Histamine H3 receptor agonists |
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Authors: | De Esch I J P Belzar K J |
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Affiliation: | De Novo Pharmaceuticals, Compass House, Vision Park Histon, Cambridge, UK. ideesch@few.vu.nl |
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Abstract: | The SAR of H3 ligands has been difficult to evaluate because of species differences, multiple isoforms and constitutive activity, among other complicating factors. A review is given of the sometimes-conflicting affinity, activity and efficacy data of H3 agonists that has been described in literature to date. |
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