GBS急性期湿热证与垂体-肾上腺皮质轴的关系研究

目的:探讨吉兰-巴雷综合征(GBS)急性期湿热证与垂体-肾上腺皮质轴的关系。方法:对GBS患者进行中医辨证,分为湿热证组和非湿热证组。对两组分别进行皮质醇(COR)和促肾上腺皮质激素(ACTH)含量的测定,并与正常对照组进行比较。结果:GBS急性期湿热证组COR含量高于非湿热证组和正常对照组(P<0.05),湿热证组ACTH含量低于正常对照组(P<0.05),与非湿热证组比较无统计学差异。结论:GBS急性期湿热证患者的垂体-肾上腺皮质轴功能表现为ACTH下降COR升高的非ACTH依赖性肾上腺皮质激素分泌。

Relation of Syndrome of Damp-heat of Acute Period of GBS with Hypophysis-Adrenal Cortex Axis

Objective: To discuss the relation of syndrome of damp-heat of acute period of GBS with hypophysis-adrenal cortex axis.Mesthod: 34 patients with GBS were separate two groups(group of damp-heat syndrome,group of nondamp-heat syndrome) by differentiated syndromes of TCM.This two groups and normal control group were detected the level of cortisol(COR) and adrenocorticotropin(ACTH).These data were compared with normal control group.Result: The level of COR of damp-heat syndrome group was higher than nondamp-heat syndrome group and normal control group(P<0.05).The level of ACTH of damp-heat syndrome group was lower than normal control group(P<0.05).But comparing with nondamp-heat syndrome group,there was not obvious difference.Conclusion: Hypophysis-adrenal cortex axial function of patients with damp-heat syndrome of acute period of GBS shows non-ACTH-mediated regulation of adrenal cortex which manifests the level of ACTH decrease and the level of COR increase.