多中心血管滤泡性淋巴组织增生8例的临床病理特征

目的：探讨多中心血管滤泡性淋巴组织增生（MCD）的临床病理特征。方法：8例血管滤泡性淋巴组织增生（CD）经组织病理证实， 并按Frizzera的标准病理分型为PC型、Mix型和HV型。MCD的诊断除了组织学为CD外，必须有至少一组淋巴结病变，并且淋巴结广泛切除术。结果：淋巴结组织病理PC型6例（75%），Mix型1例，HV型1例。临床有系统性痴症状6例（75%）；肝脾肿大3例（37.5%)；术后6-66月复发5例（62.5%)，其中1例（12.5%)发展为恶性淋巴瘤。结论：MCD倾向于复发进展潜在恶性的临床过程，其发病机制尚待进一步探讨；密切随访观察可早期发现微小病灶和继发的恶性病变；MCD者应选择多种模式的治疗方法。

Multicentric angiofollicular lymph node hyperplasia:clinical and pathological characteristics of eight cases

Purpose:To study the clinical and pathological characteristics of multicentric angiofollicular lymph node hyperplasia (MCD).Methods:Eight patients with histologic diagnosis of angiofollicular lymph node hyperplasia (CD) were identified in the pathologic data base.The lymph node lesions were categorized as PC,Mix and HV types according to the criteria described by Frizzera. Patient with MCD had to have histology of CD within at least one regional group of lymph nodes and all underwent extensive lymphadenectomy.Results:The histologic features of 8 patients were six with PC,one with Mix and one with HV.Five patients presented with systemic symptoms. Three patients had splenomegaly and hapatomegaly. Five patients had local recurrence.Conclusions:MCD tends to recur and has a progressive clinical course with potential for malignancy ,and further study is needed to clarify the pathogenesis. Close follow-up and periodic surveillance are necessary to detect minimal disease and secondary malignant lesions. The patients with MCD should be candidates for multimodality therapy.