无声的世界温情的服务

一天晚上,店里来了一位“神秘”顾客,她面无表情在店里转了好几圈,谁招呼她,她都不理.“难道是来暗访的？但是怎么看也不像呀.”大家悄悄议论着.     

感冒清热颗粒的的质量标准

目的：制定感冒清热颗粒质量标准。方法：采用TLC法对方中柴胡、葛根、防风、苦地丁进行定性鉴别；采用HPLC法对颗粒中的葛根素进行含量测定。结果：本品薄层色谱特征明显，葛根素平均回收率为100．1％；RSD为0．9％（n=6）。结论：该方法简便、准确，可控制感冒清热颗粒的质量。     

看得见的与看不见的

我有时也与一些投资公司聊天,他们一般会问三个标准问题。问题一：网上卖药对实体药店有没有影响？答：当然有影响,尤其是安全套、家用医疗器械。经过类别分析,实体店里药食同源类商品增长较快,处方药与OTC有一定增长,而安全套与器械类没有增长,保健品似乎是负增长。这显然是网上药店的冲击所致。     

平凡的岗位 默默的奉献

举世瞩目的2010上海世博会于2010年5月1日正式拉开帷幕,此次世博会历时184天,是由中国举办的首届世界博览会,参观人数创下了世博会历史上的最高纪录,同时也给世博食品安全保障提出了新的挑战和严峻的考验。     

企业的铁腕 店员的朋友

高素平,常州恒泰奥园人民大药房店长。2013年5月,她调入这个大店,前任店长因身体原因已经一个多月没来店里,接收时门店管理非常混乱,月完成率下滑到只有80%,对于一个年营业额过千万的店来说,这意味着什么？高素平开始紧锣密鼓地整顿,大到商品结构、库存控制,     

你的偏头痛是怎样的

偏头痛是一种周期性发作的神经一血管功能障碍引起的头痛,常有家族史.以反复发作的一侧或两侧搏动性头痛为特征,为临床常见的特发性头痛.     

光荣的事业 无悔的选择

微笑是最美丽的表情,真诚是联系人与人之间最真挚的纽带,爱是人类最伟大的情感.作为一名药师,在与病人最真诚的交流中,给予病人的是发自内心的爱,全身心投入的爱,无私奉献的爱.我是一名药师,是一名体会着爱与被爱的幸福与温暖的药师.     

海的味道 山的味道

对于一个正宗吃货来说,"海的味道、山的味道"一定是不陌生的,读过《窗边的小豆豆》这本书的美食爱好者们印象应该更深刻。巴学园的校长要求孩子们带来的盒饭里要有海的味道和山的味道。山的味道,比如说蔬菜啦,肉啦(当然,肉并不是在山上得到的,但是大致区分一下的话,牛啊猪啊鸡啊都是生长在陆地上的,就归人"山的味道"里面);海的味道则是鱼啦,红烧海味什么的。总之,校长大人没     

崭新的起点 崭新的征程

正西方哲学家赫拉克利特说:人不能两次踏进同一条河流。对于新时代健康产业集团而言,每一天都是一个崭新的起点,对于新时代人而言,每一天都被美好明天的憧憬所振奋。新时代人在扎根现实、立足市场的同时,常怀感恩之心,常思奋起之志,以17年发展的累累硕果为崭新的起点,开辟全新的征程。今天的新时代人已经开启了健康产业发展的新时代,新时代人正准备进入与人体健康有关的更广阔的新领域,满足新时期大时代背景下社会民众的健康需求。广大新时代人在大健康产业格局远景     

光荣的事业无悔的选择

法国文学家雨果在他的诗里曾经写到:"花是尊贵的,果实是甜美的,让我们都来做叶吧,因为叶,是平凡而谦逊的."我觉得这首诗就是为我们药师写的,因为药师就像那默默奉献的绿叶,时时刻刻衬托着鲜花的娇艳.     

Effects of cannabidiol and of diphenylhydantoin on the hippocampus and on learning

Cannabidiol (3.5 mg/kg, i.p.) depressed hippocampal facilitation and posttetanic potentiation of evoked responses in rats, such, as had been reported before for diphenylhydantoin. Both diphenylhydantoin (80 mg/kg, i.p.) and cannabidiol blocked the increase of hippocampal RNA concentration caused by afferent stimulation, and depressed the acquisition of a conditioned avoidance response in rats. Neither drug affected the retention of such response when given by posttrial injection, nor the spontaneous locomotor activity of mice. The effects of both agents may be explained by the interference they have been previously shown to produce with the release of K⁺ from the hippocampus during stimulation. In fact, hippocampal facilitation and posttetanic potentiation and the RNA response to stimulation have been shown to be phenomena which depend on this K⁺ release, and have been attributed a role in learning.     

