44例新生儿败血症病原菌及耐药性分析

目的 探讨新生儿败血症病原学特点及致病菌耐药情况.方法 分析我院NICU 44例血培养阳性新生儿败血症培养检出菌及药敏结果.结果 检出病原菌44株,其中革兰阳性菌为34株（77.27%）,革兰阴性菌为8株（18.18%）;真菌2株（4.55%）.革兰阳性菌以凝固酶阴性葡萄球菌（CONS）为主,革兰阴性菌以大肠埃希菌为常见;CONS对青霉素G、红霉素、头孢唑啉的耐药率高,对万古霉素未发现产生耐药.结论 我院NICU新生儿败血症病原菌以CONS 为主,重视病原菌耐药性检测,根据药敏选用抗菌药物,可减少细菌耐药性的产生.

Analysis of bacterial distribution and drug resistance in 44 infants with neonatal sepsis

Objective To investigate the etiology of sepsis and to analyze their drug resistance in neonates. Methods The pathogenic bacteria and the results of drug sensitivity test of 44 cases of neonate sepsis in NICU were analyzed. Results 44 strains of patho- genic bacteria were detected, which included 34 strains of gram positive bacteria （77.27%）, 8 strains of gram negative bacteria （ 18.18% ）, and 2 strains of fungi （4.55%）. Coagulase negative staphylococcus （CONS） was the main bacteria in gram-positive bacteri- a, and escherichia coli was the main bacteria in gram-negative bacteria. CONS showed a certain resistance to erythromycin, penicillin G, and cefazolin, but had no resistance to vancomycin. Conclusion The main pathogen of neonatal septicemia in NICU is CONS, which should be paid attention to the detection of drug resistance of pathogenic bacteria and reasonable use of antibiotics according to the results of drug sensitivity test in order to reduce the drug resistance of bacteria.