变异特点,在协助诊断抑郁症方面有一定的价值.     

脑梗死患者胰岛素抵抗状态与血脂代谢异常

目的研究脑梗死患者的胰岛素抵抗状态与血脂代谢异常. 方法测定 2000-05/09在中国医科大学附属二院住院的 44例脑梗死患者的血脂、血糖、胰岛素及 C-肽,与健康对照组( 20例)比较. 结果脑梗死合并高血压组与不合并高血压组的空腹胰岛素( fasting insulin,FINS)、 C-肽、三酰甘油、高密度脂蛋白( high-density lipoprotein,HDL)、载脂蛋白 B(apolipoprotein B,ApoB) 、胰岛素敏感指数( insulin sensitivity index ,ISI) 与对照组比较有显著性差异( P< 0.01) ,空腹血糖 (FBS)、总胆固醇 (TC)、低密度脂蛋白( low-density lipoprotein,LDL)与对照组比较差异有显著性意义( P< 0.05).脑梗死两组间差异无显著性意义( P >0.05). ISI与 FINS( r=- 0.82～- 0.71,P< 0.001), C-肽 (r=- 0.55～- 0.53,P< 0.01), ApoB(r=- 0.46 ～- 0.45,P< 0.05) 及神经功能缺损评分 (r=- 0.56～- 0.58,P< 0.01)呈显著负相关,与 HDL(r=0.50～ 0.55,P< 0.05)呈显著正相关. 结论脑梗死患者存在胰岛素抵抗,胰岛素抵抗与血脂代谢异常关系密切.     

慢性肾衰竭血清晚期糖基化终产物水平的变化及意义

目的探讨慢性肾功能衰竭患者血清晚期糖基化终产物(AGEs)水平的变化、意义及高通量血透对AGEs的清除效果. 方法应用竞争性ELISA法检测慢性肾功能衰竭(CRF)患者(非血液透析组及血液透析组)血清AGEs 水平,同时测血浆脂质过氧化物丙二醛(MDA)含量及超氧化物歧化酶(SOD)活性. 结果 CRF患者无论血液透析与否,血清AGEs均明显高于健康组(P均<0.001),非血液透析与血液透析组AGEs水平无显著性差异(P<0.05),AGEs水平与CRE呈明显正相关(r=0.5974,P<0.01),与血糖无相关性;CRF患者血浆MDA含量明显高于健康组(P均<0.001),SOD活性明显低于健康组(P<0.05).AGEs与MDA、SOD间无相关性;常规血液透析(CHD)组,透析前后血清AGEs水平无显著性差异 (P < 0.05),而高通量血液透析(HFHD)组透析后血清AGEs水平明显降低(P<0.001),两组血浆SOD活性均明显升高(P<0.01),MDA含量明显降低(P<0.01).结论 CRF时,因肾功能受损致AGEs清除障碍,是血清AGEs水平升高的主要原因,同时CRF时氧化应激增强可能也促进了AGEs生成.高通量血液透析可以有效清除血清AGEs,并改善自由基代谢紊乱.     

强骨抗萎方对骨细胞代谢及血液流变学的影响

目的研究中药复方强骨抗萎方对尾吊大鼠血液流变学的影响. 方法 用大鼠尾吊- 30°21 d模拟失重,观察强骨抗萎方对大鼠血沉、血细胞比容、纤维蛋白原、血液黏度及红细胞变形性、聚集性等指标的作用. 结果 悬吊大鼠纤维蛋白原明显升高( P< 0.01),全血还原黏度及全血黏度明显增加( P< 0.01或 P< 0.05),红细胞刚性指数升高( P< 0.01),最大变形指数降低( P< 0.01),最大聚集指数增加( P< 0.01).该方不同剂量显示了不同的作用.低剂量组( 10 g/Kg)可降低各个切变率下的全血还原黏度和全血黏度( P< 0.01或 P< 0.05),以及异常的红细胞刚性指数和最大聚集指数( P< 0.01);中剂量组( 20 g/kg)可使纤维蛋白原含量减少( P< 0.01);高剂量组( 30 g/Kg)可降低高切变率下的全血还原黏度和全血黏度( P< 0.01或 P< 0.05),降低红细胞刚性指数( P< 0.01),并可升高红细胞最大变形指数( P< 0.01). 结论 该方具有改善尾吊大鼠血液流变学的作用,但无明显的量效关系.     

