| 蛋白质组学在肿瘤防治研究中的应用 |
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| 引用本文： | 杨文理,覃扬. 蛋白质组学在肿瘤防治研究中的应用[J]. 中华肿瘤防治杂志, 2004, 11(6): 659-662 |
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| 作者姓名： | 杨文理 覃扬 |
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| 作者单位： | 1. 泸州医学院生物化学教研室,四川,泸州,646000
2. 四川大学华西医学中心基础与法医学院生化与分子生物学教研室,四川,成都,610041 |
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| 摘 要： | 随着人类基因组测序计划 (humangenomesequenceproject)的完成 ,产生了蛋白质组学 (proteomics) --研究细胞内全部蛋白质的组成及动态变化的一门新兴学科。恶性肿瘤是一种多种基因和蛋白质参与的复杂疾病。综述了在肿瘤防治中蛋白质组学的主要策略和技术 ,及其在肿瘤标志物的筛选和鉴定、肿瘤分类、预后、治疗效果的评价及肿瘤发生机制等方面的研究。
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| 关 键 词： | 蛋白质组学 基因组学 肿瘤 肿瘤预防 肿瘤治疗 |
| 文章编号： | 1009-4571(2004)06-0659-04 |
| 修稿时间： | 2003-11-10 |
Application of proteomics to cancer prevention and therapy research |
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| YANG Wen-Li ,QIN Yang .Luzhou Medical College,Luzhou ,P.R.China. Application of proteomics to cancer prevention and therapy research[J]. Chinese Journal of Cancer Prevention and Treatment, 2004, 11(6): 659-662 |
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| Authors: | YANG Wen-Li QIN Yang .Luzhou Medical College Luzhou P.R.China |
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| Affiliation: | YANG Wen-Li 1,QIN Yang 2 1.Luzhou Medical College,Luzhou 646000,P.R.China 2.Department of Biochemistry and Molecular Biology,West China School of Preclinical and Forensic Medicine,Sichuan University,Chengdu 610041 P.R.China |
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| Abstract: | With the completion of the human genome sequence project, proteomics is an emerging research area about the global protein profiles and their dynamic changes in cell. Cancer is a kind of multi-faceted and complex disease involved in multi-genes and proteins. This review focuses on the main strategies and technology in proteomics and its application to cancer prevention and therapy study, including identification of cancer biomarkers, classification and prognosis of cancer,evaluction of therapeutic efficacy as well as elucidation of cancer mechanisms. |
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| Keywords: | proteomics genomics cancer prevention and therapy |
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