Monospecific but not polyreactive human hybridoma rheumatoid factors exhibit preferential binding specificities for IgG3 and IgG4 |
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| Authors: | M M Newkirk J Rauch |
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| Institution: | (1) Division of Rheumatology, Department of Medicine, McGill University, Montreal General Hospital Research Institute, 1650 Cedar Avenue, H3G 1A4 Montreal, Quebec, Canada |
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| Abstract: | Summary Among 38 human hybridoma-derived monoclonal rheumatoid factors (RFs) generated from patients with either rheumatoid arthritis (RA) or systemic lupus erythematosus (SLE), two groups of RFs can be identified. Monospecific RFs were derived primarily from patients with RA and are characterized by a binding specificity for IgG3 and/or IgG4. Polyreactive RFs were derived largely from patients with SLE and show a broader pattern of reactivity to all four isotypes of IgG. Neither population of RFs was exclusive to either disease. The binding specificities identified appear to be different from the RFs isolated from patients with mixed cryoglobulinemia and may reflect a different antigen selection mechanism. |
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| Keywords: | Rheumatoid factors Rheumatoid arthritis Systemic lupus erythematosus |
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