An inhibitor of murine stem cell proliferation produced by normal human bone marrow |
| |
Authors: | Eric G. Wright Patricia Sheridan Malcolm A.S. Moore |
| |
Affiliation: | Laboratories of Developmental Hematopoiesis, Sloan Kettering Institute for Cancer Research, New York, U.S.A. |
| |
Abstract: | Media conditioned by normal human bone marrow cells contain a specific inhibitor of haemopoietic stem cell proliferation. Molecular ultrafiltration and dose response studies indicate that it is similar to a previously described factor obtained from freshly isolated or long-term cultured murine bone marrow cells. It is suggested that the mechanisms involved in the control of murine and human stem cell proliferation may be essentially identical. |
| |
Keywords: | Stem cell proliferation regulation endogenous factor Spleen colony-forming units (haemopoietic stem cells) Colony-forming units in culture (granulocyte-macrophage committed precursors) Phenylhydrazine-used as prefix denotes treatment of donor mice Human bone marrow conditioned medium Cultured human bone marrow conditioned medium I nominal molecular weight fractions of conditioned media 500-10,000 Daltons II nominal molecular weight fractions of conditioned media 10,000–30,000 Daltons III nominal molecular weight fractions of conditioned media 30,000–50,000 Daltons IV nominal molecular weight fractions of conditioned media 50,000–100,000 Daltons Tritiated thymidine |
本文献已被 ScienceDirect 等数据库收录! |