Role of mast cells in reparative processes in inflammation |
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Authors: | N A Klimenko S V Tatarko |
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Institution: | (1) Department of Pathological Physiology, Kharkhov Medical Institute, Kharkov, USSR |
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Abstract: | Using the model of acute infectious peritonitis in rats, it is shown that inflammation induced in the absence of mast cells
is characterized by marked inhibition of reparative processes. The most significant accumulation of functionally active fibroblasts
and the development of granulations and young connective tissue in the mesentery occur 5–10 days after flogogen injection
in the natural development of inflammation and after 10–20 days in the absence of mast cells. The data suggest that under
natural conditions mast cells directly or indirectly stimulate reparative processes.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N
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3, pp. 262–265, March, 1995
Presented by E. D. Gol'dberg, Member of the Russian Academy of Medical Sciences |
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Keywords: | inflammation mast cells repair |
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