急性白血病细胞bcl-2、Bax和Fas/Apo-1基因表达的研究

目的研究bcl-2、Bax、Fas/Apo-1基因在急性白血病(AL)细胞中的表达及其与AL的分型、临床特征、疗效及预后因素的关系.方法采用免疫组化方法检测54例初治AL骨髓细胞bcl-2、Bax、Fas/Apo-1蛋白表达情况.结果 AL骨髓细胞中bcl-2基因的表达显著高于正常对照组(P<0.05),而Bax、Fas/Apo-1基因的表达显著低于正常对照组(P<0.05).bcl-2、Bax、Fas/Apo-1基因表达在急性髓系白血病(AML)与急性淋巴细胞白血病(ALL)无显著差异;在AML亚型中,bcl-2在M4及M5中的表达高于M1、M2和M3(P<0.05);而Bax及Fas/Apo-1的表达在各亚型中无显著性差异(P>0.05).bcl-2的表达与初诊时的白细胞数呈正相关(r=0.44,P<0.05),与疗效呈负相关(r=-0.40,P<0.05),Bax的表达与骨髓白血病细胞数呈负相关(r=-0.39,P<0.05),与髓外浸润呈负相关(r=-0.45,P<0.05),急性淋巴细胞白血病中 Fas/Apo-1的表达与疗效呈正相关(r=0.34,P<0.05),与骨髓原始细胞数呈负相关(r=-0.71,P<0.05).结论 bcl-2、Bax、Fas/Apo-1基因的紊乱可能在AL的发病中起着重要作用,还与白血病的某些临床特征、疗效及预后因素密切相关.     

血浆B型钠尿肽水平对冠心病左心室收缩功能不全的诊断价值

目的研究冠心病患者血浆B型钠尿肽(BNP)水平与左心室收缩功能的关系.方法用免疫发光法检测30名正常对照者与69例冠心病患者血浆BNP水平,通过纽约心脏病协会心功能分级标准(NYHA)及超声心动图结果对冠心病患者心功能分级.结果对照组、心功能Ⅰ～Ⅱ级组及心功能Ⅲ～Ⅳ级组的BNP水平分别为(31.56±21.48) μg/L、(105.52±91.77) μg/L和(433.18±378.03)μg/L,3组差异均有非常显著性(P<0.001).冠心病患者BNP水平与左室射血分数(LVEF)呈负相关(r=-0.70,P<0.001),其中LVEF≤40%亚组BNP水平显著高于LVEF>40%亚组(P<0.01).结论血浆BNP水平能反映冠心病患者左心室收缩功能,该指标对早期心功能不全患者的检出、心力衰竭程度的评判等具有重要的临床价值.     

p53和Bcl-2基因mRNA在老年急性心肌梗死猝死者心肌细胞凋亡中作用的研究

目的探讨p53和Bcl-2基因在老年急性心肌梗死(AMI)猝死者心肌细胞凋亡中的作用.方法用TUNEL法检测15例老年AMI猝死者和10例心脏正常车祸死亡者的心肌细胞凋亡,用以cDNA为内参标准的逆转录-聚合酶链反应(RT-PCR)的方法检测心肌细胞内p53和Bcl-2基因mRNA表达量,并探讨它们之间的相互关系.结果TUNEL法发现,猝死者梗死区的每千个心肌细胞凋亡数老年AMI猝死组明显高于对照组(P=0.000);猝死者梗死区心肌细胞中p53基因mRNA表达量明显高于对照组(P=0.000),梗死区心肌细胞凋亡数与其中p53mRNA表达量的对数值成明显正相关性(r=0.883,P<0.001);Bcl-2基因mRNA表达量则明显低于对照组(P=0.000),且梗死区心肌细胞凋亡数与其内Bcl2mRNA表达量的对数值成明显负相关性(r=-0.907,P<0.001);猝死者p53和Bcl-2基因的mRNA表达量对数值之间呈明显的负相关性(r=-0.849,P<0.001).不同支数冠脉病变猝死者之间的比较1支、2支和3支病变者在心肌细胞凋亡数、p53和Bcl-2mRNA表达量方面,相互之间比较均无统计学上的差异(可能是因为例数少).结论老年AMI猝死者梗死区心肌细胞存在明显的凋亡现象,且受p53与Bcl-2两者相反调节其凋亡(p53基因上调、Bcl-2基因下调).     

