血小板衍生生长因子及其受体与肿瘤细胞的辐射抗性

在多种恶性肿瘤中,存在血小板衍生生长因子(PDGF)及其受体(PDGFR)自分泌生长刺激的异常合成。PDGF是有效的有丝分裂原和化学驱动剂,PDGFR属于酪氨酸激酶受体,当PDGFR与PDGF结合后,活化-系列下游信号通路,并产生众多的生物学效应。研究表明,PDGF和PDGFR的信号通路与肿瘤细胞辐射抗性密切相关,其机制可能与促进细胞增殖、抑制凋亡、调控细胞周期阻滞有关。

Platelet derived growth factor and its receptor and the radiation resistance of tumor cells

Platelet derived growth factor(PDGF)and platelet derived growth factor receptor(PDGFR) are abnormally synthesized following the autocrine growth activation in a number of malignant tumors.PDGF is a effective mitogen and chemical agent,PDGFR belongs to tymsine kinase receptors.After binding with corresponding ligand,PDGFR is activated and lead to activate a series of downstream signal pathways and has resulted in many biological effects.PDGF and PDGFR signal pathway is associated with radiation resistance of tumor cells,and the mechanism is likely to be related to cell proliferation,suppressing apoptosis,and regulating cell cycle arrest.