| 载药金纳米粒的研究进展 |
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| 引用本文： | 张鑫,刘颖,冯年平.载药金纳米粒的研究进展[J].药学实践杂志,2016,34(3):196-200,236. |
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| 作者姓名： | 张鑫 刘颖 冯年平 |
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| 作者单位： | 上海中医药大学中药学院, 上海 201203,上海中医药大学中药学院, 上海 201203,上海中医药大学中药学院, 上海 201203 |
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| 基金项目： | 国家自然科学基金项目(81202925) |
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| 摘 要： | 近年来,作为一种新型药物递送系统,金纳米粒已引起了广泛关注。由于其特殊的物理化学性质,能与多种类型药物发生相互作用,如蛋白质、核酸、小分子药物等,从而可应用于肿瘤治疗和检测。笔者对载药金纳米粒的制备方法、载药方式和安全性等问题进行综述。
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| 关 键 词： | 金纳米粒 制备方法 载药方式 安全性 轭合物 |
| 收稿时间： | 2015/10/29 0:00:00 |
| 修稿时间： | 2016/1/29 0:00:00 |
Research progress of drug-loading gold nanoparticles |
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| ZHANG Xin,LIU Ying and FENG Nianping.Research progress of drug-loading gold nanoparticles[J].The Journal of Pharmaceutical Practice,2016,34(3):196-200,236. |
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| Authors: | ZHANG Xin LIU Ying and FENG Nianping |
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| Institution: | School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China,School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China and School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China |
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| Abstract: | In recent years, as a novel drug delivery system, gold nanoparticles have attracted widespread attention. Because of their special physicochemical properties, such as quantum size effect, unique optical phenomenon, easily reacting with thiol compounds or disulfides and so on, gold nanoparticles can delivery variety of types of drugs, like proteins, nucleic acid, small molecular drugs, therefore they can be applied in tumor treatment and detection. In this paper the preparation of drug-loading gold nanoparticles, their drug-loading ways and safety issues were reviewed. |
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| Keywords: | gold nanoparticles preparation methods drug-loading ways safety conjugate |
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