阻塞性睡眠呼吸暂停低通气综合征患者事件相关电位P300及其影响因素分析

目的探讨阻塞性睡眠呼吸暂停低通气综合征（OSAHS）患者事件相关电位（ERP）P300的特点及其影响因素。 方法选取OSAHS患者22例（病例组）和健康正常人18例（对照组）为研究对象,分别进行P300测定,采用相关性分析和逐步多元回归分析法对OSAHS患者睡眠模式、睡眠呼吸暂停低通气指数（AHI）、平均血氧饱和度（MSaO2）、最低血氧饱和度（LSaO2）、非快速眼动（NREM）睡眠第Ⅰ、Ⅱ、Ⅲ、Ⅳ期和快速眼动（REM）睡眠占总睡眠时间的百分比、氧饱和度低于90%的睡眠时间（90％SaO2）等指标与P300潜伏期和波幅间的关系进行探讨。 结果病例组P300中P3波的潜伏期［（344.24±23.99）ms］大于对照组P3波的潜伏期［（311.17±15.65）ms］（P<0.05）,其P3波的波幅［（3.66±1.49）μV］低于对照组P3波的波幅［（6.26±1.48）μV］（P<0.05）。P3波潜伏期与NREMⅠ+Ⅱ占总睡眠时间的百分比（r=0.492,P<0.05）、90％SaO2（r=0.627,P<0.01）、AHI（r=0.882,P<0.01）呈正相关,与NREMⅢ+Ⅳ占总睡眠时间的百分比（r=-0.558,P<0.01）、LSaO2（r=-0.479,P<0.05）、MSaO2（r=-0.519,P<0.05）呈负相关。P3波的波幅与NREMⅠ+Ⅱ占总睡眠时间的百分比（r=-0.491,P<0.05）、90％SaO2（r=-0.626,P<0.01）、AHI（r=-0.866,P<0.01）呈负相关,与NREMⅢ+Ⅳ占总睡眠时间的百分比（r=0.516,P<0.05）、LSaO2（r=0.475,P<0.05）、MSaO2（r=0.514,P<0.05）呈正相关。经过多元线性回归分析后,发现AHI对P300的影响较大。 结论OSAHS患者P300存在异常,其变化与OSAHS患者的病情严重程度具有相关性,其中AHI对P300的影响较大。     

脑卒中偏瘫患者步态的不对称性与平衡功能的相关性研究

目的研究脑卒中偏瘫患者步态时空参数的不对称性与平衡功能之间的相关性。 方法选取可以独立步行10m以上的单侧偏瘫的脑卒中患者30例设为病例组,相匹配的健康中老年人30例设为对照组,采用步态与平衡功能训练评估系统（AL-600型）对受试对象进行步态测试,经分析评估软件提取各步态时空参数（站立期时间、摆动期时间、步长及步宽）,其步态时空参数的不对称性评估用双侧下肢步长不对称比（SLA）、摆动期时间不对称比（SWTA）和站立期时间不对称比（STA）表示。并对30例脑卒中患者进行Berg平衡量表(BBS)评分。用两独立样本t检验分析病例组与对照组的各时空参数不对称比（SLA、SWTA、STA）及步宽的差异,用Pearson相关性分析法分析SLA、SWTA和STA分别与步宽及BBS评分之间的相关程度。 结果病例组患者步行时,患侧的步长及摆动期时间均较健侧增加(P<0.05),患侧站立期时间较健侧缩短（P<0.05）;而对照组下肢步态分析,各时空参数左右侧之间差异无统计学意义（P&rt;0.05）。病例组患者的步宽及各时空参数不对称比（SLA、SWTA和STA）的比值均较对照组增大（P<0.01）。病例组患者的步宽［(15.90±2.60）cm］与BBS评分［（41.57±7.27）分］之间呈中度负相关（r=-0.564,P<0.01）,而患者的SLA与步宽呈轻度正相关（r=0.432,P<0.05）,与BBS评分呈高度负相关（r=-0.849,P<0.01）;患者SWTA与步宽呈高度正相关（r=0.726,P<0.01）,与BBS评分呈中度负相关（r=-0.630,P<0.01）;患者STA与步宽和BBS评分之间均未见明显相关性（r=0.352,r=-0.126,P&rt;0.05）。 结论脑卒中偏瘫患者步态时空参数存在不对称性,其步态的不对称程度与平衡功能之间存在一定的相关性。     