β3-肾上腺素受体激动剂的研究进展

摘要β     

妊娠合并子宫肌瘤对母儿影响的分析

目的 探讨妊娠合并子宫肌瘤对母儿的影响。方法 对1999年1月～2004年12月73例在剖宫产术中发现的子宫肌瘤进行分析。结果 妊娠合并肌瘤的胎位异常（臂位）率、产后出血率分别为17．8％、20．54％,而对照组分别为3．18％和8．97％;低体重儿发生率12、33％,而对照组为6．07％,有显著差异。结论 子宫肌瘤增加了母儿并发症的可能性;合并黏膜下肌瘤也有望使妊娠过程成功。     

朱砂及含朱砂制剂的肝肾毒性研究

目的 探讨朱砂、含朱砂制剂（柏子养心片）及甲基汞对大鼠的体内外毒性,为其临床安全用药提供科学依据。方法 ①对比甲基汞、朱砂及柏子养心片体外对人肝HL-7702细胞和人肾近曲小管上皮HK2细胞的毒性,计算半数抑制浓度（IC₅₀）。②SD大鼠随机分为对照组,朱砂组0.1 g/kg,柏子养心片0.2、0.4、0.8 g/kg组,甲基汞组0.001 g/kg,每天ig 1次,连续给药90 d后,取血及肝、肾组织;试剂盒法检测血清中丙氨酸转氨酶（ALT）、天冬氨酸转氨酶（AST）、肌酐（CREA）、尿素氮（BUN）水平,测汞仪固体直接进样法检测肝、肾组织中汞蓄积量,并对大鼠肝脏和肾脏做组织病理学检查。结果 体外试验表明,朱砂、柏子养心片及甲基汞对HL-7702细胞的IC₅₀分别为7.852、6.035、0.009 5 g/L;对HK2细胞的IC₅₀分别为6.297、4.484、0.008 9 g/L。亚慢性毒性试验表明,甲基汞组大鼠肝、肾组织中汞蓄积量及血清中ALT、AST、CREA、BUN值均显著高于对照组,而朱砂及柏子养心片（高、中、低剂量）组与对照组比较均没有显著性差异;甲基汞组大鼠肝脏呈现肝细胞变性,肾脏可见明显肾小管损伤,而朱砂及柏子养心片（高、中、低剂量）组与对照比较没有明显差异。结论 朱砂及柏子养心片的体内外毒性均显著低于甲基汞,在目前药典规定的临床用量下使用安全性较好。     

Effects of raunescine and isoraunescine on behaviour and on the 5-hydroxytryptamine and noradrenaline contents of brain

Some behavioural effects of raunescine and isoraunescine on pigeons have been studied; no qualitative difference was detected between their effects and those of reserpine. Isoraunescine is between five and ten times less potent than raunescine, which, in turn, is much less potent than reserpine in producing these effects.

Both raunescine (5 mg./kg.) and isoraunescine (50 mg./kg.) were found to cause a reduction in the concentration of noradrenaline in the brains of rats. Raunescine (5 mg./kg.) also caused a reduction in the concentration of 5-hydroxytryptamine in brain; isoraunescine did not do so in the same dose; higher dose levels were not studied.

     

Effect of ranitidine on ileal myenteric plexus preparation and on acetyl- and butyrylcholinesterase

Ranitidine at concentrations from 1 microM to 0.1 mM brought about a dose-dependent potentiation of the twitch responses elicited by electrical stimulation of the ileal myenteric preparation. At higher concentrations (0.3-3 mM) ranitidine also caused irregular slow contractions of the unstimulated ileal preparation which were potentiated by eserine and blocked by atropine and tetrodotoxin. In order to identify the mechanism of these apparently cholinomimetic actions, the effects of ranitidine on AChE and BuChE were studied. Ranitidine showed an instantaneous and promptly reversible inhibitory action at concentrations between 0.5 and 30 microM. Double reciprocal plots were prepared and equilibrium dissociation constants calculated. It appears that ranitidine exerts an inhibition of the "mixed" type on both AChE and BuChE, but the dissociation constants for BuChE were markedly higher than those for AChE. Since AChE inhibition occurs in the same concentration range potentiating the twitch responses on the ileal myenteric preparation, it may explain the cholinomimetic effect of ranitidine.     

