肾血管性高血压大鼠模型中ET1和CGRP的变化

目的探讨降钙素基因相关肽(CGRP)及血浆内皮素(ET1)在高血压病中的作用。方法选用正常血压大鼠42只,随机分对照组、手术组、假手术组,分别观察血压值、CGRP及ET1值。结果手术组与正常组比较血压明显高于正常对照组(P<0.01),假手术组与正常对照组比较,血压无明显变化(P>0.05);手术组与对照组比较CGRP显著升高(P<0.01);假手术组与正常对照组比较,CGRP未见升高(P>0.05)。手术组与对照组比较ET1无明显变化(P>0.05)。结论CGRP在肾血管性高血压的发生发展中具有保护作用。ET1与CGRP是心血管系统中的一对拮抗因子,与CGRP的作用相反,ET1有较强的缩血管作用,从而导致血压升高。

Effect of Calcitonin Gene-Related Peptide and ET1 on Rat Model of Renovascular Hypertension

Objective To explore the effect of calcitonin gene-related peptide(CGRP) and ET_1 on hypertension.Methods 42 rats with normal blood pressure were randomly divided into operation,sham operation and control groups.The level of CGRP and ET_1 were determined at 2,4,6,8 and 10 weeks after treatment,respectively.Results The blood pressure in rats of the operation group was significantly higher than that in the control group(P<0.01),but there was not significant difference between that of rats in the sham operation and normal control groups.CGRP of the operation group was significantly higher than that of control group(P<0.05).ET_1 of the operation group was significantly higher than that of control group.No significant difference was found between the ET_1 and CGRP in the sham operation group and control group.Conclusion CGRP has a protective effect on blood vessels in renal arterial hypertension,but ET_1 exerts a vasoconstrictive action.