| Abstract: | Objective To explore the lipid metabolism levels and related factors in children with KD in different stages of disease, so as to provide more scientific and standardized long-term standardized treatment and health management for KD children in Yunnan Province. Methods A total of 400 children who were hospitalized in our hospital from January 2015 to December 2021 and met the diagnostic criteria of Kawasaki disease were collected as the observation group. They were divided into acute phase, subacute phase, recovery phase. There are four sequelae phases, and 100 children with KD are to be included in each phase; 100 healthy children who underwent physical examination in our hospital during the same period were selected as the control group. Two groups of laboratory indicators were detected, including total cholesterol （TC）, triacylglycerol （TG）, low-density lipoprotein cholesterol （LDL-C）, high-density lipoprotein cholesterol （HDL-C）, and apolipoprotein A1 （ApoA1）, apolipoprotein B （ApoB100）, apolipoprotein E （ApoE）, lipoprotein small a （Lpa）, the general demographic data were collected for univariate analysis, and the multiple stepwise regression analysis screened out the influencing factors of LDL-C in children with KD. Results The levels of TC, HDL-C and ApoA1 in the observation group were lower than those in the control group, while the levels of TG, LDL-C, ApoB100, ApoE and Lpa were higher than those in the control group （P > 0.05）.There are abnormal blood lipid metabolism in children with KD during different courses of disease. The levels of TC, HDL-C and ApoA1 in acute phase > subacute phase > recovery phase > sequelae phase, TG, LDL-C, ApoB100, ApoE, Lpa levels in acute phase > sub-acute phase Acute stage > recovery stage > sequelae stage （P > 0.05）, in which serum HDL-C was still low in the recovery stage and the sequel stage. The serum levels of TC, HDL-C, ApoA1, TG, LDL-C, ApoB100, ApoE, and Lpa in children with KD were stable and normal at half a month, 1 month, 3 months, half a year, and 1 year after discharge, and at different time points after discharge Compared with the changes of blood lipid metabolism indexes, there was no significant difference （P > 0.05）. Multiple linear regression analysis showed that male, age > 5 years old, body mass index > 24.0 kg/m2, ethnic minorities, and post-term infants were independent risk factors for HDL-C levels in children with KD （P > 0.05）. Conclusions KD children with different durations of disease have abnormal blood lipid metabolism, which may have a long-term impact. Gender, age, body mass index, ethnicity and expired infants are the influencing factors of HDL-C levels in KD children. It is critical to develop targeted interventions to reduce the long-term impact of dyslipidemia in children with KD. |
