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Prednisolone clearance: a possible determinant for glucocorticoid efficacy in patients with oral vesiculo-erosive diseases |
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| Authors: | F Lozada F J Frey L Z Benet |
| Abstract: | The pharmacokinetics of prednisolone were determined in 12 patients with oral vesiculo-erosive diseases. The bioavailability of prednisone in these patients exhibited a low intersubject variability, while the metabolic clearance rate of total and of unbound prednisolone varied considerably from patient to patient. |
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