Pathology of space-occupying lesions of the CNS |
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| Affiliation: | 1. Department of Pathology, University of Debrecen, Debrecen, Hungary;2. Department of Pathology, University of Szeged, Szeged, Hungary;3. Department of Oncotherapy, University of Szeged, Szeged, Hungary;4. Department of Obstetrics and Gynecology, University of Debrecen, Debrecen, Hungary;1. Department of Neurosurgery, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52245, USA;2. Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA;3. Carver College of Medicine, University of Iowa, Iowa City, IA, USA;1. Microbiology Department (NSWHP), St George Hospital, Kogarah, Australia;2. School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia |
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| Abstract: | The brain and spinal cord are enclosed by bone, hence expansion of their contents by a space-occupying lesion (SOL) leads to compression and distortion of the tissues of the CNS. Slowly enlarging SOLs can be accommodated by atrophy of adjacent brain or spinal tissue. More rapid enlargement causes a rise in pressure in the affected compartment from the normal level of < 2 kPa (< 15 mmHg), and herniation of the soft CNS tissue into adjacent compartments where the pressure is lower. This has potentially fatal consequences. There are several types of SOL within the CNS (Figure 1) and individual examples are discussed in this contribution. |
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