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高血糖与胆石症40例临床报告 总被引:10,自引:0,他引:10
目的 分析胆石症和糖尿病发病率之间的关系。讨论糖尿病合并无症状胆石症时是应该手术治疗以及糖尿病病人胆道手术的围手术期处理。方法 对40例合并高血糖的胆石症病人进行回顾性分析。结果 外科胆石症 693例,其中40例合并高血糖。男性14例,女性26例,平均年龄60.1岁。确认糖尿病15例,可疑糖尿病11例,应激性高血糖14例。手术治疗33例,胆囊切除14例,胆囊切除、胆总管探查16例,胆肠内引流2例, 相似文献
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E. Ferrannini M. Massari M. Nannipieri A. Natali R. Lopez Ridaura C. Gonzales-Villalpando 《Diabetologia》2009,52(5):818-824
Aims/hypothesis The value of diagnostic categories of glucose intolerance for predicting type 2 diabetes is much debated. We therefore sought
to estimate relative and population-attributable risk of different definitions based on fasting (impaired fasting glucose
[IFG]) or 2 h plasma glucose concentrations (impaired glucose tolerance [IGT]) and to describe the associated clinical phenotypes.
Methods We prospectively observed a population-based cohort of 1,963 non-diabetic participants (mean age 47 years), in whom an OGTT
was performed at baseline and 7 years later.
Results IGT was fivefold more prevalent (13.5%) than IFG. In both categories, participants were older, heavier, hyperinsulinaemic,
hyperproinsulinaemic and dyslipidaemic compared with participants with normal glucose tolerance. Relative risk of incident
diabetes was similar for IFG and IGT categories (3.73 [95% CI: 2.18–6.39] and 4.01 [95% CI: 3.12–5.14], respectively), but
the population-attributable risk was fivefold higher for IGT (29% [95% CI: 26–32]) than for IFG (6% [95% CI: 5–7]). Isolated
IFG carried no increase in risk. Lowering the threshold to 5.6 mmol/l raised the population-attributable risk of IFG to 23%
(95% CI: 20–25); its contribution to diabetes progression, however, was largely due to co-existent IGT. In multivariate analysis
adjusting for sex, age, familial diabetes and BMI, fasting and 2 h glucose were independent predictors.
Conclusions/interpretation Fasting and 2 h glucose values are independent predictors of incident diabetes. Isolated IFG is not a high-risk condition;
lowering the diagnostic threshold increases the population-attributable risk of IFG fourfold, but performing an OGTT captures
additional diabetes progressors compared with the number identified by IFG. 相似文献
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目的探讨1型糖尿病(T1DM)患者心理痛苦的现状及其影响因素。方法选取2019年8月至2020年1月于南京大学医学院附属鼓楼医院治疗的199例T1DM患者,当面向患者发放一般资料调查问卷、T1DM痛苦量表、医学应对方式问卷和领悟社会支持量表进行问卷调查。采用Pearson相关分析法分析T1DM患者心理痛苦得分与应对方式及社会支持的相关性。采用logistic多元线性回归分析法分析T1DM患者心理痛苦的影响因素。结果199例T1DM患者中伴有糖尿病痛苦者173例,检出率为88.44%。T1DM患者心理痛苦总得分为(2.15±0.61)分。T1DM患者心理痛苦得分与面对、回避应对方式、家庭支持、朋友支持维度均呈负相关(r=-0.867~-0.407,均P<0.01),与屈服应对方式均呈正相关(r=0.407~0.749,P<0.01),与其他支持维度无相关性(均P>0.05)。多元线性回归分析结果显示:T1DM痛苦总分与共同居住人数(β=-0.116),并发症(β=0.091),严重低血糖事件(β=0.061),采取面对、回避、屈服应对方式(β=-0.118、-0.177、0.116)、家庭支持(β=-0.363)和朋友支持得分(β=-0.171)有关(均P<0.05)。结论T1DM患者的心理痛苦处于中等水平,其影响因素有居住状态、糖尿病并发症、近期严重低血糖事件、疾病应对方式和社会支持。 相似文献
