| 细胞周期素A与肿瘤的发生及预后 |
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| 引用本文： | 李志远. 细胞周期素A与肿瘤的发生及预后[J]. 医学综述, 2010, 16(8) |
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| 作者姓名： | 李志远 |
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| 作者单位： | 南华大学附属南华医院,湖南,衡阳,421001 |
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| 摘 要： | 细胞周期素A基因定位在染色体4q27上,为S期的特征性细胞周期蛋白,并且是一种具有癌基因性质的细胞周期蛋白,是G1期向S期转移的限速因素。细胞周期素A含有一个周期素盒,还含有一个降解盒。参与调节细胞DNA合成和有丝分裂的作用,在人类多种肿瘤中都过度表达,其过度表达与肝脏、颅脑、血液系统、子宫、软组织等肿瘤预后呈负相关。
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| 关 键 词： | 细胞周期素A 肿瘤 周期素盒 降解盒 |
CyclinA in the Carcinogenesis and Prognosis of Tumor |
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| LI Zhi-yuan. CyclinA in the Carcinogenesis and Prognosis of Tumor[J]. Medical Recapitulate, 2010, 16(8) |
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| Authors: | LI Zhi-yuan |
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| Abstract: | CyclinA is located at 4q27 in chromosome as a special cell cycle protein in S phase,which control G1 phase to transfer S phase and has oncogene character.CyclinA contain a cyclin box,and a destruction box.CyclinA adjust cell DNA composition and mitosis,excessive expression in many kinds of tumor,and associated with bad prognosis with liver cancer,intracranial tumors,blood tumors,womb tumors,and some soft tissue tumors. |
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| Keywords: | CyclinA Tumor Cyclin box Destruction box |
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