运动对老年高血压病患者血流动力学和心血管体液因子的影响

目的探讨运动对老年高血压病患者血流动力学和心血管体液因子的影响.方法高血压组为2～3级老年原发性高血压患者34例(药物控制),正常老年对照组31例,作自感劳累分级法(RPE)11～13级疲劳程度的症状限制性运动平板试验(改良的Bruce方案),试验前3 min、后3 min抽静脉血检测,观察运动过程的心率、血压、运动当量、运动时间及运动前、后的一氧化氮(NO)、内皮素(ET1)、血管紧张素Ⅱ (AngⅡ)、心房肽(ANF). 结果高血压组与对照组比较,平板运动前、运动峰时、恢复期3 min的心率、收缩压、舒张压及总的运动时间、峰时的运动当量,均P>0.05,差异无显著性意义;运动后高血压组NO上升48.7%,对照组上升52.0%,均P<0.05,差异有显著性意义;高血压组ANF运动前比对照组高 22.0%,P=0.006;2组运动前、后差值比较,NO、ET1、AngⅡ、ANF均P>0.05.运动前收缩压与运动峰时、运动后收缩压正相关(r=0.648, 0.630,P<0.001);运动前舒张压与运动峰时、运动后舒张压呈正相关 (r=0.359,0.520, P<0.001);年龄与平板运动当量呈负相关(r=0.655,P<0.001). 结论老年高血压患者在药物控制下参加轻度疲劳程度的运动(相当于8运动当量)过程中,其心率、血压的升高与正常对照组相似;血液中NO的变化有益于高血压病的治疗,短时间内未见ET1、AngⅡ和ANF水平的明显改变.     

正常人动态平衡能力测试的信度及效度分析

目的　对正常人平衡功能进行动态姿势图重复检测 ,分析各参数间的内在一致性、重测信度及不同测试者间的信度 ;并与Berg平衡量表、功能性前伸测量、起立行走计时测定结果比较 ,检验其效标效度。方法　 2名测试者应用BiodexBalanceSystem (BBS)分别对 40名正常受试者 ( 18～ 67岁 )进行 2次 8级平台稳定性动态姿势图测试及稳定性测试 ;同时还应用Berg平衡量表、功能性前伸距离及起立行走计时等方法进行检测。结果　研究结果发现年龄因素对所有检测参数均有影响 ,体重指数对稳定指数及平均方向控制能力有影响。各参数间内部存在一致性 (r =0 .2 2～ 0 .93 ,均P <0 .0 1) ,其重测信度 (r =0 .70～ 0 .99)及不同测试者间信度 (r =0 .71～ 0 .98)较佳 (ICC =0 .88～ 0 .99)。在测试过程中 ,发现不同跌下次数的受试者其年龄差异和测试结果间差异显著相关 (P <0 .0 0 1)。BBS测试数据与Berg平衡量表、功能性前伸测量、起立行走计时测评结果有较高的相关性 (r =0 .72～ 0 .86)。结论　BBS能反映受试者平衡能力的年龄变化趋势 ,具有较高的内在一致性、重测信度及不同测试者间的信度 ,与Berg平衡量表、起立行走计时及功能性前伸测量结果具有一致性 ,可用于平衡功能的定量评定。     

Determination of Biodex Balance System Cutoff Scores in Older People With Nonspecific Back Pain: A Cross-sectional Study

ObjectiveThe purpose of this study was to determine cutoff scores for the Biodex Balance System (BBS) and verify if they could be used to discriminate older people with nonspecific low back pain (NSLBP) with poor postural performance from those with good postural performance.MethodsThis cross-sectional study included 52 participants with NSLBP older than 65 years. One level of stability (level 5; intraclass correlation ≥0.70) and 2 conditions (eyes open and eyes closed) were selected for the testing procedure. Anterior-posterior stability index (APSI), medial-lateral stability index (MLSI), and overall stability index (OSI) scores were calculated. The participants were classified into 2 groups: high risk of falling and low risk of falling. Both the receiver operating characteristic and the area under the curve were used to determine the best BBS cutoff values. Binary logistic regression analysis was used to investigate the ability of BBS scores to predict risk of falling.ResultsBBS cutoff scores in the eyes-open condition (APSI = 2.60, MLSI = 1.95, OSI = 2.95) and eyes-closed condition (APSI = 3.05, MLSI = 2.17, OSI = 3.25) were found to be sensitive and specific in determining postural performance. Participants with index values lower than the cutoff scores had, respectively, 6.42, 4.20, and 3.72 times lower risk of falling in the eyes-open condition and 3.33, 5.50, and 3.00 times lower risk of falling in the eyes-closed condition. The predictive characteristics of the models for risk analysis were excellent and good to excellent.ConclusionOur study shows that BBS cutoff scores are sensitive and specific in distinguishing between poor and good postural performance in older people with NSLBP.     

