| Role of Interferon-γ in GVHD and GVL |
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| 引用本文： | Yang YG,Wang H,Asavaroengchai W,Dey BR. Role of Interferon-γ in GVHD and GVL[J]. Cellular & molecular immunology, 2005, 2(5): 323-329 |
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| 作者姓名： | Yang YG Wang H Asavaroengchai W Dey BR |
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| 作者单位： | [1]Transplantation Biology Research Center, Surgical Service, Massachusetts General Hospital, Harvard Medical School, MGH-East, Building 149, 13th Street, Boston, MA 02129, USA [2]Bone Marrow Transplant Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA [3]Corresponding to： Dr. Yong-Guang Yang, Transplantation Biology Research Center, Massachusetts General Hospital, MGH East, Bldg 149-5102, 13th Street, Boston, MA 02129, USA |
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| 摘 要： | Interferon （IFN）-γ, a potent proinflammatory cytokine produced by multiple types of cells （e.g., activated T, NK and NKT cells）, plays important and complex roles in both innate and adaptive immune responses. There may be a correlation between the IFN-γ level and GVHD severity in patients receiving allogeneic hematopoietic cell transplantation. However, such a correlation may just reflect the presence of large numbers of activated T cells, and does not necessarily imply a harmful role of IFN-γ in the pathogenesis of GVHD. There has been increasing experimental evidence that IFN-γ is not required and may even inhibit GVHD. Paradoxically, IFN-γ facilitates graft-versus-leukemic （GVL） effects. Thus, IFN-γ blockade is likely deleterious in patients after allogeneic hematopoietic cell transplantation, and not beneficial as previously suggested.
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| 关 键 词： | 干扰素-γ 白血病 病理机制 临床表现 |
| 收稿时间： | 2005-10-01 |
| 修稿时间： | 2005-10-21 |
Role of Interferon-gamma in GVHD and GVL |
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| Yang Yong-Guang,Wang Hui,Asavaroengchai Wannee,Dey Bimalangshu R. Role of Interferon-gamma in GVHD and GVL[J]. Cellular & molecular immunology, 2005, 2(5): 323-329 |
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| Authors: | Yang Yong-Guang Wang Hui Asavaroengchai Wannee Dey Bimalangshu R |
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| Affiliation: | Transplantation Biology Research Center, Surgical Service, Massachusetts General Hospital, Harvard Medical School, MGH-East, Building 149, 13th Street, Boston, 02129, USA. yongguang.yang@tbrc.mgh.harvard.edu |
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| Abstract: | Interferon (IFN)-gamma, a potent proinflammatory cytokine produced by multiple types of cells (e.g., activated T, NK and NKT cells), plays important and complex roles in both innate and adaptive immune responses. There may be a correlation between the IFNgamma level and GVHD severity in patients receiving allogeneic hematopoietic cell transplantation. However, such a correlation may just reflect the presence of large numbers of activated T cells, and does not necessarily imply a harmful role of IFN-gamma in the pathogenesis of GVHD. There has been increasing experimental evidence that IFN-gamma is not required and may even inhibit GVHD. Paradoxically, IFN-gamma facilitates graft-versus-leukemic (GVL) effects. Thus, IFN-gamma blockade is likely deleterious in patients after allogeneic hematopoietic cell transplantation, and not beneficial as previously suggested. |
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