胰岛素与口服降糖药对新诊断2型糖尿病患者β细胞功能的影响

目的比较胰岛素（Ins）与口服降糖药（OHA）治疗对新诊断2型糖尿病（T2DM）患者胰岛β细胞功能的影响。方法64例新诊断T2DM患者随机分为Ins组和OHA治疗组。定期检测PG、Ins、C-P水平及其他相关指标，用HOMA-β、HOMA-IR及△I30／△G30来评价胰岛功能变化。结果（1）随访至6个月时，两组上述指标均元统计学差异（P均〉0．05）。（2）随访至12个月时，与OHA组比，Ins组HOMA-β及△I30／△G30较治疗前显著上升（P〈0．05）。两组HOMA-IR无统计学差异（P〉0．05）。结论与0HA相比，早期Ins治疗能更好地保护B细胞功能。

Comparison of pancreatic islet functions between insulin and oral-hypoglycaemic-agents therapy in newly diagnosed type 2 diabetes mellitus

Objective To investigate the effect of insulin （INS）and oral hypoglycaemic agents （OHA） on the function of islet β cells in newly diagnosed type 2 diabetes mellitus（T2DM）. Methods Sixty four newly diagnosed T2DM patients were randomly assigned to insulin group（Ins group,n=30） and OHA group （n= 34）. Blood was collected at regular intervals to determine plasma levels of glucose,insulin and C peptide and others. HOMA-β cells index. （HBCI）, insulin resistence index （HOMA-IR）, △I30/△G30 were calculated to assesse the islet β cell function. Results At the time of sixth month follow up, no significant differences in islet function were found between the two groups（P〉0.05）. At the end of follow up （at twelfth month） ,the HBCI and △I30/△G30 increased significantly in Ins versus OHA group（P〈0. 05）. The sex, age, BMI, systolic and diastolic blood pressure and HbA1 c showed no difference between two groups （P〉 0.05）. Conclusions Compared with OHA, INS can protect islet β cell function of diabetes mellitus.