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目的 研究乳腺癌腋窝淋巴结发生癌转移和未发生癌转移时的免疫功能。方法2004年8月至2005年7月采用流式细胞技术检测乳腺癌病人乳腺癌前哨淋巴结（SLN）与乳腺癌非前哨淋巴结（NSLN）中免疫细胞CD3^＋T、CD4^＋T、CD8^＋T、CD16^＋NK、CD^19^＋B的比例，并相互比较。结果淋巴结未发生癌转移时，SLN与NSLN的免疫细胞CD3^＋T、CD4^＋T、CD8^＋T、CD16^＋NK、CD^19^＋B的比例差异无统计学意义（P〉0．05）；而且当SLN与NSLN发生癌转移后，它们的免疫细胞的比例也无差异。但SLN发生癌转移与未发生癌转移时相比，其CD4^＋T、CD8^＋T、CD16^＋NK的比例发生显著改变（P〈0．05），CD3^＋T、CD19^＋B的比例改变无统计学意义（P〉0．05）。结论 当腋窝淋巴结未发生癌转移时，它仍有正常的免疫功能。当腋窝淋巴结发生癌转移后，它的免疫微环境发生了改变，免疫功能呈现一种抑制状态。

Distribution On immune function of the axilla lymph nodes in breast cancer.

??Objective:To investigate the immune function of Axilla lymph nodes which cancer cells metastasis and not metastasis in breast cancer. Methods:It used flow cytometry to calculate the percent of lymphocyte subsets of the axilla lymph nodes and compare the result with each other between August 2004 and July 2005. Results:Whether cancer cells metastasis to the axilla lymph nodes or not,the percentage of lymphocytes CD3+T??CD4+T??CD8+T??CD16+NK??CD19+B had no statistical difference (P>0.05).When cancer cells metastasis to SLN,the percentage of lymphocytes CD4+T??CD8+T??CD16+NK had statistical difference (P<0.05),and the percentage of CD3+T??CD19+B had no statistical difference (P>0.05). Conclusion:When the axilla lymph nodes has no cancer cells metastasis,it’s immune function is natural.Once lymph nodes has cancer cells metastasis,it’s immune entironment is transformation,and so the immune function is bated.