合成脂蛋白作为纳米药物载体的研究进展

合成脂蛋白是生物药物、化学药物和造影剂等的有效靶向递送载体，它们具有极小的粒径、良好的生物相容性、合适的半衰期和脂蛋白受体的特异性结合能力，与传统的天然脂蛋白相比，既保留了其原有的生物学特征和功能，又在药物递送方面展现出优良特性。本文介绍了合成脂蛋白作为纳米药物载体的研究进展，综述了合成脂蛋白的制备方法、体内外应用以及脂蛋白作为纳米药物载体应用受限的解决方法，对合成脂蛋白的研究前景进行了展望。

Advances of synthetic lipoproteins as drug nanovectors

Synthetic lipoproteins are efficient nanovectors for targeting delivery of biological drugs, chemical drugs and imaging contrast agents and so on. They have ultra-small particle size, excellent biocompatibility, favorable circulation half-life and specific lipoprotein-receptors-binding capacity of lipoprotein receptors. Compared with traditional natural lipoproteins, synthetic lipoproteins possess both native biochemical properties and functions, and superior drug delivery potentials. This paper introduces the development of lipoproteins as drug nanovectors and reviews preparation methods of synthetic lipoproteins, in vitro and in vivo applications and the approaches employed to expand the limited applications of lipoproteins as drug nanovectors. Further development of synthetic lipoproteins is also proposed.