ObjectiveTo analyze the characteristics of epidemic situation of HIV/AIDS in Yongzhou from 1993 to 2014, and provide evidence for HIV/AIDS prevention and control strategy.MethodsDescriptive epidemiological analysis was conducted on HIV/AIDS epidemic situation in Yongzhou from 1993 to 2014.ResultsA total of 2 917 HIV /AIDS cases were reported, the reported cases increased year by year; the ratio of male to female cases was 2.30∶1; 52.04% were aged 20-49 years old, 46.76% were aged ≥50 years old, the percentage of population ≥50 years old increased obviously in recent years; the major transmission route was sexual contact (88.48% ), gay transmission accounted for 2.64%.ConclusionThe knowledge about AIDS in Yongzhou should be strengthened, intervention in high risk population should be implemented, scope of detection should be expanded, so as to prevent the transmission of AIDS effectively.