Effects of an Exercise Program Using Aero-step Equipment on the Balance Ability of Normal Adults

[Purpose] This study was conducted to investigate the effects of an exercise program using aero-step exercise equipment on the balance ability of normal adults. [Subjects] Twenty-one normal adults were randomized into a flat floor exercise program group (FEG, n = 7), an aero-step exercise program group (AEG, n = 7), and a control group (CG, n = 7). [Methods] the FEG and AEG performed an exercise program four times a week for 2 weeks, but CG did not receive any treatment. The overall stability index (OSI), anterioposterior stability index (APSI), and mediolateral stability index (MLSI) were measured and compared using a Biodex balance system. [Results] The intragroup comparison revealed significant differences in OSI and APSI of AEG and in MLSI of FEG. [Conclusion] The exercise program using aero-step equipment seems to be effective at improving the balance abilities of OSI and APSI.Key words: Aero-step, Balance ability, Stability     

Effects of Indoor Horseback Riding and Virtual Reality Exercises on the Dynamic Balance Ability of Normal Healthy Adults

[Purpose] The objective of this study was to determine the effect of indoor horseback riding and virtual reality exercises on the dynamic balance ability of normal adults. [Subjects] This study enrolled 24 normal adults and divided them into two groups: an indoor horseback riding exercise group (IHREG, n = 12) and a virtual reality exercise group (VREG, n = 12). [Methods] IHREG exercised on indoor horseback riding equipment and VREG exercised using the Nintendo Wii Fit three times a week for six weeks. The Biodex Balance System was used to analyze dynamic balance as measured by the overall stability index (OSI), anteroposterior stability index (APSI), and mediolateral stability index (MLSI). [Results] In the within-group comparison, IHREG and VERG both showed significant decreases in the dynamic balance indexes of OSI, APSI, and MLSI after the intervention, but no significant difference was found between the groups. [Conclusion] Both indoor horseback riding and virtual reality exercises were effective at improving the subjects’ dynamic balance ability as measured by OSI, APSI, and MLSI, and can be used as additional exercises for patients with conditions affecting postural control.     

脑卒中偏瘫患者静态和动态平衡评定的研究

目的探讨脑卒中偏瘫患者实验室定量测定的静态平衡与临床评定的动态平衡之间的相互关系,并探讨两者在脑卒中偏瘫患者功能结局评定中的价值.方法对19例患者用重心摆动测定法评定静态平衡;用Berg平衡量表(BBS)和起立-行走计时测试(TUGT)评定动态平衡;用功能独立性测量(FIM)和10m最大步行速度评测(MWS)来评定功能结局.用Pearson相关分析法确定静态平衡与动态平衡之间的关系,确定静态和动态平衡评定与功能结局之间的关系.结果重心摆动测定参数与BBS之间呈中度负相关(r=-0.705--0.475,P<0.05);闭眼重心摆动测定参数与TUGT之间呈中度的正相关(r=0.508-0.583,P<0.05).重心摆动测定参数与FIM-A和MWS之间无相关性(r=-0.048--0.296;r=-0.404--0.01,P>0.05),BBS与FIM-A和MWS之间呈高度的正相关(r=0.752;r=0.700,P<0.001),TUGT与FIM-A和MWS之间呈高度的负相关(r=-0.600,P<0.01;r=-0.817,P<0.001).结论在实验室中测定的静态平衡结果与在临床上评定的动态平衡结果是相关联的,但是动态平衡评定比静态平衡评定更能有效地反映脑卒中患者的功能结局.     

两种平衡量表在脑卒中患者平衡功能评定的实用性研究

目的探讨Berg平衡功能评定表(BBS)和Fugl-Meyer平衡功能评定表(FM-B)在脑卒中患者平衡功能评定的临床实用性及相关性。方法对68例脑卒中患者，于平衡功能训练前后分别应用BBS和FM-B由专人进行评定，然后对每位患者进行静态姿势平衡测试仪(BPM)测试。BPM测试分别在睁眼和闭眼状态下进行，取摆幅指数(SI)、摆动的轨迹长(ing)、外周面积(area)进行分析。结果治疗前后比较，FM-B评定无显著性差异(P＞O．05)；BBS评定和BPM各检测指标均有非常高度显著性差异(P＜O．001)；FM-B与BBS之间呈中度的正相关(r=O．517，P＜O．001)，FM-B与BPM各观察指标之间无相关性(r=-O．074～-O．247，P＞O．05)；BBS与BPM各观察指标之间呈中度负相关(r=-O．410～-O．587，P＜O．01～O．001)。结论BBS与BPM在评定脑卒中患者平衡功能方面具有良好的一致性，都可以反映患者的平衡状态；但FM-B对治疗前后的效果评定敏感性较差，其临床实用性较低。     

Postural stability in patients with ankylosing spondylitis

Purpose.?The aim of this study is to determine whether the postural changes in ankylosing spondylitis (AS) affected postural stability.

