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Multilayer nanoparticles for sustained delivery of exenatide to treat type 2 diabetes mellitus |
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| Authors: | Jae Yeon Kim Hwanbum Lee Keun Sang Oh Seho Kweon Ok-cheol Jeon Youngro Byun Kwangmeyung Kim Ick Chan Kwon Sang Yoon Kim Soon Hong Yuk |
| Institution: | 1. College of Pharmacy, Korea University, 2511 Sejongro, Sejong 339-700, Republic of Korea;2. Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 151-742, Republic of Korea;3. Biomedical Research Center, Korea Institute of Science and Technology, 39-1 Hawolgok-dong, Seongbuk-gu, Seoul 136-791, Republic of Korea;4. Department of Otolaryngology, Asan Medical Center, University of Ulsan, College of Medicine, 388-1 Pungnap-dong, Songpa-gu, Seoul 138-736, Republic of Korea |
| Abstract: | A method for the sustained delivery of exenatide was proposed using nanoparticles (NPs) with a core/shell structure. The interactions between lipid bilayers and Pluronics were utilized to form various NPs using a layer-by-layer approach. Transmittance electron microscopy and dynamic light scattering were used to examine the morphology of the NPs. The in vitro release pattern was observed as a function of changes in the structure of the NPs, and the structural integrity of exenatide released was examined by SDS–PAGE analysis. Pharmacokinetics and antidiabetic effects were also observed with the structural change of NPs using in vivo animal models. In vitro–in vivo correlation was discussed in relation to manipulation of the NP structures. |
| Keywords: | Core/shell nanoparticles Layer-by-layer approach Pluronics Lipid bilayers Sustained delivery of exenatide |
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