Effect of sodium diclofenac on serum and tissue concentration of amoxicillin and on staphylococcal infection

The effect of sodium diclofenac on serum and tissue amoxicillin concentration as well as their effect against staphylococcal infection was observed. Four polyurethane sponges were placed in the back of thirty rats. After 14 d, two granulomatous tissues received 0.5 ml of 10(8) cfu/ml (Staphylococcus aureus). Two days later, the rats were divided into five groups: group 1 received amoxicillin 50 mg/kg/p.o., group 2 received amoxicillin 25 mg/kg/p.o., group 3 received sodium diclofenac 2.5 mg/kg/i.m. and amoxicillin 50 mg/kg/p.o., group 4 received sodium diclofenac 2.5 mg/kg/i.m., and group 5 (control group) received NaCl 1 ml/p.o. After six hours of drug administration, blood serum (10 microl) and noninfected granulomatous tissues were placed on Mueller-Hinton agar inoculated with 10(8) cfu/ml (S. aureus). Infected tissues were dispersed in a sonic system and were spread (10 microl) on salt mannitol agar. Microorganisms were counted and the inhibition zones were measured after 18 h of incubation at 37 degrees C. Amoxicillin tissue concentration was 6.27 microg/g for group 1, 2.18 microg/g for group 2, and 0.72 microg/g for group 3. The serum concentrations were 11.56 microg/ml for group 1, 5.36 microg/ml for group 2, and 1.34 microg/ml for group 3. No differences were observed among group 1, 2, and 3 regarding staphylococci counts (Kruskall-Wallis test p>0.05). Group 4 reduced (p<0.05) staphylococci counts comparing to group 5. It was concluded that sodium diclofenac reduced serum and tissue amoxicillin concentration and, even in large doses, amoxicillin was not effective in eradicating the staphylococcal infection after 6 h of administration.     

Effects of H-Phe-Ile-Tyr-His-Ser-Tyr-Lys-OH on passive and active avoidance behavior and on open-field activity of rats

The action of H-Phe-Ile-Tyr-His-Ser-Tyr-Lys-OH on the passive and active avoidance behavior and open-field activity of rats was studied after peripheral and intracerebroventricular administration. When applied before the test session, intracerebroventricular administration increased the avoidance latency of passive avoidance behavior. Subcutaneous, intraperitoneal and intracerebroventricular administration of the peptide delayed the extinction of active avoidance behavior. Both subcutaneous and intracerebroventricula administration increased the grooming activity of the rats. The data suggest that H-Phe-Ile-Try-His-Ser-Tyr-Lys-OH is able to influence memory, acting mainly on the retrieval processes, ad to modify open-field activity.     

高血糖、高胰岛素对内皮细胞凋亡及Mn-SOD表达的研究

目的：了解糖尿病高胰岛素及高血糖的改变对内皮细胞凋亡及Mn-SOD表达的影响。方法：在高糖、高胰岛素及对照培养环境,分别孵育内皮细胞72h测定细胞凋亡情况并检测Mn-SOD的表达水平。结果：内皮细胞在高糖、高胰岛素条件下凋亡显著增加（P〈0.05）,同时Mn-SOD表达下降（P〈0.05）。结论：在高胰岛素血症而血糖没有升高到糖尿病标准的阶段,就会有内皮细胞凋亡显著增加,从而促进动脉粥样硬化形成,同时还有Mn-SOD表达水平的下降,病损持续存在于2型糖尿病进展的各个阶段。     

Influence of streptozotocin-induced diabetes on blood pressure and on renin formation and release

Summary I.v. injection of 40 mg/kg or 65 mg/kg streptozotocin reliably induced diabetes in female Sprague-Dawley rats, but failed to induce hypertension within the following 42 days. In most animals injected with the higher dose and in some animals injected with the lower dose, the tail blood flow was permanently impaired so that no blood pressure signals could be obtained by tail plethysmography. This phenomenon occurred also when the drug was injected into the jugular vein and thus was not due to a local effect of streptozotocin. 15 days after 65 mg/kg streptozotocin, the mean arterial pressure of the rats was similar to that of controls, when measured in the awake state (carotid cannula) or under ether anaesthesia. 42 days after streptozotocin, under pentobarbital anaesthesia, the blood pressure was again normal in the animals given 40 mg/kg of the drug and depressed in the animals given 65 mg/kg of the drug 42 days previously. The increase of blood pressure induced by 1 g/kg (–)-noradrenaline i.v. was similar in the latter group of animals and in controls.The renal cortical renin concentration was much lower than in controls 42 days after either dose of streptozotocin, while the plasma renin activity was normal (40 mg/kg) or increased (65 mg/kg). The low renal renin content may have been due to the diabetic state, rather than to the drug itself. Adrenal medullary dopamine-beta-hydroxylase activity was increased 42 days after the higher dose of streptozotocin.Supported by the Swiss National Science Foundation, grant Nr. 3.410.078