| 吴婷,刘文,蔡宗尧.精神分裂症患者脑白质的磁共振扩散张量成像研究[J].中国医学影像技术,2006,22(7):978~980 |
| 精神分裂症患者脑白质的磁共振扩散张量成像研究 |
| Study of white matter microstructure in schizophrenia by MR diffusion tensor imaging |
| 投稿时间：2006-02-04 修订日期：2006-04-26 |
| DOI： |
| 中文关键词: 扩散张量成像 磁共振成像 白质 精神分裂症 |
| 英文关键词:Diffusion tensor imaging Magnetic resonance imaging White matter Schizophrenia |
| 基金项目: |
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| 中文摘要: |
| 目的 应用磁共振扩散张量成像技术(DTI)对精神分裂症患者额叶及胼胝体压部脑白质损伤情况与临床症状之间的关系进行初步研究。方法 对22例精神分裂症患者和20例健康志愿者进行脑部DTI扫描后,测量双侧额叶和胼胝体压部的各向异性分数值(FA),应用成组t检验对精神分裂症患者和正常健康对照组的相应区域进行比较,并用部分相关性检验对精神分裂症患者脑中各部位相应FA值与PANSS量表评分之间的关系进行统计。纤维束成像技术(DTT)重建胼胝体和扣带束。结果 精神分裂症患者双侧额叶和胼胝体压部的FA值与正常对照组存在显著性差异(P<0.05),额叶FA值与PANSS量表评分之间存在正相关性(r=0.703,P<0.05),纤维束成像技术不能显示病例组和对照组的差别。结论 精神分裂症患者与正常健康对照组存在脑白质细微结构的差异,DTI技术能够在一定程度上反映精神分裂症患者脑白质受损与临床症状的关系。 |
| 英文摘要: |
| Objective To determine the relationship between the extent of the damage and clinical data in schizophrenia by using diffusion tensor imaging (DTI). Methods Twenty-two patients with schizophrenia and twenty normal controls received diffusion tensor scanning. The fractional anisotropy (FA) values of white matter in schizophrenia patients and normal controls were measured respectively in frontal and the splenium of corpus callosum. Independent-samples t-test for non-paired data was used to test the differences between schizophrenia and controls for FA values. Correlated analysis was applied to reveal the correlations between FA values in frontal and the PANSS scores. Corpus callosum and cingulum were reconstructed by using diffusion tensor tractography (DTT). Results There was significant difference in the FA values in frontal and the splenium of corpus callosum between schizophrenia patients and controls (P<0.05). There was a statistically significant correlation between FA values in frontal and the PANSS scores (r=0.703, P<0.05). DTT can not show different between patients and controls. Conclusion Different white matter microstructure damage was found between schizophrenia patients and controls. Diffusion tensor imaging can reflect the relationship between the degree of white matter abnormalities and the clinical symptom. |
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