血府逐淤汤联合干扰素对慢性乙型肝炎肝硬化患者肝纤维化及 门静脉血流动力学的影响

目的观察血府逐淤汤联合干扰素对慢性乙型肝炎肝硬化患者肝纤维化及门静脉血流动力学的影响。方法 64例慢性乙型肝炎肝硬化患者分为2组,每组32例。观察组患者给予血府逐淤汤联合干扰素治疗;对照组患者给予干扰素治疗,疗程均为3个月,检测2组患者治疗前后血清肝纤维化指标和门静脉血流动力学指标。结果观察组总有效率显著高于对照组(P<0.05)。治疗前2组患者肝纤维化指标比较差异无统计学意义(P>0.05)。与治疗前比较,观察组治疗后血清Ⅲ型前胶原(PCⅢ)、透明质酸(HA)和层黏蛋白(LN)水平显著降低(P<0.05),对照组血清HA水平显著降低(P<0.05),但血清PCⅢ和LN水平无显著下降(P>0.05);治疗后观察组血清PCⅢ、HA和LN水平显著低于对照组(P<0.05)。治疗前2组门静脉主干内径、平均血流速度及血流量比较差异均无统计学意义(P>0.05)。与治疗前比较,观察组治疗后门静脉平均血流速度升高(P<0.05),门静脉血流量减少(P<0.05),但门静脉主干内径无显著变化(P>0.05);对照组治疗后门静脉主干内径、血流速度和血流量与治疗前比较差异均无统计学意义(P>0.05)。治疗后观察组门静脉平均血流速度高于对照组(P<0.05),门静脉血流量小于对照组(P<0.05);但2组门静脉主干内径比较差异无统计学意义(P>0.05)。结论血府逐淤汤联合干扰素治疗可改善慢性乙型肝炎患者肝纤维化及血流动力学。

Influence of Xuefu Zhuyu Tang combined with interferon on hepatic fibrosis and portal venous haemodynamics in patients with chronic hepatitis B and hepatic fibrosis

Objective To observe the influence of Xuefu Zhuyu Tang combined with interferon on hepatic fibrosis and portal venous haemodynamics in patients with chronic hepatitis B and hepatic fibrosis.Methods Sixty-four patients with chronic hepatitis B and hepatic fibrosis were divided into two groups,thirty-two cases in each group.The patients of observation group were treated with Xuefu Zhuyu Tang and interferon,while the patients of control group were treated with interferon for three months.The indexes of hepatic fibrosis and portal venous haemodynamics were detected before and after treatment.Results The total effective rate of observation group was significantly higher than that of control group(P<0.05).There was no statistical significance in the indexes of hepatic fibrosis between two groups before treatment(P>0.05).After treatment,the levels of procollagen type Ⅲ(PCⅢ),hexadecenoic acid(HA) and laminin(LN) degraded significantly in observation group(P<0.05),while the level of serum HA degraded significantly in control group(P<0.05),but the levels of PCⅢ and LN didn′t degraded significantly(P>0.05).After treatment,the levels of serum PCⅢ,HA and LN in observation group were significantly lower than those in control group(P<0.05).There were no significant difference in the inner diameter,average blood flow rate and blood flow of portal vein between two groups before treatment(P>0.05).After treatment,in observation group,the average blood flow rate of portal vein increased(P<0.05),the blood flow decreased(P<0.05),but there was no significant change in the inner diameter of main portal vein(P>0.05).There was no significant difference in the inner diameter,average blood flow rate and blood flow of portal vein in control group before and after treatment(P>0.05).After treatment,the average blood flow rate of portal vein in observation group was higher than that in control group(P<0.05),the blood flow of portal vein in observation group was less than that in control group(P<0.05),but there was no significant difference in the inner diameter of main portal vein between two groups(P>0.05).Conclusion Xuefu Zhuyu Tang combined with interferon treatment can improve hepatic fibrosis and haemodynamics in patients with chronic hepatitis B.