| Can intracellular Staphylococcus aureus in osteomyelitis be treated using current antibiotics? A systematic review and narrative synthesis |
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| 作者姓名： | Anja R.Zelmer Renjy Nelson Katharina Richter Gerald J.Atkins |
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| 作者单位： | 1. Centre for Orthopaedic and Trauma Research, Faculty of Health and Medical Sciences, University of Adelaide;3. Royal Adelaide Hospital;4. Richter Lab, Department of Surgery, Basil Hetzel Institute for Translational Health Research, University of Adelaide |
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| 摘 要： | Approximately 40% of treatments of chronic and recurrent osteomyelitis fail in part due to bacterial persistence. Staphylococcus aureus, the predominant pathogen in human osteomyelitis, is known to persist by phenotypic adaptation as small-colony variants(SCVs) and by formation of intracellular reservoirs, including those in major bone cell types, reducing susceptibility to antibiotics.Intracellular infections with S. aureus are difficult to treat; however, there are no evidence-based clinical g...
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