| 原子力显微镜在细胞生物学研究中的应用 |
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| 引用本文： | 谭毅,王贵学,蔡绍皙. 原子力显微镜在细胞生物学研究中的应用[J]. 生物医学工程学杂志, 2004, 21(1): 160-163 |
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| 作者姓名： | 谭毅 王贵学 蔡绍皙 |
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| 作者单位： | 重庆大学,生物工程学院,国家教育部生物力学与组织工程重点实验室,重庆,400044 |
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| 基金项目： | 国家人事部留学回国人员资助项目 (人发 [2 0 0 1] 119号 ) |
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| 摘 要： | 下丘脑分泌的促甲状腺激素释放激素 (Thyrotropin- releasing hormone,TRH)促进垂体促甲状腺激素(Thyrotropin,TSH)的合成和释放 ,而多巴胺 (Dopam ine,DA)和生长抑素 (Som atostatin,SST)抑制 TSH的合成和释放 ,甲状腺激素也对 TSH产生反馈抑制作用。甲状腺功能减退患者 ,伴随多巴胺能神经元功能 (Dopam inergictone)的降低和 TSH基础水平升高。胃复安 (Metoclopramide,MCP)是多巴胺第二受体拮抗剂 ,能加速提高甲低患者血 TSH水平 ,特别是当运用于分化型甲癌 (Differentiated thyroid carcinom a,DTC)病人时 ,能缩短停用左旋甲状腺素 (L- thyroxine,L- T4 )的时间和减轻甲状腺机能减退所致的症状和体征 ,有助于对 DTC病灶的 1 31 I显像诊断和 1 31 I治疗
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| 关 键 词： | 胃复安 多巴胺 促甲状腺激素 分化型甲癌 |
Application of Atomic Force Microscopy in Cell Biology |
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| Yi Tan,Guixue Wang,Shaoxi Cai. Application of Atomic Force Microscopy in Cell Biology[J]. Journal of biomedical engineering, 2004, 21(1): 160-163 |
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| Authors: | Yi Tan Guixue Wang Shaoxi Cai |
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| Affiliation: | Key Laboratory for Biomechanics & Tissue Engineering, State Ministry of Education, College of Bioengineering Chongqing University, Chongqing 400044, China. |
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| Abstract: | The atomic force microscopy(AFM), an important instrument for the study of cell biology, has been used to image the living cells and localize the cell surface receptors under physiological conditions by perfect high resolution. It was also utilized in the investigations of the cytoskeleton, biological process and interactions between cells. The applications of AFM in cell biology have been achieved greatly in recent years and many results present a good promise in biomedical and clinical medical fields. |
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| Keywords: | Atomic force microscopy(AFM) Cell biology Properties of cell surface Cytoskeleton |
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