| 积雪草酸对颅脑损伤的保护作用及其机制研究 |
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| 引用本文： | 顾申勇,朱秋珍,王静,刘玉兰,张悦,芮耀诚,章越凡,李铁军. 积雪草酸对颅脑损伤的保护作用及其机制研究[J]. 药学实践杂志, 2016, 34(3): 206-209,288 |
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| 作者姓名： | 顾申勇 朱秋珍 王静 刘玉兰 张悦 芮耀诚 章越凡 李铁军 |
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| 作者单位： | 第二军医大学药学院药理学教研室, 上海 200433;复旦大学附属中山医院青浦分院药剂科, 上海 201700,第二军医大学药学院药理学教研室, 上海 200433,安徽中医药大学药学院, 安徽 合肥 230031,第二军医大学药学院药理学教研室, 上海 200433,安徽中医药大学药学院, 安徽 合肥 230031,第二军医大学药学院药理学教研室, 上海 200433,第二军医大学药学院药理学教研室, 上海 200433,第二军医大学药学院药理学教研室, 上海 200433 |
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| 基金项目： | 上海市青浦区卫生和计划生育委员会科研课题(W2015-02) |
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| 摘 要： | 目的 研究积雪草酸对颅脑损伤的保护作用及其机制。方法 采用落重法建立大鼠闭合性颅脑损伤模型和液压冲击颅脑损伤模型,测定大鼠脑组织含水量、血脑屏障通透性、以及观察脑组织病理形态学变化,研究积雪草酸对颅脑损伤的保护作用;用酶联免疫吸附测定(ELISA)和聚合酶链式反应(PCR)检测炎症因子肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)的表达,探讨其作用机制。结果 积雪草酸可显著减少颅脑损伤后脑组织含水量,减轻血脑屏障通透性,改善脑组织细胞形态;并且可以显著抑制颅脑损伤后炎症因子TNF-α、IL-1β、IL-6的表达。结论 积雪草酸具有保护颅脑创伤的作用,其作用机制可能与其抑制炎症作用有关。
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| 关 键 词： | 积雪草酸 颅脑损伤 炎症 |
| 收稿时间： | 2016-03-18 |
| 修稿时间： | 2016-04-01 |
Protective effects and mechanism of Asiatic Acid on traumatic brain injury |
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| GU Shenyong,ZHU Qiuzhen,WANG Jing,LIU Yulan,ZHANG Yue,RUI Yaocheng,ZHANG Yuefan and LI Tiejun. Protective effects and mechanism of Asiatic Acid on traumatic brain injury[J]. The Journal of Pharmaceutical Practice, 2016, 34(3): 206-209,288 |
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| Authors: | GU Shenyong ZHU Qiuzhen WANG Jing LIU Yulan ZHANG Yue RUI Yaocheng ZHANG Yuefan LI Tiejun |
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| Affiliation: | Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, China;Department of Pharmacy, Zhongshan Hospital Qingpu Branch Affiliated to Fudan University, Shanghai 201700, China,Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, China,School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230031, China,Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, China,School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230031, China,Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, China,Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, China and Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, China |
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| Abstract: | |
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| Keywords: | Asiatic Acid traumatic brain injury inflammatory cytokines |
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