| 款冬花的化学成分 |
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| 引用本文： | 石巍,韩桂秋.款冬花的化学成分[J].中国药学,1996,5(2):63-67. |
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| 作者姓名： | 石巍 韩桂秋 |
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| 作者单位： | [1]北京医科大学天然药物与仿生药物国家重点实验室，北京100083 [2]北京医科大学天然药物与仿生药物国家重点实验室 |
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| 摘 要： | 从款冬花（Tussilago farfara L.0中分离得到四个倍半萜类化合物和两个苯二甲酸酯类化合物，经光谱分析确定其中两个倍半萜类化合物为新结构，命名为款冬花酮（tussilagonone,1)和新款冬花内酯（neotussilagolactone,2）。由血小板活化因子（PAF）引起的血小板聚集实验结果表明，两个新化合物均有较强的抑制PAF活性。
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| 关 键 词： | 款冬花 倍半萜 款冬花酮 新款冬花内酯 PAF抑制剂 |
Chemical Constituents of Tussilago farfara L. |
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| Wei Shi and Gui-Qiu Han National Laboratory of Natural and Biomimetic Drugs,Beijing Medical University,Beijing Received January , Accepted April.Chemical Constituents of Tussilago farfara L.[J].Journal of Chinese Pharmaceutical Sciences,1996,5(2):63-67. |
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| Authors: | Wei Shi and Gui-Qiu Han National Laboratory of Natural and Biomimetic Drugs Beijing Medical University Beijing Received January Accepted April |
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| Affiliation: | Wei Shi and Gui-Qiu Han * National Laboratory of Natural and Biomimetic Drugs,Beijing Medical University,Beijing 100083 Received January 4,1996, Accepted April 23,1996 |
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| Abstract: | Two new sesquiterpenes, named tussilagonone (1) and neotussilagolactone (2), together with two known sesquiterpenes (3) and (4) and two phthalic acid derivatives (5) and (6), were isolated from the flower buds of Tussilago farfara . The structures of (1) and (2) were determined on the basis of spectroscopic analyses. Compounds (1) and (2) exhibited activities against platelet aggregation caused by platelet activating factor. |
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| Keywords: | Tussilago farfara Sesquiterpenes Tussilagonone Neotussilagolactone PAF inhibitors |
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