氯诺昔康与布托啡诺用于腹腔镜胆囊切除术后镇痛效果

目的：对比观察氯诺昔康和布托啡诺用于腹腔镜胆囊切除术（LC）后镇痛的临床效果。方法：90例ASAⅠ-Ⅱ级择期在全麻下行腹腔镜胆囊切除术的患者，随机分为氯诺昔康、布托啡诺和生理盐水3组，每组30例。各组患者于术毕伤口疼痛时，分别静注氯诺昔康8mg、布托啡诺1mg和生理盐水2mL，观察并记录各组注药后1、6、12、24h的疼痛视觉模拟评分（VAS值）、镇静评分、舒适评分、生命体征的变化和不良反应的发生情况。结果：氯诺昔康、布托啡诺组术后各时点VAS评分、镇静评分、舒适评分与生理盐水组比较差异有统计学意义（P〈0．01），术后镇痛期间生命体征变化组间比较差异无统计学意义（P〉0．05），氯诺昔康组术后恶心、呕吐发生率低于生理盐水组（P〈0．05），注药后1h布托啡诺组头晕和嗜睡的发生率明显高于氯诺昔康组（P〈0．05）。结论：氯诺昔康和布托啡诺对LC患者均具有良好的术后镇痛效果，术后不良反应发生率低。

Effects of postoperative analgesia with lornoxicam and butorphano in patients undergoing laparoscopic cholecystectomy

AIM： To investigate the effect of postoperative analgesia with Lomoxicam and butorphano after laparoscopic cholecystectomy （LC）. METHODS： 90 ASA Ⅰ - Ⅱ patients scheduled for LC were randomly divided into three groups： group lomoxicam （n = 30） received lomoxicam 8 mg, group butorphano （ n = 30） received butorphano 1 mg, group NS （ n = 30） received 0.9 % NS 2 mL at the time of the complaint of pain by the patients after extubate of tracheal catheter . Postoperative abdomen pain was assessed by visual analog scale （VAS）, the patients were assessed by bnmgmann comfort scale （BCS） and Ramesay score （RS） within 1,6, 12, 24 hours postoperatively. Side-effects were also assessed. RESULTS： The patients of group lomoxicam and butorphano had significantly higher BCS and RS scores than group NS （ P 〈 0.01 ）, both of them also had significantly lower VAS than group NS （P 〈 0.01 ）. Group lomoxicam caused no more sideeffect, such as nausea, vomiting than group butorphano and NS（ P 〈 0.05）. CONCLUSION： The study suggests that postoperative analgesia with lomoxicam 8 mg or butorphano 1 mg provide satisfactory postoperative pain relief with no more side-effects for patients undergoing LC.