川芎嗪治疗胎儿宫内生长迟缓中氧自由基与血栓素B2、6-酮-前列腺素1α的相关性研究

探讨胎儿宫内生长迟缓的病理生理改变及有效治疗方法。方法：５８例患者分为川芎嗪组和氨基酸组，分别给予治疗，并测定了８５名正常妊娠及本病患者及有关指标。结果：ＩＵＧＲ者母血脂质过氧化物异常增高，而ＳＯＤ，谷胱甘肽过氧化物酶活力及６－酮－前列腺素１α水平显著下降，血栓素Ｂ２／６－ｋｅｔｏ－ＰＧＦ１α比值增高，该比值与ＳＯＤ，ＧＳＨ－Ｐｘ活力呈负相关，与ＬＰＯ水平呈正相关；

Study on relativity between oxygen free radical and thromboxane B2, 6-keto-PGF1 alpha during ligustrazine treatment of intrauterine growth retardation]

OBJECTIVE: To study the pathophysiological changes and effective treatment of intrauterine growth retardation (IUGR). METHODS: Eighty-five cases with normal pregnancy and 58 IUGR women maternal red blood cell superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), serum lipid peroxide (LPO) and thromboxane B2 (TXB2), 6-keto-PGF1 alpha(6KP) were examined. IUGR group was divided into Ligustrazine group (LIG, 47 cases) and amino acid group (AAG, 11 cases) and treated accordingly. RESULTS: In IUGR group, LPO increased and SOD, GSH-Px activity, 6KP value decreased abnormally, TXB2/6KP ratio significantly increased, which was negative correlated with SOD, GSH-Px activity and positive correlated with LPO level markedly. After treatment, all the changes were improved and almost reached normal range. The fetal outcome showed that the total effective rate was 95.7% in LIG, markedly higher than that in AAG (81.8%, P < 0.05), there was significant difference between LIG and AAG. CONCLUSIONS: The balance of body oxidate/antioxidate system was disturbed and the uteroplacental-fetal circulation was obstracted in IUGR. Ligustrazine could inhibit oxygen free radical, rise SOD, GSH-Px activity, regulate TXA2/PGI2 balance, promote fetal growth.