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| 心适注射液对犬脑组织血流量、脑血管阻力及脑组织抗氧化作用的影响 | |
| 引用本文： | 阚红卫,魏安祥,于东安,黄世福,杨士友,徐鹏夫.心适注射液对犬脑组织血流量、脑血管阻力及脑组织抗氧化作用的影响[J].中国实验方剂学杂志,2009,15(6):56-58. |
| 作者姓名： | 阚红卫 魏安祥 于东安 黄世福 杨士友 徐鹏夫 |
| 作者单位： | 1. 安徽省药物研究所,安徽,合肥,230022;安徽省中药研究与开发重点实验室,安徽,合肥,230022 2. 安徽大学生命科学学院,安徽,合肥,230039 3. 安徽省药品审评认证中心,安徽,合肥,230022 |
| 摘 要： | 目的:研究心适注射液(XSI)对麻醉犬脑组织血流量、脑血管阻力及脑组织超氧化物歧化酶(SOD),丙二醛(MDA)和一氧化氮(NO)含量的影响。方法:将健康犬分为生理盐水(NS)对照组,丹参注射液对照组和心适注射液高、中、低剂量组(4,2,1g·kg-1),3%戊巴比妥钠麻醉后,分离左下肢股静脉,iv心适注射液,分离左颈总动脉测量颈内动脉血流量,分离左下肢股动脉测量平均动脉血压,计算后得出脑组织血流量和脑血管阻力。取脑组织,匀浆,分别测定SOD,MDA和NO含量。结果:心适注射液可显著增加脑组织血流量、降低脑血管阻力、升高脑组织SOD含量、降低MDA和NO含量。结论:心适注射液可改善犬脑部血流、扩张脑血管。 |
| 关 键 词： | 心适注射液 脑组织血流量 脑血管阻力 抗氧化 |
| 收稿时间： | 2008/9/22 0:00:00 |
Effect of Xinshi Injection on Cerebral Blood Flow,Cerebrovascular Resistance and Antioxidant Activity in Brain Tissue in Dogs |
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| KAN Hong-wei,WEI An-xiang,YU Dong-an,HUANG Shi-fu,YANG Shi-you,XU Peng-fu.Effect of Xinshi Injection on Cerebral Blood Flow,Cerebrovascular Resistance and Antioxidant Activity in Brain Tissue in Dogs[J].China Journal of Experimental Traditional Medical Formulae,2009,15(6):56-58. | |
| Authors: | KAN Hong-wei WEI An-xiang YU Dong-an HUANG Shi-fu YANG Shi-you XU Peng-fu |
| Affiliation: | 1. Anhui Institute of Materia Medica, Hefei 230022, China; 2. School of Life Science, Anhui University, Hefei 230039, China;3. Anhui Center for Drug Evaluation & Certification, Hefei 230022, China;4. Anhui Key Laboratory of Chinese Medicine Research and Development,Hefei 230022,China |
| Abstract: | Objective:To study the effect of Xinshi Injection (XSI) on cerebral blood flow (CBF), cerebrovascular resistance (CVR), concentration of SOD, MDA and NO of brain tissue in anesthetized dogs. Methods: Healthy dogs were divided into normal sodium (NS) control group, Danshen injection group and XSI high dose group (4 g·kg-1), middle dose group(2 g·kg-1) and low dose group (1 g·kg-1). After anesthetized by 3% carbrital, the femoral vein of left lower extremity (LLE) was separated to iv XSI; the left common carotid artery was separated to measure the blood flow of internal carotid artery; the femoral artery of LLE was separated to determine mean arterial blood pressure, then the CBF and CVR were calculated. The concentration of SOD, MDA and NO were measured by kits respectively. Results: XSI increased the blood flow in brain tissue and decreased CVR significantly. It also increased concentration of SOD and decreased concentration of MDA and NO in the brain tissue. Conclusion: XSI can improve blood flow of dog's brain and dilate cerebral vessels of dog. |
| Keywords: | Xinshi Injection cerebral blood flow cerebrovascular resistance antioxidant |
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