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Deepak Gahlan Rajesh Rajput Pratibha Gehlawat Rajiv Gupta 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(3):333-336
Background
Patients of diabetes mellitus experience psychological difficulties associated with their disease which remains unrecognized involving several states related to coping with diabetes. Diabetes distress is a distinct condition which is often mistaken for depression and is related to adverse disease outcomes.Aims and objective
To study the prevalence and predictors of diabetes distress in patients of Type 2 Diabetes mellitus (T2DM) in a tertiary care centre.Materials and methods
This cross-sectional study was conducted over a period of one year at Endocrine OPD of Pt. B.D. Sharma PGIMS, Rohtak, a tertiary care centre in northern India. 410 consecutive patients having T2DM attending the endocrine OPD were screened for psychiatric disorders and 189 diabetic patients with no underlying psychiatric disorders were included in the study. Their socio-demographic and relevant clinical variables were recorded. Diabetes Distress Scale (DDS) was used to measure distress due to the disease in these patients.Results
It was found that the prevalence of diabetes distress was 18.0%; among them 16.1% had emotion related distress, 5.6% regimen related distress, 1.5% interpersonal related distress and 1.2% physician related diabetes distress. The major predictors for high diabetes distress scores among diabetic cases were low education level, retinopathy, neuropathy and hypertension.Conclusion
The present study suggests that emotion related diabetes distress was more prevalent among diabetic patients. Lower education level and the presence of diabetic complications contribute as risk factors for high diabetes distress. 相似文献8.
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Urinary ethanol and diabetes mellitus 总被引:2,自引:0,他引:2
Ethanol concentrations were assayed in urine samples obtained from 10 newly presenting diabetic patients (aged 50-69 years) with glycosuria and symptoms suggesting genito-urinary candidiasis. No alcohol was detected initially with diabetic urine samples, but when stored at room temperature 8 out of 10 samples showed increasing levels of ethanol from day 3 to day 20. Peak levels were more than 10,000 mg/l in three samples and more than 1500 mg/l in six samples. Studies were also performed using normal urine and urine to which was added glucose and/or Candida. Samples were kept at either room temperature or 4 degrees C for up to 21 days and ethanol assays performed at regular intervals. Studies with non-diabetic urine showed a maximum ethanol level of 500 mg/l after 11 days only in samples containing both glucose and Candida and kept at room temperature. 相似文献
