Stable Modifications to the Expression of Neurohormones in the Rat Hypothalamus in a Model of Post-Traumatic Stress Disorder |
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Authors: | V I Mironova E A Rybnikova |
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Institution: | (1) Department of Psychiatry, University of California San Diego, 8939 Villa La Jolla Drive, Suite 200, La Jolla, CA 92037, USA;(2) Department of Psychiatry, VA San Diego Healthcare System, San Diego, CA, USA; |
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Abstract: | We report studies of the neuroendocrine mechanisms of development of an anxiety state in rats using the “stress-restress”
experimental model of post-traumatic stress disorder. Immunocytochemical methods demonstrated significant increases in corticoliberin
expression in both the parvo- and magnocellular parts of the paraventricular nucleus persisting to 10 days after presentation
of the animals with repeated stress. Decreases in vasopressin expression were seen in the paraventricular nucleus of the animals
on the first day after repeated stress. Vasopressin contents in the parvocellular part of the nucleus in animals of the experimental
group were no different at 10 days from those in animals of the control group, while levels in the magnocellular part were
increased. These data provide evidence for the involvement of the hypothalamic component of the vasopressinergic system (along
with the corticoliberinergic system) in the pathogenetic mechanisms of the analog of post-traumatic stress disorder generated
in this model. |
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Keywords: | |
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