In vitro activities of penciclovir and acyclovir against herpes simplex virus types 1 and 2. |
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| Authors: | A Weinberg B J Bate H B Masters S A Schneider J C Clark C G Wren J A Allaman M J Levin |
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| Affiliation: | Pediatric Infectious Diseases, University of Colorado School of Medicine, Denver 80262. |
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| Abstract: | Penciclovir (PCV) and acyclovir are acyclic guanine analogs which inhibit herpes simplex virus (HSV) DNA polymerase. Their 50% infective doses were 0.5 to 0.8 microgram/ml for clinical isolates of HSV-1 and 1.3 to 2.2 micrograms/ml for HSV-2. Furthermore, HSV-infected cultures receiving 2-h pulses of PCV had 2- to 50-fold less HSV than acyclovir-treated cultures, consistent with the prolonged intracellular half-life of PCV triphosphate. |
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