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Caspase与糖尿病 总被引:4,自引:0,他引:4
Caspase是一组具有相似氨基酸序列、空间结构和底物特异性的半胱氨酸蛋白酶,由其引发的级联反应是细胞凋亡过程中的中心环节。1型、2型糖尿病均以胰岛β细胞凋亡为特征。T淋巴细胞,尤其是CD4 辅助性T细胞通过分泌干扰素-γ、肿瘤坏死因子-α、白细胞介素-1β等细胞因子激活cas-pase,介导了胰岛β细胞凋亡和1型糖尿病的发生。在2型糖尿病中,胰岛淀粉样变、高血糖、高游离脂肪酸等也可通过激活caspase导致β细胞凋亡。Caspase参与了1型、2型糖尿病的发生、发展。 相似文献
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糖尿病是一种由遗传因素和环境因素共同作用引起的慢性代谢性疾病,其发病与生活方式关系密切.本文就饮食、睡眠、吸烟、运动等生活方式对糖尿病发病的影响及其干预和遗传的交互作用进行综述.Abstract: Diabetes mellitus is a chronic metabolic disease caused by both genetic and environmental factors, it has a significant association with lifestyle. This paper mainly discusses the effects of diet, sleep, smoking,physical exercise, and lifestyle intervention that interact with genetics on diabetes. 相似文献
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糖尿病是严重威胁人类健康的代谢紊乱性疾病.干细胞具有自我更新和多向分化潜能.来源于成体干细胞和胚胎干细胞的胰岛细胞移植也许是有前途的糖尿病治疗方法.干细胞体外培养时可以自发或诱导分化为胰岛素分泌细胞,部分实验证实移植后的胰岛素分泌细胞可以纠正糖尿病小鼠的高血糖状态,这一研究为糖尿病细胞替代治疗带来希望. 相似文献
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糖尿病是严重威胁人类健康的代谢紊乱性疾病.干细胞具有自我更新和多向分化潜能.来源于成体干细胞和胚胎干细胞的胰岛细胞移植也许是有前途的糖尿病治疗方法.干细胞体外培养时可以自发或诱导分化为胰岛素分泌细胞,部分实验证实移植后的胰岛素分泌细胞可以纠正糖尿病小鼠的高血糖状态,这一研究为糖尿病细胞替代治疗带来希望. 相似文献
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糖尿病是严重威胁人类健康的代谢紊乱性疾病.干细胞具有自我更新和多向分化潜能.来源于成体干细胞和胚胎干细胞的胰岛细胞移植也许是有前途的糖尿病治疗方法.干细胞体外培养时可以自发或诱导分化为胰岛素分泌细胞,部分实验证实移植后的胰岛素分泌细胞可以纠正糖尿病小鼠的高血糖状态,这一研究为糖尿病细胞替代治疗带来希望. 相似文献
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糖尿病是严重威胁人类健康的代谢紊乱性疾病.干细胞具有自我更新和多向分化潜能.来源于成体干细胞和胚胎干细胞的胰岛细胞移植也许是有前途的糖尿病治疗方法.干细胞体外培养时可以自发或诱导分化为胰岛素分泌细胞,部分实验证实移植后的胰岛素分泌细胞可以纠正糖尿病小鼠的高血糖状态,这一研究为糖尿病细胞替代治疗带来希望. 相似文献
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糖尿病是严重威胁人类健康的代谢紊乱性疾病.干细胞具有自我更新和多向分化潜能.来源于成体干细胞和胚胎干细胞的胰岛细胞移植也许是有前途的糖尿病治疗方法.干细胞体外培养时可以自发或诱导分化为胰岛素分泌细胞,部分实验证实移植后的胰岛素分泌细胞可以纠正糖尿病小鼠的高血糖状态,这一研究为糖尿病细胞替代治疗带来希望. 相似文献
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糖尿病是严重威胁人类健康的代谢紊乱性疾病.干细胞具有自我更新和多向分化潜能.来源于成体干细胞和胚胎干细胞的胰岛细胞移植也许是有前途的糖尿病治疗方法.干细胞体外培养时可以自发或诱导分化为胰岛素分泌细胞,部分实验证实移植后的胰岛素分泌细胞可以纠正糖尿病小鼠的高血糖状态,这一研究为糖尿病细胞替代治疗带来希望. 相似文献
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调节性T淋巴细胞与桥本甲状腺炎 总被引:1,自引:0,他引:1
调节性T细胞抑制CD4 + T细胞或CD8+ T细胞的活化和增殖 ,在免疫应答中发挥重要的负调节作用 ,是维持自身免疫耐受的主要细胞之一。桥本甲状腺炎为遗传因素和多种内外环境因素影响的自身免疫性疾病。大量研究表明 ,调节性T细胞异常表达参与桥本甲状腺炎的发病。毒性T细胞相关抗原 4、CD2 8/B7协同刺激通路、粒细胞集落刺激因子、某些细胞因子等通过影响调节性T细胞的负调节作用而参与桥本甲状腺炎的发病。对调节性T细胞的深入研究有利于进一步阐明桥本甲状腺炎的发病机制并为桥本甲状腺炎的治疗提供新的方法。 相似文献
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糖尿病是严重威胁人类健康的代谢紊乱性疾病.干细胞具有自我更新和多向分化潜能.来源于成体干细胞和胚胎干细胞的胰岛细胞移植也许是有前途的糖尿病治疗方法.干细胞体外培养时可以自发或诱导分化为胰岛素分泌细胞,部分实验证实移植后的胰岛素分泌细胞可以纠正糖尿病小鼠的高血糖状态,这一研究为糖尿病细胞替代治疗带来希望. 相似文献
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糖尿病是严重威胁人类健康的代谢紊乱性疾病.干细胞具有自我更新和多向分化潜能.来源于成体干细胞和胚胎干细胞的胰岛细胞移植也许是有前途的糖尿病治疗方法.干细胞体外培养时可以自发或诱导分化为胰岛素分泌细胞,部分实验证实移植后的胰岛素分泌细胞可以纠正糖尿病小鼠的高血糖状态,这一研究为糖尿病细胞替代治疗带来希望. 相似文献