| 极小胚胎样干细胞的生物学特性 |
| |
| 引用本文： | 陈欣,黄淑帧. 极小胚胎样干细胞的生物学特性[J]. 医学分子生物学杂志, 2010, 7(2). DOI: 10.3870/j.issn.1672-8009.2010.02.013 |
| |
| 作者姓名： | 陈欣 黄淑帧 |
| |
| 作者单位： | 上海市儿童医院,上海交通大学医学遗传研究所,上海市,200040 |
| |
| 摘 要： | 近年来,研究者从小鼠骨髓和其他组织脏器中分离并纯化了一类数量极其稀少的极小胚胎样干细胞(very small embryonic-like stem cells,VSELs).VSELs不仅表达多能干细胞的表面分子标记,并能向3个胚层方向分化.有学者推测,VSELs可能是在哺乳动物组织/器官的发育早期迁移并定居下来的,且能在特定情况下向组织特异的单潜能干细胞方向分化.据此,VSELs可能在成体组织的更新和损伤组织的再生修复过程中发挥重要作用.
|
| 关 键 词： | 极小胚胎样干细胞 潜能干细胞 原始生殖干细胞 |
Very Small Embryonic-Like(VSEL)Stem Cells |
| |
| CHEN Xin,HUANG Shuzhen. Very Small Embryonic-Like(VSEL)Stem Cells[J]. Journal of Medical Molecular Biology, 2010, 7(2). DOI: 10.3870/j.issn.1672-8009.2010.02.013 |
| |
| Authors: | CHEN Xin HUANG Shuzhen |
| |
| Abstract: | Recently,the investigators identified a rare population of very small embryonic-like stem cells(VSELs)from the murine bone marrow and other adult tissues.VSELs not only express several important characteristic biological marker,they may also differentiate among all three germ layers.Some scholars hypothesized that VSELs are deposited during gastrulation and organogenesis in developing organs/tissues of mammals as a population of pluripotent stem cells that give rise to tissue committed monopotent stem cells.Therefore VSELs could play a pivotal role in normal rejuvenation of adult tissues as well as involvement in regeneration of damaged organs.This data will be presented in this review. |
| |
| Keywords: | very small embryonic-like stem cells pluripotent stem cells primordial germ cells |
| 本文献已被 万方数据 等数据库收录！ |
|