Method.?A total of 64 patients with a diagnosis of AS and 50 healthy volunteers were included in the study. The patients were divided into two groups according to a tragus-to-wall distance?<15?cm (Group I, n?=?30) and?≥15?cm (Group II, n?=?34). The control group (Group III) consisted of 50 healthy volunteers. The postural stability was evaluated with the Biodex Stability System (BSS). The results of Antero-Posterior Stability Index (APSI), Medio-Lateral Stability Index (MLSI) and Overall Stability Index (OSI) were evaluated.

Results.?There were statistically significant differences between the three groups for OSI, APSI and MLSI. MLSI results were significantly different among patient groups. When Group II and the control group were compared, there were significant differences for OSI, APSI, and MLSI. Comparing Group I with the control group revealed a more significant difference for OSI, APSI, and MLSI.

Conclusions.?We have found that postural stability decreases in patients with AS in both the early and the late stages of the disease, but especially in the latter ones. This result may be thought to be related with increased kyphosis which is seen during the course of the disease.     

Influence of Isokinetic Strength Training of Unilateral Ankle on Ipsilateral One-legged Standing Balance of Adults

[Purpose] The purpose of the current study was to investigate the changes in one-legged standing balance of the ipsilateral lower limb following unilateral isokinetic strength training. [Subjects and Methods] Thirty healthy adult volunteers were randomly assigned to either a training group or a control group, so that each group included 15 subjects. Subjects in the training group performed unilateral ankle isokinetic exercises of the dominant leg using the Biodex 3 PRO System for a period of four weeks. Ipsilateral one-legged standing balance was evaluated before and after the intervention with three stability indexes of balance using the Biodex System: Anterior-Posterior Stability Index (APSI), Medial-Lateral Stability Index (MLSI), and Overall Stability Index (OSI). [Results] Comparison of pre- and post-test data revealed significant improvements in strength values (dorsiflexion, plantarflexion, eversion, and inversion) and stability indexes (APSI, MLSI, OSI). [Conclusion] These results suggest that ankle strengthening exercise can be considered as a form of exercise that may assist individuals with improvement of balance.Key words: Postural balance, Isokinetic exercise, Strength training     

阻塞性睡眠呼吸暂停低通气综合征患者亚临床右心室功能障碍的肺动脉硬化度

目的:研究阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者发生亚临床的右心室功能障碍时其肺动脉硬化度(PAS)的变化.方法:实验组选取的是经多导睡眠监测仪(PSG)确诊的80例OSAHS患者,根据AHI的不同分成3组,对照组选取的是同一时间段的35例健康者.使用二维超声收集所需常规超声参数,使用速度向量成像(VVI)技...     

Urinary C-peptide as a measure of beta-cell function after a mixed meal in healthy subjects: comparison of four-hour urine C-peptide with serum insulin and plasma C-peptide

Urinary C-peptide (UCP) is a noninvasive measure of integrated insulin production, and the usefulness of 24-h collections has been previously reported. Only small numbers of subjects have been studied using shorter urine collections. To see how well 4-h urine collections for C-peptide (UCP) correlate with serum immunoreactive insulin (SI) and plasma C-peptide (PCP), we studied 41 healthy subjects (19 men, 22 women) using as a stimulus a 600-kcal mixed meal and the same mixed meal after oral prednisone. UCP values correlated best with the area under the curves for SI (r = 0.457, P less than 0.001) and PCP (r = 0.557, P less than 0.001). UCP was also significantly correlated with peak SI (r = 0.382, P less than 0.001), peak PCP (r = 0.496, P less than 0.001), fasting SI (r = 0.297, P = 0.007), and fasting PCP (r = 0.341, P = 0.007) values. Urinary C-peptide was significantly correlated with SI and PCP concentrations in a broad range of physiologic values for SI and PCP supporting the usefulness of UCP as a simple, noninvasive measure of beta-cell function. Four-hour collections for UCP may be useful in further studies of beta-cell function.